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Gas chromatography mass spectrometry assay for ketamine and its metabolites in plasma
dc.contributor.authorLau, Serrine S.
dc.contributor.authorDomino, Edward F.
dc.date.accessioned2018-07-13T15:48:23Z
dc.date.available2018-07-13T15:48:23Z
dc.date.issued1977-10
dc.identifier.citationLau, Serrine S.; Domino, Edward F. (1977). "Gas chromatography mass spectrometry assay for ketamine and its metabolites in plasma." Biomedical Mass Spectrometry 4(5): 317-321.
dc.identifier.issn0306-042X
dc.identifier.issn1096-9888
dc.identifier.urihttps://hdl.handle.net/2027.42/144691
dc.description.abstractA highly sensitive and specific method for quantitation of ketamine and two of its metabolites found in monkey, dog and human plasma was developed using a gas chromatography selected ion monitoring assay operated in both electron impact and chemical ionization modes. This technique yields excellent precision, reproducibility and accuracy. From 1 ng to 3 μg of ketamine or its metabolites in 1 ml of plasma can be detected. The technique of electron capture gas chromatography is compared. All three assays were found to be quite useful but the gas chromatography mass spectrometry techniques were more specific.
dc.publisherJohn Wiley & Sons, Ltd.
dc.titleGas chromatography mass spectrometry assay for ketamine and its metabolites in plasma
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiomedical Engineering
dc.subject.hlbtoplevelHealth Sciences
dc.subject.hlbtoplevelEngineering
dc.description.peerreviewedPeer Reviewed
dc.contributor.affiliationumDepartment of Pharmacology, The University of Michigan, Ann Arbor, Michigan 48109, U.S.A.
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/144691/1/bms1200040508.pdf
dc.identifier.doi10.1002/bms.1200040508
dc.identifier.sourceBiomedical Mass Spectrometry
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dc.identifier.citedreferenceT. Chang, A. Savory, M. Albin, R. Goulet and A. Glazko, Clin. Res. 18, 597 ( 1970 ).
dc.identifier.citedreferenceM. Cohen, S. Chan, W. Way and A. Trevor, Anesthesiology 39, 370 ( 1973 ).
dc.identifier.citedreferenceT. Chang, W. A. Dill and A. Glazko, Fed. Proc. 24, 268 ( 1965 ).
dc.identifier.citedreferenceW. A. Dill, L. Chucot, T. Chang and A. Glazko, Anesthesiology 34, 73 ( 1971 ).
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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