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Healing of two‐wall intra‐bony defects treated with a novel EMD‐liquid—A pre‐clinical study in monkeys
dc.contributor.authorShirakata, Yoshinori
dc.contributor.authorMiron, Richard J.
dc.contributor.authorShinohara, Yukiya
dc.contributor.authorNakamura, Toshiaki
dc.contributor.authorSena, Kotaro
dc.contributor.authorHorai, Naoto
dc.contributor.authorBosshardt, Dieter D.
dc.contributor.authorNoguchi, Kazuyuki
dc.contributor.authorSculean, Anton
dc.date.accessioned2018-02-05T16:40:29Z
dc.date.available2019-01-07T18:34:38Zen
dc.date.issued2017-12
dc.identifier.citationShirakata, Yoshinori; Miron, Richard J.; Shinohara, Yukiya; Nakamura, Toshiaki; Sena, Kotaro; Horai, Naoto; Bosshardt, Dieter D.; Noguchi, Kazuyuki; Sculean, Anton (2017). "Healing of two‐wall intra‐bony defects treated with a novel EMD‐liquid—A pre‐clinical study in monkeys." Journal of Clinical Periodontology 44(12): 1264-1273.
dc.identifier.issn0303-6979
dc.identifier.issn1600-051X
dc.identifier.urihttps://hdl.handle.net/2027.42/141785
dc.description.abstractAimTo investigate the effect of a novel enamel matrix derivative formulation (EMD‐liquid or Osteogain) combined with an absorbable collagen sponge (ACS) on periodontal wound healing in intra‐bony defects in monkeys.Materials and MethodsChronic two‐wall intra‐bony defects were created at the distal aspect of eight teeth in three monkeys (Macaca fascicularis). The 24 defects were randomly assigned to one of the following treatments: (i) open flap debridement (OFD) + ACS alone, (ii) OFD + Emdogain + ACS (Emdogain/ACS), (iii) OFD + Osteogain + ACS (Osteogain/ACS) or (iv) OFD alone. At 4 months, the animals were euthanized for histologic evaluation.ResultsOsteogain/ACS resulted in more consistent formation of cementum, periodontal ligament and bone with limited epithelial proliferation compared to OFD alone, Emdogain/ACS and OFD + ACS. Among the four treatment groups, the Osteogain/ACS group demonstrated the highest amount of regenerated tissues. However, complete periodontal regeneration was not observed in any of the defects in the four groups.ConclusionsThe present findings indicate that in two‐wall intra‐bony defects, reconstructive surgery with Osteogain/ACS appears to be a promising novel approach for facilitating periodontal wound healing/regeneration, thus warranting further clinical testing.
dc.publisherWiley Periodicals, Inc.
dc.subject.otheranimal study
dc.subject.otherenamel matrix proteins
dc.subject.otherintra‐bony defect
dc.subject.otherperiodontal regeneration
dc.subject.othercarrier
dc.titleHealing of two‐wall intra‐bony defects treated with a novel EMD‐liquid—A pre‐clinical study in monkeys
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDentistry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/141785/1/jcpe12825.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/141785/2/jcpe12825_am.pdf
dc.identifier.doi10.1111/jcpe.12825
dc.identifier.sourceJournal of Clinical Periodontology
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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