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CD71+ erythroid cells from neonates born to women with preterm labor regulate cytokine and cellular responses
dc.contributor.authorMiller, Derek
dc.contributor.authorRomero, Roberto
dc.contributor.authorUnkel, Ronald
dc.contributor.authorXu, Yi
dc.contributor.authorVadillo‐ortega, Felipe
dc.contributor.authorHassan, Sonia S.
dc.contributor.authorGomez‐lopez, Nardhy
dc.date.accessioned2018-04-04T18:54:11Z
dc.date.available2019-05-13T14:45:27Zen
dc.date.issued2018-04
dc.identifier.citationMiller, Derek; Romero, Roberto; Unkel, Ronald; Xu, Yi; Vadillo‐ortega, Felipe ; Hassan, Sonia S.; Gomez‐lopez, Nardhy (2018). "CD71+ erythroid cells from neonates born to women with preterm labor regulate cytokine and cellular responses." Journal of Leukocyte Biology 103(4): 761-775.
dc.identifier.issn0741-5400
dc.identifier.issn1938-3673
dc.identifier.urihttps://hdl.handle.net/2027.42/142950
dc.description.abstractNeonatal CD71+ erythroid cells are thought to have immunosuppressive functions. Recently, we demonstrated that CD71+ erythroid cells from neonates born to women who underwent spontaneous preterm labor (PTL) are reduced to levels similar to those of term neonates; yet, their functional properties are unknown. Herein, we investigated the functionality of CD71+ erythroid cells from neonates born to women who underwent spontaneous preterm or term labor. CD71+ erythroid cells from neonates born to women who underwent PTL displayed a similar mRNA profile to that of those from term neonates. The direct contact between preterm or term neonatal CD71+ erythroid cells and maternal mononuclear immune cells, but not soluble products from these cells, induced the release of proinflammatory cytokines and a reduction in the release of TGFâ β. Moreover, PTLâ derived neonatal CD71+ erythroid cells (1) modestly altered CD8+ T cell activation; (2) inhibited conventional CD4+ and CD8+ Tâ cell expansion; (3) suppressed the expansion of CD8+ regulatory T cells; (4) regulated cytokine responses mounted by myeloid cells in the presence of a microbial product; and (5) indirectly modulated Tâ cell cytokine responses. In conclusion, neonatal CD71+ erythroid cells regulate neonatal Tâ cell and myeloid responses and their direct contact with maternal mononuclear cells induces a proinflammatory response. These findings provide insight into the biology of neonatal CD71+ erythroid cells during the physiologic and pathologic processes of labor.
dc.publisherWiley Periodicals, Inc.
dc.subject.othercytokines
dc.subject.otherpremature
dc.subject.otherregulatory T cells
dc.subject.otherT cells
dc.subject.otherumbilical cord blood
dc.subject.otherhuman
dc.subject.otherpregnancy
dc.subject.otherparturition
dc.subject.otherneonatal immunity
dc.subject.othermyeloid cells
dc.titleCD71+ erythroid cells from neonates born to women with preterm labor regulate cytokine and cellular responses
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMicrobiology and Immunology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/142950/1/jlb10051_am.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/142950/2/jlb10051-sup-0003-TableS2.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/142950/3/jlb10051-sup-0002-TableS1.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/142950/4/jlb10051-sup-0001-Figures.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/142950/5/jlb10051.pdf
dc.identifier.doi10.1002/JLB.5A0717-291RRR
dc.identifier.sourceJournal of Leukocyte Biology
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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