In ineffective esophageal motility, failed swallows are more functionally relevant than weak swallows

Abstract

BackgroundEsophageal pressure topography (EPT) diagnosis of ineffective esophageal motility (IEM) can be non‐specific with unclear clinical significance.AimsTo determine whether peristaltic vigor or lower esophageal sphincter (LES) integrity is associated with poor clearance and acid reflux in IEM.MethodsBolus clearance on high‐resolution impedance manometry (HRIM) and available reflux studies in patients with IEM were retrospectively reviewed. Bolus clearance was assessed using both line tracing and colored contour methods on HRIM. EPT parameters, bolus clearance, and acid reflux variables were explored.Key ResultsEighty‐eight patients with IEM were included. Bolus clearance occurred in 71% of all swallows, and 55.7% of patients had complete bolus transit (CBT, bolus clearance in ≥80% of swallows). Bolus clearance was impaired in swallows with distal contractile integral (DCI) <100 mmHg•cm•s compared to DCI 100‐450 (0.43 vs 0.79, P < .0001). A cutoff at DCI 100 mmHg•cm•s was associated with clearance with an accuracy of 76% compared to 49% at DCI 450 (P = .0001 for both). A median DCI <100 was associated with a higher Eckardt score (9 vs 3, P = .03), and on reflux testing available in 47 patients, with abnormal acid exposure time (P = .002). Peristaltic reserve (PR) defined as (DCI of multiple rapid swallow/median DCI of wet swallows), integrated relaxation pressure, and resting lower esophageal sphincter pressure were not associated with clearance or acid exposure.Conclusions & InferencesFailed peristalsis, as defined by DCI <100 mmHg•cm•s, is associated with impaired bolus clearance and more severe dysphagia in IEM, and likely abnormal acid exposure.Ineffective esophageal motility (IEM) is an esophageal motility disorder with unclear clinical implications. We assess bolus transit, acid exposure, and symptoms in IEM. IEM with a distal contractile integral <100 mmHg•cm•s is associated with impaired bolus clearance and a higher degree of dysphagia.