Show simple item record

Optical Quartz Crystal Microbalance (OQCM) for Dual-Mode Analysis

dc.contributor.authorZhang, Zhizheng
dc.date.accessioned2018-06-07T17:45:52Z
dc.date.availableNO_RESTRICTION
dc.date.available2018-06-07T17:45:52Z
dc.date.issued2018
dc.date.submitted2018
dc.identifier.urihttps://hdl.handle.net/2027.42/143989
dc.description.abstractLabel-free biosensors allow for real-time measurements of the target molecule, providing valuable kinetic data about the unperturbed biological system. Yet, they generally rely on a single transduction mechanism that reflects a single aspect of a system. In order to have a more complete understanding of the system, many aspects of the system need to be examined simultaneously. An integrated multi-mode label-free sensor capable of providing consistent and complementary information about multiple aspects of a system is highly desirable for biomedical research. Currently there are some hybrid sensors utilizing the optical and quartz crystal microbalance (QCM) techniques to measure both the optical and mechanical properties of a system. However, those hybrid sensors have some shortcomings in implementation and performance that limit their applicability. In this research, we developed Optical Quartz Crystal Microbalance (OQCM) sensors - hybrid sensors utilizing the same techniques for simultaneously measuring both optical and mechanical properties, which also address these shortcomings. Two OQCM structures were designed, fabricated and explored. The first structure is an interferometric OQCM sensor (I-OQCM) with a multilayer planar optical structure. The interference between reflections at the interfaces between layers generates an interference pattern in the optical spectrum that shifts upon accumulation of additional films on the structure. The second structure is a plasmonically-enhanced grating OQCM sensor (PEG-OQCM). The theory and simulation analyses indicate that the PEG-OQCM can achieve near zero bulk refractive index sensitivity by optimizing the incidence angle. Simulation results show that at an incident angle of 47 degrees, the bulk RI sensitivity becomes near zero around bulk RI = 1.33. Experimental results for vapor deposition, water and biosensing (solution of streptavidin) match well with the simulation results. With this PEG-OQCM structure, an optical linewidth of 25 nm was obtained in air, 15 nm in water – up to 6 times narrower than that of SPR/LSPR (50-100 nm in water). The OQCMs were characterized separately to demonstrate the operation in each mode for each structure, and tests were performed to show biosensing capability. Dual-mode tests were conducted for both the I-OQCM and PEG-OQCM to show the capability of simultaneous measurement of both optical and mechanical properties and responses of a system. The test results validate the simulation analyses and correlation between the optical and mechanical responses that would provide corroborating information for more reliable, robust cross-examination/confirmation for the evaluation of test systems. The OQCM-A sensor with 3 single I-OQCM sensors on a single wafer was also designed, fabricated. Each I-OQCM sensor can be characterized independently of the others. Mechanical response tests performed on the OQCM-A indicate that each sensor responds independently of the other sensors and the cross-talk between on adjacent sensors is negligible.
dc.language.isoen_US
dc.subjectOptical
dc.subjectOptical Quartz Crystal Microbalance
dc.subjectQuartz Crystal Microbalance
dc.subjectLabel-free
dc.subjectDual-Mode Sensor
dc.subjectPlasmonically Enhanced Grating
dc.titleOptical Quartz Crystal Microbalance (OQCM) for Dual-Mode Analysis
dc.typeThesisen_US
dc.description.thesisdegreenamePhDen_US
dc.description.thesisdegreedisciplineElectrical Engineering
dc.description.thesisdegreegrantorUniversity of Michigan, Horace H. Rackham School of Graduate Studies
dc.contributor.committeememberFan, Xudong
dc.contributor.committeememberSteel, Duncan G
dc.contributor.committeememberOgilvie, Jennifer
dc.contributor.committeememberGuo, L Jay
dc.contributor.committeememberWinful, Herbert Graves
dc.subject.hlbsecondlevelBiomedical Engineering
dc.subject.hlbsecondlevelElectrical Engineering
dc.subject.hlbsecondlevelEngineering (General)
dc.subject.hlbsecondlevelMechanical Engineering
dc.subject.hlbsecondlevelPhysics
dc.subject.hlbsecondlevelScience (General)
dc.subject.hlbtoplevelEngineering
dc.subject.hlbtoplevelScience
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/143989/1/zvzhang_1.pdf
dc.identifier.orcid0000-0003-4048-863X
dc.identifier.name-orcidZhang, Zhizheng; 0000-0003-4048-863Xen_US
dc.owningcollnameDissertations and Theses (Ph.D. and Master's)


Files in this item

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.