Expression of an Activation Antigen, Mo3e, Associated With the Cellular Response to Migration Inhibitory Factor by HL‐60 Promyelocytes Undergoing Monocyte‐Macrophage Differentiation
dc.contributor.author | Todd, Robert F. | |
dc.contributor.author | Bury, Martin J. | |
dc.contributor.author | Liu, David Y. | |
dc.date.accessioned | 2018-02-05T16:38:25Z | |
dc.date.available | 2018-02-05T16:38:25Z | |
dc.date.issued | 1987-06 | |
dc.identifier.citation | Todd, Robert F.; Bury, Martin J.; Liu, David Y. (1987). "Expression of an Activation Antigen, Mo3e, Associated With the Cellular Response to Migration Inhibitory Factor by HL‐60 Promyelocytes Undergoing Monocyte‐Macrophage Differentiation." Journal of Leukocyte Biology 41(6): 492-499. | |
dc.identifier.issn | 0741-5400 | |
dc.identifier.issn | 1938-3673 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/141671 | |
dc.description.abstract | HL‐60 promyelocytic cells acquire the surface expression of the Mo3e antigenic determinant after exposure to PMA or compounds that raise intracellular concentrations of cyclic AMP (dibutyryl cyclic AMP or a combination of cholera toxin and IBMX). The expression of Mo3e by these stimulated HL‐60 cells coincides with the development of features of monocyte‐macrophage differentiation (characteristic morphology, nonspecific esterase activity, and respiratory burst activity). During in vitro monocyte‐macrophage differentiation, HL‐60 cells become responsive to migration inhibitory factor (MIF); the MIF responsiveness of differentiated HL‐60 cells is blocked by anti‐Mo3e monoclonal antibody. These findings further support the relationship between the expression of Mo3e and the cellular response to MIF. | |
dc.publisher | Wiley Periodicals, Inc. | |
dc.subject.other | surface antigen expression | |
dc.subject.other | HL‐60 | |
dc.subject.other | macrophage differentiation | |
dc.subject.other | migration inhibitory factor | |
dc.title | Expression of an Activation Antigen, Mo3e, Associated With the Cellular Response to Migration Inhibitory Factor by HL‐60 Promyelocytes Undergoing Monocyte‐Macrophage Differentiation | |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Microbiology and Immunology | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.contributor.affiliationum | Simpson Memorial Research Institute, Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor (R.F.T., M.J.B.) | |
dc.contributor.affiliationother | Department of Rheumatology and Immunology, Brigham and Women’s Hospital and the Department of Medicine, Harvard Medical School, Boston (D.Y.L.) | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/141671/1/jlb0492.pdf | |
dc.identifier.doi | 10.1002/jlb.41.6.492 | |
dc.identifier.source | Journal of Leukocyte Biology | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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