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From in vivo to in vitro: How the Guatemala STD Experiments Transformed Bodies Into Biospecimens

dc.contributor.authorSpector‐bagdady, Kayte
dc.contributor.authorLombardo, Paul A.
dc.date.accessioned2018-06-11T17:59:57Z
dc.date.available2019-08-01T19:53:23Zen
dc.date.issued2018-06
dc.identifier.citationSpector‐bagdady, Kayte ; Lombardo, Paul A. (2018). "From in vivo to in vitro: How the Guatemala STD Experiments Transformed Bodies Into Biospecimens." The Milbank Quarterly 96(2): 244-271.
dc.identifier.issn0887-378X
dc.identifier.issn1468-0009
dc.identifier.urihttps://hdl.handle.net/2027.42/144269
dc.publisherCTLR_001531
dc.publisherWiley Periodicals, Inc.
dc.subject.otherCommon Rule
dc.subject.otherTuskegee syphilis experiments
dc.subject.otherresearch ethics
dc.subject.otherGuatemala STD experiments
dc.titleFrom in vivo to in vitro: How the Guatemala STD Experiments Transformed Bodies Into Biospecimens
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelPublic Health (General)
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/144269/1/milq12318.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/144269/2/milq12318_am.pdf
dc.identifier.doi10.1111/1468-0009.12318
dc.identifier.sourceThe Milbank Quarterly
dc.identifier.citedreference45 CFR § 46.101â 102 (2009).
dc.identifier.citedreferenceObama B. The Precision Medicine Initiative. https://obamawhitehouse.archives.gov/node/333101. Accessed July 21, 2017.
dc.identifier.citedreferenceShuster E. Fifty years later: the significance of the Nuremberg Code. N Engl J Med. 1997; 337: 1436 â 1440.
dc.identifier.citedreferenceMoe K. Should the Nazi research data be cited ? Hastings Cent Rep. 1984; 14 ( 6 ): 5 â 7.
dc.identifier.citedreferenceSpectorâ Bagdady K. Public Health Service research in Guatemala: toward new scholarship. Hastings Cent Rep. 2013; 43 ( 4 ): 3.
dc.identifier.citedreferenceDepartment of Homeland Security, Department of Agriculture, Department of Energy, et al. Federal policy for the protection of human subjects: delay of the revisions to the federal policy for the protection of human subjects. Fed Regist. 2018; 83 ( 14 ): 2885 â 2894.
dc.identifier.citedreferenceAshburn LL to Thayer JD. April 3, 1957. PCSBI HSPI Archives: CTLR_0001532.
dc.identifier.citedreferenceDepartment of Homeland Security, Department of Agriculture, Department of Energy, et al. Federal policy for the protection of human subjects. Fed Regist. 2015; 80 ( 173 ): 53933 â 54061.
dc.identifier.citedreferenceDepartment of Health and Human Services. Human subjects research protections: enhancing protections for research subjects and reducing burden, delay, and ambiguity for investigators. Fed Regist. 2011; 76 ( 143 ): 44512 â 44531.
dc.identifier.citedreferenceMoore v. Regents of the University of California, 793 P.2d 479 (Cal. 1990).
dc.identifier.citedreferenceGreenberg v. Miami Children’s Hosp. Research Inst., Inc., 264 F. Supp. 2d 1064 (S.D. Fla. 2003).
dc.identifier.citedreferenceWashington University v. Catalona, 490 F.3d 667 (8th Cir. 2007).
dc.identifier.citedreferenceGrady C, Eckstein L, Berkman B, et al. Broad consent for research with biological samples: workshop conclusions. Am J Bioeth. 2015; 15 ( 9 ): 34 â 42.
dc.identifier.citedreferenceHenderson GE, Edwards TP, Cadigan RJ, et al. Stewardship practices of U.S. biobanks. Sci Trans Med. 2013; 5 ( 215 ). https://doi.org/10.1126/scitranslmed.3007362.
dc.identifier.citedreferenceAultman JM. Abuses and apologies: irresponsible conduct of human subjects research in Latin America. J Law Med Ethics. 2013; 41 ( 1 ): 353 â 368.
dc.identifier.citedreferenceNewkirk VR II. A generation of bad blood. The Atlantic. June 17, 2016. https://www.theatlantic.com/politics/archive/2016/06/tuskegee-study-medical-distrust-research/487439/. Accessed July 18, 2017.
dc.identifier.citedreferenceStatement of Janet Nicholson, PhD, Senior Advisor for Laboratory Science, Coordinating Center for Infectious Diseases, CDC, before the US House of Representatives Committee on Science and Technology, Subcommittee on Investigations and Oversight. September 9, 2008.
dc.identifier.citedreferenceSun LH, Dennis B. Smallpox vials, decades old, found in storage room at NIH campus in Bethesda. Washington Post. July 8, 2014. https://www.washingtonpost.com/national/health-science/smallpox-vials-found-in-storage-room-of-nih-campus-in-bethesda/2014/07/08/bfdc284a-06d2-11e4-8a6a-19355c7e870a_story.html?utm_term=.0acd0d8b432c. Accessed November 5, 2017.
dc.identifier.citedreferenceCDC. Next Steps: Biosafety and Biosecurity at the CDC. Washington, DC: CDC; December 16, 2014. https://www.cdc.gov/about/lab-safety/nextsteps.html. Accessed November 5, 2017.
dc.identifier.citedreferenceLombardo PA, Spectorâ Bagdady K. Request for information regarding the Tuskegee syphilis experiment and Guatemala STD experiment biospecimens. November 10, 2017 [on file with authors].
dc.identifier.citedreferenceAndoh R. RE: CDC/ATSDR Freedom of Information Act request of November 10, 2017. #18â 00155â FOIA. December 4, 2017 [on file with authors].
dc.identifier.citedreferenceSiegel B. Can evil beget good? Nazi data: a dilemma for science. Los Angeles Times. October 30, 1988. http://articles.latimes.com/1988-10-30/news/mn-958_1_nazi-data-issue. Accessed July 18, 2017.
dc.identifier.citedreferenceKor EM. Nazi experiments as viewed by a survivor of Mengele’s experiments. In: Caplan AL, ed. When Medicine Went Mad: Bioethics and the Holocaust. New York, NY: Springer Science and Business Media; 1992: 3 â 8.
dc.identifier.citedreferenceCutler J to Ashburn LL. Procurement of Unstained Sections. January 7, 1957. National Archives at Atlanta, Morrow, Georgia [hereafter cited as PCSBI HSPI Archives with Bates page numbering]: CTLR_001531.
dc.identifier.citedreferenceReverby S. â Normal exposureâ and inoculation syphilis: a PHS â Tuskegeeâ doctor in Guatemala, 1946â 1948. J Policy Hist. 2011; 23 ( 1 ): 6 â 28.
dc.identifier.citedreferenceBurch TA, Ashburn LL. Experimental therapy of onchocerciasis with suramin and hetrazan: results of a threeâ year study. Am J Trop Med Hyg. 1951; 31 ( 5 ): 617 â 623.
dc.identifier.citedreferencePresidential Commission for the Study of Bioethical Issues. â Ethically Impossibleâ : STD Research in Guatemala from 1946 to 1948. Washington, DC: Government Printing Office; 2011.
dc.identifier.citedreferenceMagnuson HJ to McGavran EG. June 25, 1951. Collection 40120, Records of the School of Public Health, 1930â 1998. University Archives at the Louis Round Wilson Special Collections Library, University of North Carolina at Chapel Hill, School of Public Health.
dc.identifier.citedreferencePresidential Commission for the Study of Bioethical Issues. Guatemala Subject Data Spreadsheet. https://bioethicsarchive.georgetown.edu/pcsbi/node/650.html. Published February 17, 2012. Accessed July 21, 2017.
dc.identifier.citedreferenceCutler JC to Thayer JD. Autopsy and Biopsy Material from Patients with Syphilis and Gonorrhea. November 15, 1956. PCSBI HSPI Archives: CTLR_0001533.
dc.identifier.citedreferenceCenters for Disease Control and Prevention. Report on Findings from the U.S. Public Health Service Sexually Transmitted Disease Inoculation Study of 1946â 1948, Based on Review of Archived Papers of John Cutler, MD, at the University of Pittsburgh. Washington, DC: Department of Health and Human Services; 2010.
dc.identifier.citedreferenceLa Comisión Presidencial para el Esclarecimiento de los Experimentos Practicados con Humanos en Guatemala. Consentir el Daño: Experimentos Médicos de Estados Unidos en Guatemala, 1946â 1948. Guatemala City, Guatemala: Government of Guatemala; 2011. https://www.cityprojectca.org/blog/wp-content/uploads/2012/07/Guatemala-Report-Consentir-Spanish-201110.pdf. Accessed July 21, 2017.
dc.identifier.citedreferenceLa Comisión Presidencial para el Esclarecimiento de los Experimentos Practicados con Humanos en Guatemala: Comisión Técnica. Experimentos en Seres Humanos: El Caso Guatemala, 1946â 1948. Guatemala City, Guatemala: Government of Guatemala; 2011. https://www.cityprojectca.org/blog/wp-content/uploads/2012/07/technical-report-Spanish-201104.pdf. Accessed July 21, 2017.
dc.identifier.citedreferenceArchivo Histórico de la Policía Nacional, Archivo General de Centro América, y la Dirección de los Archivos de la Paz. Investigación Archivística Sobre Experimentos Practicados en Seres Humanos en Guatemala, 1947â 1948. Guatemala City, Guatemala: Government of Guatemala; 2011. https://www.cityprojectca.org/blog/wp-content/uploads/2012/07/archival-report-Spanish-13052011.pdf. Accessed July 21, 2017.
dc.identifier.citedreferenceSpectorâ Bagdady K, Lombardo PA. â Something of an adventureâ : postwar NIH research ethos and the Guatemala STD experiments. J Law Med Ethics. 2013; 41 ( 3 ): 697 â 710.
dc.identifier.citedreferenceGalarneau C. â Ever vigilantâ in â Ethically Impossible â : structural injustice and responsibility in PHS research in Guatemala. Hastings Cent Rep. 2013; 43 ( 3 ): 36 â 45.
dc.identifier.citedreferenceFrieden TR, Collins FS. Intentional infection of vulnerable populations in 1946â 1948: another tragic history lesson. JAMA. 2010; 304 ( 18 ): 2063 â 2064.
dc.identifier.citedreferenceCohen IG, Lynch HF. Guatemalans used in experiments deserve compensation. New York Times. July 4, 2012. http://mobile.nytimes.com/2012/07/05/opinion/guatemalans-used-in-experiments-deserve-compensation.html. Accessed May 12, 2016.
dc.identifier.citedreferenceLombardo PA. When heroes stumble. Sex Transm Dis. 2013; 40 ( 12 ): 280.
dc.identifier.citedreferenceVenereal Disease Research Laboratory. Report on Serologic Followâ up on Patients Done at CDC in 1953, Samples Sent from Guatemala. 1953. PCSBI HSPI Archives: CTLR_0001433â 76.
dc.identifier.citedreferenceDepartment of Homeland Security, Department of Agriculture, Department of Energy, et al. Federal policy for the protection of human subjects. Final rule. Fed Regist. 2017; 82 ( 12 ): 7149 â 7274.
dc.identifier.citedreferenceJones JH. Bad Blood. New York, NY: Free Press; 1993.
dc.identifier.citedreferenceSmith JD, Birkeland AC, Goldman EB, et al. The immortal life of the Common Rule: ethics, consent, and the future of cancer research. J Clin Oncol. 2017; 35 ( 17 ): 1879 â 1883.
dc.identifier.citedreferenceMoore JE to Van Slyke CJ. May 26, 1947. PCSBI HSPI Archives: NARAâ II_0000036.
dc.identifier.citedreferenceNational Archives and Records Administration. Records of Dr. John C. Cutler. Prison and Insane Asylum Photographs to Accompany Final Report. Photos 1:71. https://www.archives.gov/research/health/cdc-cutler-records. Published March 28, 2011. Accessed July 24, 2017.
dc.identifier.citedreferenceStout GW, Cutler JC. Serology problems (syphilis) in Central America. J Vener Dis Inf. 1951; 32 ( 9 ): 237 â 241.
dc.identifier.citedreferenceStout G, Guzman M, Scrimshaw NS. Presumptive false positive serologic reactions for syphilis in Central America. Am J Syph Gonorrhea Vener Dis. 1952; 36 ( 1 ): 41 â 48.
dc.identifier.citedreferenceStout G, Guzman M, Scrimshaw NS. Presumptive false positive serologic reactions for syphilis in Central America. II. Relation to serum ascorbic acid, riboflavin, alkaline phosphatase, carotene, and vitamins A and E in blood serum. Am J Syph Gonorrhea Vener Dis. 1952; 36 ( 1 ): 49 â 54.
dc.identifier.citedreferenceStout G, Mendez J, Guzman M, Scrimshaw NS. Presumptive false positive serologic reactions for syphilis in Central America. III. Relation to serum protein, albumin, and globulin. Am J Syph Gonorrhea Vener Dis. 1952; 36 ( 1 ): 55 â 59.
dc.identifier.citedreferenceStout G, Aguirre F, Scrimshaw NS. Presumptive false positive serologic reactions for syphilis in Central America. IV. Relation to positive reactions for cephalin cholesterol (Hanger) flocculation test. Am J Syph Gonorrhea Vener Dis. 1952; 36 ( 1 ): 60 â 63.
dc.identifier.citedreferenceThome JV. Encuestas serológicas centroamericanas realizadas durante los años 1950, 1951, 1952, y 1953. Bol Oficina Sanit Panam. 1955; 39 ( 2 ): 131 â 145.
dc.identifier.citedreferenceCutler JC to Mahoney JF. August 26, 1948. PCSBI HSPI Archives: CTLR_0001162â 3.
dc.identifier.citedreferenceFunes JM. Special Consultant Appointment Recommendation. December 10, 1948. PCSBI HSPI Archives: NPRC_0000807.
dc.identifier.citedreferenceSubject Notecards: Box 6. December 12, 1949. PCSBI HSPI Archives: CTLR_0006098.
dc.identifier.citedreferenceMorrison CH to Andrada G. April 5, 1950. PCSBI HSPI Archives: NPRC_0001964.
dc.identifier.citedreferenceRoy B. The Tuskegee syphilis experiment: biotechnology and the administrative state. J Natl Med Assoc. 1995; 87 ( 1 ): 56 â 67.
dc.identifier.citedreferenceFletcher JC. A case study in historical relativism. In: Reverby S, ed. Tuskegee’s Truths: Rethinking the Tuskegee Syphilis Study. Chapel Hill, NC: University of North Carolina Press; 2000: 276 â 298.
dc.identifier.citedreferenceOlansky S, Harris A, Cutler JC, Price EV. Untreated syphilis in the male Negro: twentyâ two years of serologic observation in a selected syphilis study group. AMA Arch Derm. 1956; 73 ( 5 ): 516 â 522.
dc.identifier.citedreferenceAndrews JM to Division Chiefs, Bureau of State Services. Summary of Operational Research Projects for Calendar Year 1953. Summary of Projects File. RG 442â 56A172, 1/1. November 15, 1954. National Archives and Records Administration, College Park, MD: 10 â 11, 14.
dc.identifier.citedreferenceMagnuson HJ, Thomas EW, Olansky S, Kaplan BI, De Mello L, Cutler JC. Inoculation syphilis in human volunteers. Medicine (Baltimore). 1956; 35 ( 1 ): 33 â 82.
dc.identifier.citedreferenceSymposium on Antibiotics. J Pharm Sci. 1956; 45 ( 6 ): 388.
dc.identifier.citedreferenceFaculty members present technical health papers. The Daily Tar Heel. October 19, 1956.
dc.identifier.citedreferenceWeindling PJ. The Nazi medical experiments. In: Emanuel EJ, Grady CC, Crouch RA, Lie LK, Miller FG, Wendler D, eds. The Oxford Textbook of Clinical Research Ethics. New York, NY: Oxford University Press; 2011: 18 â 30.
dc.identifier.citedreferenceDickman S. Scandal over Nazi victimsâ corpses rocks universities. Nature. 1989; 337 ( 19 ): 195.
dc.identifier.citedreferencePost SG. The echo of Nuremberg: Nazi data and ethics. J Med Ethics. 1991; 17 ( 1 ): 42 â 44.
dc.identifier.citedreferenceAuschwitzâ Birkenau Memorial and Museum. Historical Collection. OÅ wiÄ cim, Poland: Auschwitzâ Birkenau State Museum; 2017. http://auschwitz.org/en/museum/historical-collection/. Accessed May 16, 2017.
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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