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17αâ estradiol acts through hypothalamic proâ opiomelanocortin expressing neurons to reduce feeding behavior

dc.contributor.authorSteyn, Frederik J.
dc.contributor.authorNgo, Shyuan T.
dc.contributor.authorChen, Vicky Ping
dc.contributor.authorBailey‐downs, Lora C.
dc.contributor.authorXie, Teresa Y.
dc.contributor.authorGhadami, Martin
dc.contributor.authorBrimijoin, Stephen
dc.contributor.authorFreeman, Willard M.
dc.contributor.authorRubinstein, Marcelo
dc.contributor.authorLow, Malcolm J.
dc.contributor.authorStout, Michael B.
dc.date.accessioned2018-02-05T16:45:47Z
dc.date.available2019-04-01T15:01:10Zen
dc.date.issued2018-02
dc.identifier.citationSteyn, Frederik J.; Ngo, Shyuan T.; Chen, Vicky Ping; Bailey‐downs, Lora C. ; Xie, Teresa Y.; Ghadami, Martin; Brimijoin, Stephen; Freeman, Willard M.; Rubinstein, Marcelo; Low, Malcolm J.; Stout, Michael B. (2018). "17αâ estradiol acts through hypothalamic proâ opiomelanocortin expressing neurons to reduce feeding behavior." Aging Cell (1): n/a-n/a.
dc.identifier.issn1474-9718
dc.identifier.issn1474-9726
dc.identifier.urihttps://hdl.handle.net/2027.42/142068
dc.publisherWiley Periodicals, Inc.
dc.subject.other17뱉 estradiol
dc.subject.otheraging
dc.subject.otherproâ opiomelanocortin
dc.subject.otherhypothalamus
dc.subject.otherfood intake
dc.subject.otherobesity
dc.title17αâ estradiol acts through hypothalamic proâ opiomelanocortin expressing neurons to reduce feeding behavior
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/142068/1/acel12703.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/142068/2/acel12703_am.pdf
dc.identifier.doi10.1111/acel.12703
dc.identifier.sourceAging Cell
dc.identifier.citedreferenceButera, P. C., Beikirch, R. J., & Willard, D. M. ( 1990 ). Changes in ingestive behaviors and body weight following intracranial application of 17 alphaâ estradiol. Physiology & Behavior, 47, 1291 â 1293.
dc.identifier.citedreferenceBenoit, S. C., Air, E. L., Coolen, L. M., Strauss, R., Jackman, A., Clegg, D. J., â ¦ Woods, S. C. ( 2002 ). The catabolic action of insulin in the brain is mediated by melanocortins. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 22, 9048 â 9052.
dc.identifier.citedreferencede Souza, F. S., Santangelo, A. M., Bumaschny, V., Avale, M. E., Smart, J. L., Low, M. J., & Rubinstein, M. ( 2005 ). Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting. Molecular and Cellular Biology, 25, 3076 â 3086.
dc.identifier.citedreferenceCowley, M. A., Smart, J. L., Rubinstein, M., Cerdan, M. G., Diano, S., Horvath, T. L., â ¦ Low, M. J. ( 2001 ). Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature, 411, 480 â 484.
dc.identifier.citedreferenceChhabra, K. H., Adams, J. M., Fagel, B., Lam, D. D., Qi, N., Rubinstein, M., & Low, M. J. ( 2016 ). Hypothalamic POMC deficiency improves glucose tolerance despite insulin resistance by increasing glycosuria. Diabetes, 65, 660 â 672.
dc.identifier.citedreferenceBumaschny, V. F., Yamashita, M., Casasâ Cordero, R., Oteroâ Corchon, V., de Souza, F. S., Rubinstein, M., & Low, M. J. ( 2012 ). Obesityâ programmed mice are rescued by early genetic intervention. The Journal of Clinical Investigation, 122, 4203 â 4212.
dc.identifier.citedreferenceZhan, C., Zhou, J., Feng, Q., Zhang, J. E., Lin, S., Bao, J., â ¦ Luo, M. ( 2013 ). Acute and longâ term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 33, 3624 â 3632.
dc.identifier.citedreferenceWaters, D. L., Ward, A. L., & Villareal, D. T. ( 2013 ). Weight loss in obese adults 65 years and older: a review of the controversy. Experimental Gerontology, 48, 1054 â 1061.
dc.identifier.citedreferenceStrong, R., Miller, R. A., Antebi, A., Astle, C. M., Bogue, M., Denzel, M. S., â ¦ Harrison, D. E. ( 2016 ). Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an alphaâ glucosidase inhibitor or a Nrf2â inducer. Aging Cell, 15, 872 â 884.
dc.identifier.citedreferenceStout, M. B., Steyn, F. J., Jurczak, M. J., Camporez, J. G., Zhu, Y., Hawse, J. R., â ¦ Kirkland, J. L. ( 2017 ). 17alphaâ estradiol alleviates ageâ related metabolic and inflammatory dysfunction in male mice without inducing feminization. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 72, 3 â 15.
dc.identifier.citedreferenceLam, D. D., de Souza, F. S., Nasif, S., Yamashita, M., Lopezâ Leal, R., Oteroâ Corchon, V., â ¦ Low, M. J. ( 2015 ). Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold. PLoS Genetics, 11, e1004935.
dc.identifier.citedreferenceHarrison, D. E., Strong, R., Allison, D. B., Ames, B. N., Astle, C. M., Atamna, H., â ¦ Miller, R. A. ( 2014 ). Acarbose, 17â alphaâ estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell, 13, 273 â 282.
dc.identifier.citedreferenceFranchini, L. F., Lopezâ Leal, R., Nasif, S., Beati, P., Gelman, D. M., Low, M. J., â ¦ Rubinstein, M. ( 2011 ). Convergent evolution of two mammalian neuronal enhancers by sequential exaptation of unrelated retroposons. Proceedings of the National Academy of Sciences of the United States of America, 108, 15270 â 15275.
dc.identifier.citedreferenceDirks, A. J., & Leeuwenburgh, C. ( 2006 ). Caloric restriction in humans: potential pitfalls and health concerns. Mechanisms of Ageing and Development, 127, 1 â 7.
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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