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Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children

dc.contributor.authorLewis, Toby C
dc.contributor.authorMetitiri, Ediri E
dc.contributor.authorMentz, Graciela B
dc.contributor.authorRen, Xiaodan
dc.contributor.authorCarpenter, Ashley R
dc.contributor.authorGoldsmith, Adam M
dc.contributor.authorWicklund, Kyra E
dc.contributor.authorEder, Breanna N
dc.contributor.authorComstock, Adam T
dc.contributor.authorRicci, Jeannette M
dc.contributor.authorBrennan, Sean R
dc.contributor.authorWashington, Ginger L
dc.contributor.authorOwens, Kendall B
dc.contributor.authorMukherjee, Bhramar
dc.contributor.authorRobins, Thomas G
dc.contributor.authorBatterman, Stuart A
dc.contributor.authorHershenson, Marc B
dc.date.accessioned2018-11-26T10:30:06Z
dc.date.available2018-11-26T10:30:06Z
dc.date.issued2018-11-21
dc.identifier.citationRespiratory Research. 2018 Nov 21;19(1):228
dc.identifier.urihttps://doi.org/10.1186/s12931-018-0922-9
dc.identifier.urihttps://hdl.handle.net/2027.42/146519
dc.description.abstractAbstract Background Few longitudinal studies examine inflammation and lung function in asthma. We sought to determine the cytokines that reduce airflow, and the influence of respiratory viral infections on these relationships. Methods Children underwent home collections of nasal lavage during scheduled surveillance periods and self-reported respiratory illnesses. We studied 53 children for one year, analyzing 392 surveillance samples and 203 samples from 85 respiratory illnesses. Generalized estimated equations were used to evaluate associations between nasal lavage biomarkers (7 mRNAs, 10 proteins), lung function and viral infection. Results As anticipated, viral infection was associated with increased cytokines and reduced FVC and FEV1. However, we found frequent and strong interactions between biomarkers and virus on lung function. For example, in the absence of viral infection, CXCL10 mRNA, MDA5 mRNA, CXCL10, IL-4, IL-13, CCL4, CCL5, CCL20 and CCL24 were negatively associated with FVC. In contrast, during infection, the opposite relationship was frequently found, with IL-4, IL-13, CCL5, CCL20 and CCL24 levels associated with less severe reductions in both FVC and FEV1. Conclusions In asthmatic children, airflow obstruction is driven by specific pro-inflammatory cytokines. In the absence of viral infection, higher cytokine levels are associated with decreasing lung function. However, with infection, there is a reversal in this relationship, with cytokine abundance associated with reduced lung function decline. While nasal samples may not reflect lower airway responses, these data suggest that some aspects of the inflammatory response may be protective against viral infection. This study may have ramifications for the treatment of viral-induced asthma exacerbations.
dc.titleInfluence of viral infection on the relationships between airway cytokines and lung function in asthmatic children
dc.typeArticleen_US
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/146519/1/12931_2018_Article_922.pdf
dc.language.rfc3066en
dc.rights.holderThe Author(s).
dc.date.updated2018-11-26T10:30:10Z
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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