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Deoxyribonucleoside Phosphoramidites
dc.contributor.authorWilk, Andrzej
dc.contributor.authorGrajkowski, Andrzej
dc.contributor.authorChmielewski, Marcin K.
dc.contributor.authorBeaucage, Serge L.
dc.contributor.authorPhillips, Lawrence R.
dc.date.accessioned2018-05-15T20:12:58Z
dc.date.available2018-05-15T20:12:58Z
dc.date.issued2001-04
dc.identifier.citationWilk, Andrzej; Grajkowski, Andrzej; Chmielewski, Marcin K.; Beaucage, Serge L.; Phillips, Lawrence R. (2001). "Deoxyribonucleoside Phosphoramidites." Current Protocols in Nucleic Acid Chemistry 4(1): 2.7.1-2.7.12.
dc.identifier.issn1934-9270
dc.identifier.issn1934-9289
dc.identifier.urihttps://hdl.handle.net/2027.42/143622
dc.description.abstractThe detailed preparation of deoxyribonucleoside phosphoramidites bearing a 4‐[N‐methyl‐N‐(2,2,2‐trifluoroacetyl)amino]butyl group for P(III) protection is presented. The use of this group circumvents nucleobase alkylation during oligonucleotide deprotection. Two syntheses of phosphoramidites starting from either a phosphordichloridite precursor or a bis‐(N,N‐diisopropylamino)chlorophosphine intermediate are described for the phosphinylation of suitably protected deoxyribonucleosides.
dc.publisherHumana Press
dc.publisherWiley Periodicals, Inc.
dc.titleDeoxyribonucleoside Phosphoramidites
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelPublic Health
dc.subject.hlbsecondlevelBiological Chemistry
dc.subject.hlbsecondlevelChemical Engineering
dc.subject.hlbsecondlevelChemistry
dc.subject.hlbtoplevelHealth Sciences
dc.subject.hlbtoplevelScience
dc.subject.hlbtoplevelEngineering
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/143622/1/cpnc0207.pdf
dc.identifier.doi10.1002/0471142700.nc0207s04
dc.identifier.sourceCurrent Protocols in Nucleic Acid Chemistry
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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