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Accommodation in ABO‐incompatible organ transplants

dc.contributor.authorGarcia de Mattos Barbosa, Mayara
dc.contributor.authorCascalho, Marilia
dc.contributor.authorPlatt, Jeffrey L.
dc.date.accessioned2018-07-13T15:46:47Z
dc.date.available2019-07-01T14:52:17Zen
dc.date.issued2018-05
dc.identifier.citationGarcia de Mattos Barbosa, Mayara; Cascalho, Marilia; Platt, Jeffrey L. (2018). "Accommodation in ABO‐incompatible organ transplants." Xenotransplantation (3): n/a-n/a.
dc.identifier.issn0908-665X
dc.identifier.issn1399-3089
dc.identifier.urihttps://hdl.handle.net/2027.42/144607
dc.description.abstractAccommodation refers to a condition in which a transplant (or any tissue) appears to resist immune‐mediated injury and loss of function. Accommodation was discovered and has been explored most thoroughly in ABO‐incompatible kidney transplantation. In this setting, kidney transplants bearing blood group A or B antigens often are found to function normally in recipients who lack and hence produce antibodies directed against the corresponding antigens. Whether accommodation is owed to changes in anti‐blood group antibodies, changes in antigen or a change in the response of the transplant to antibody binding are critically reviewed and a new working model that allows for the kinetics of development of accommodation is put forth. Regardless of how accommodation develops, observations on the fate of ABO‐incompatible transplants offer lessons applicable more broadly in transplantation and in other fields.
dc.publisherBlackwell Scientific Publications
dc.publisherWiley Periodicals, Inc.
dc.subject.otherblood type
dc.subject.otherkidney transplant
dc.subject.otherrejection
dc.subject.otherblood group
dc.subject.otheraccommodation
dc.subject.otherABO‐incompatible transplant
dc.titleAccommodation in ABO‐incompatible organ transplants
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelNatural Resources and Environment
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/144607/1/xen12418.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/144607/2/xen12418_am.pdf
dc.identifier.doi10.1111/xen.12418
dc.identifier.sourceXenotransplantation
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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