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Palladium‐Mediated C5 Substitution of Pyrimidine Nucleosides
dc.contributor.authorAhmadian, Mohammad
dc.contributor.authorKlewer, Douglas A.
dc.contributor.authorBergstrom, Donald E.
dc.date.accessioned2018-05-15T20:15:02Z
dc.date.available2018-05-15T20:15:02Z
dc.date.issued2000-02
dc.identifier.citationAhmadian, Mohammad; Klewer, Douglas A.; Bergstrom, Donald E. (2000). "Palladium‐Mediated C5 Substitution of Pyrimidine Nucleosides." Current Protocols in Nucleic Acid Chemistry 00(1): 1.1.1-1.1.18.
dc.identifier.issn1934-9270
dc.identifier.issn1934-9289
dc.identifier.urihttps://hdl.handle.net/2027.42/143730
dc.description.abstractOne of the most efficient ways to link a reporter group to oligonucleotides is through the incorporation of a modified nucleoside during automated oligonucleotide synthesis. To be useful, it is important that the reporter group not interfere in hybridization reactions. This unit describes two linkers that can be used for the incorporation of a reporter group at the C5 position of deoxyuridine: a flexible aminoethylthioether linker, and a rigid amidopropynyl linker. The latter is suffciently long and positioned so that the reporter group lies outside the major groove of the DNA duplex.
dc.publisherWiley Periodicals, Inc.
dc.publisherIRL Press
dc.titlePalladium‐Mediated C5 Substitution of Pyrimidine Nucleosides
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelChemistry
dc.subject.hlbsecondlevelPublic Health
dc.subject.hlbsecondlevelBiological Chemistry
dc.subject.hlbsecondlevelChemical Engineering
dc.subject.hlbtoplevelHealth Sciences
dc.subject.hlbtoplevelScience
dc.subject.hlbtoplevelEngineering
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/143730/1/cpnc0101.pdf
dc.identifier.doi10.1002/0471142700.nc0101s00
dc.identifier.sourceCurrent Protocols in Nucleic Acid Chemistry
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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