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Theoretical Principles of In Vitro Selection Using Combinatorial Nucleic Acid Libraries
dc.contributor.authorVant‐hull, Barry
dc.contributor.authorGold, Larry
dc.contributor.authorZichi, Dominic A.
dc.date.accessioned2018-05-15T20:13:11Z
dc.date.available2018-05-15T20:13:11Z
dc.date.issued2000-02
dc.identifier.citationVant‐hull, Barry ; Gold, Larry; Zichi, Dominic A. (2000). "Theoretical Principles of In Vitro Selection Using Combinatorial Nucleic Acid Libraries." Current Protocols in Nucleic Acid Chemistry 00(1): 9.1.1-9.1.16.
dc.identifier.issn1934-9270
dc.identifier.issn1934-9289
dc.identifier.urihttps://hdl.handle.net/2027.42/143632
dc.description.abstractA new paradigm for drug discovery and biological research has developed from technologies that integrate combinatorial chemistry with rounds of selection and amplification, a technique called in vitro selection or systematic evolution of ligands by exponential enrichment (SELEX). This overview unit discusses nucleic acid libraries that can be used, affinity probability distributions, an equilibrium model for SELEX, and optimal conditions including concentrations and signalâ toâ noise ratios.
dc.publisherWiley Periodicals, Inc.
dc.titleTheoretical Principles of In Vitro Selection Using Combinatorial Nucleic Acid Libraries
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelPublic Health
dc.subject.hlbsecondlevelBiological Chemistry
dc.subject.hlbsecondlevelChemical Engineering
dc.subject.hlbsecondlevelChemistry
dc.subject.hlbtoplevelHealth Sciences
dc.subject.hlbtoplevelScience
dc.subject.hlbtoplevelEngineering
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/143632/1/cpnc0901.pdf
dc.identifier.doi10.1002/0471142700.nc0901s00
dc.identifier.sourceCurrent Protocols in Nucleic Acid Chemistry
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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