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Nucleobase Protection of Deoxyribo‐ and Ribonucleosides
dc.contributor.authorIyer, Radhakrishnan P.
dc.date.accessioned2018-05-15T20:14:42Z
dc.date.available2018-05-15T20:14:42Z
dc.date.issued2000-02
dc.identifier.citationIyer, Radhakrishnan P. (2000). "Nucleobase Protection of Deoxyribo‐ and Ribonucleosides." Current Protocols in Nucleic Acid Chemistry 00(1): 2.1.1-2.1.17.
dc.identifier.issn1934-9270
dc.identifier.issn1934-9289
dc.identifier.urihttps://hdl.handle.net/2027.42/143711
dc.description.abstractProtecting groups for the imide/lactam function of thymine/uracil and guanine, respectively, prevent irreversible nucleobase modifications that may occur in the presence of alkylating or condensing reagents that are commonly used in nucleoside protection and oligonucleotide synthesis. This unit reviews these protecting groups, and also identifies protecting groups for the exocyclic amino function of cytosine, adenine, and guanine. The unit also explores recent trends in nucleobase protection that permit reliable oligonucleotide synthesis and removal of N‐protecting groups under very mild conditions.
dc.publisherWiley Periodicals, Inc.
dc.publisherCRC Press
dc.titleNucleobase Protection of Deoxyribo‐ and Ribonucleosides
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelChemical Engineering
dc.subject.hlbsecondlevelChemistry
dc.subject.hlbsecondlevelPublic Health
dc.subject.hlbsecondlevelBiological Chemistry
dc.subject.hlbtoplevelHealth Sciences
dc.subject.hlbtoplevelScience
dc.subject.hlbtoplevelEngineering
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/143711/1/cpnc0201.pdf
dc.identifier.doi10.1002/0471142700.nc0201s00
dc.identifier.sourceCurrent Protocols in Nucleic Acid Chemistry
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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