Biomanufacturing Technologies for Engineering Biology
dc.contributor.author | Alliance for Manufacturing Foresight, MForesight: | |
dc.date.accessioned | 2018-07-18T20:37:46Z | |
dc.date.available | 2018-07-18T20:37:46Z | |
dc.date.issued | 2016-08 | |
dc.identifier.other | MF-RR-2016-0101 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/144782 | |
dc.description.abstract | Engineering Biology seeks to apply engineering principles to design, modify, and produce customized biological components and systems. The recent advent of tools such as the CRISPR/Cas9 system for gene editing and gene regulation has sharply accelerated development in this exciting field. However, several challenges need to be addressed in order to transition laboratory-scale results to commercial-scale solutions. This report identifies emerging platform technologies that, if matured, will accelerate the growth in the rapidly changing field of Engineering Biology. The conclusions in the report are intended to guide stakeholders from government, industry and academia as they seek to further develop innovations in this field.The technologies that clearly met the selection criteria include: • The key platform technology—Standardized Verified and Tractable Host Cells or Strains for Biomanufacturing—will provide industries with host cells and strains that are amenable to engineering for scale-up or scale-out. The standardized and verified nature of these hosts will streamline regulatory processes and significantly de-risk aspects of the biomanufacturing process. • Several enabling tools are needed to fully realize the potential offered by the development of tractable host cells or strains. These tools will also enable more rapid Design-Build-Test-Learn (DBTL) cycles, which is critical for the development of new host cells or strains. These tools include: (i) High Throughput Omics; (ii) Low-Cost and Error Free DNA Elements and DNA Assembly; and (iii) Efficient, Host-Neutral Gene Editing. | en_US |
dc.description.sponsorship | National Science Foundation, Grant No. 1552534 | en_US |
dc.language.iso | en_US | en_US |
dc.subject | biomanufacturing, manufacturing, engineering biology | en_US |
dc.title | Biomanufacturing Technologies for Engineering Biology | en_US |
dc.type | Technical Report | en_US |
dc.subject.hlbsecondlevel | Mechanical Engineering | |
dc.subject.hlbtoplevel | Engineering | |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/144782/1/EngineeringBiology_Final.pdf | |
dc.description.filedescription | Description of EngineeringBiology_Final.pdf : Report | |
dc.owningcollname | MForesight |
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