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Synthesis of N2‐Substituted Deoxyguanosine Nucleosides from 2‐Fluoro‐6‐O‐(Trimethylsilylethyl)‐2′‐Deoxyinosine
dc.contributor.authorHarris, Thomas M.
dc.contributor.authorHarris, Constance M.
dc.date.accessioned2018-05-15T20:16:00Z
dc.date.available2018-05-15T20:16:00Z
dc.date.issued2000-02
dc.identifier.citationHarris, Thomas M.; Harris, Constance M. (2000). "Synthesis of N2‐Substituted Deoxyguanosine Nucleosides from 2‐Fluoro‐6‐O‐(Trimethylsilylethyl)‐2′‐Deoxyinosine." Current Protocols in Nucleic Acid Chemistry 00(1): 1.3.1-1.3.19.
dc.identifier.issn1934-9270
dc.identifier.issn1934-9289
dc.identifier.urihttps://hdl.handle.net/2027.42/143782
dc.description.abstractSyntheses of N2‐substituted nucleosides have been studied for many years, primarily with ribonucleosides. However, the primary route to these compounds requires acidic conditions that are too vigorous for the acid‐labile deoxyribonucleosides. The current strategy takes advantage of methods for low‐temperature, nonaqueous diazotization of ribosides in organic solvents using t‐butyl nitrate as the diazotizing agent and HF/pyridine as the fluoride source for the preaparation of a 2‐fluoro‐2?‐deoxyinosine derivative that can be used to synthesize N2‐substituted deoxyguanosine.
dc.publisherWiley Periodicals, Inc.
dc.publisherAldrich Chemical Co.
dc.titleSynthesis of N2‐Substituted Deoxyguanosine Nucleosides from 2‐Fluoro‐6‐O‐(Trimethylsilylethyl)‐2′‐Deoxyinosine
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiological Chemistry
dc.subject.hlbsecondlevelChemical Engineering
dc.subject.hlbsecondlevelChemistry
dc.subject.hlbsecondlevelPublic Health
dc.subject.hlbtoplevelEngineering
dc.subject.hlbtoplevelHealth Sciences
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/143782/1/cpnc0103.pdf
dc.identifier.doi10.1002/0471142700.nc0103s00
dc.identifier.sourceCurrent Protocols in Nucleic Acid Chemistry
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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