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Combinatorial lentiviral gene delivery of pro‐oligodendrogenic factors for improving myelination of regenerating axons after spinal cord injury
dc.contributor.authorSmith, Dominique R.
dc.contributor.authorMargul, Daniel J.
dc.contributor.authorDumont, Courtney M.
dc.contributor.authorCarlson, Mitchell A.
dc.contributor.authorMunsell, Mary K.
dc.contributor.authorJohnson, Mitchell
dc.contributor.authorCummings, Brian J.
dc.contributor.authorAnderson, Aileen J.
dc.contributor.authorShea, Lonnie D.
dc.date.accessioned2018-12-06T17:36:24Z
dc.date.available2020-03-03T21:29:36Zen
dc.date.issued2019-01
dc.identifier.citationSmith, Dominique R.; Margul, Daniel J.; Dumont, Courtney M.; Carlson, Mitchell A.; Munsell, Mary K.; Johnson, Mitchell; Cummings, Brian J.; Anderson, Aileen J.; Shea, Lonnie D. (2019). "Combinatorial lentiviral gene delivery of pro‐oligodendrogenic factors for improving myelination of regenerating axons after spinal cord injury." Biotechnology and Bioengineering 116(1): 155-167.
dc.identifier.issn0006-3592
dc.identifier.issn1097-0290
dc.identifier.urihttps://hdl.handle.net/2027.42/146575
dc.description.abstractSpinal cord injury (SCI) results in paralysis below the injury and strategies are being developed that support axonal regrowth, yet recovery lags, in part, because many axons are not remyelinated. Herein, we investigated strategies to increase myelination of regenerating axons by overexpression of platelet‐derived growth factor (PDGF)‐AA and noggin either alone or in combination in a mouse SCI model. Noggin and PDGF‐AA have been identified as factors that enhance recruitment and differentiation of endogenous progenitors to promote myelination. Lentivirus encoding for these factors was delivered from a multichannel bridge, which we have previously shown creates a permissive environment and supports robust axonal growth through channels. The combination of noggin+PDGF enhanced total myelination of regenerating axons relative to either factor alone, and importantly, enhanced functional recovery relative to the control condition. The increase in myelination was consistent with an increase in oligodendrocyte‐derived myelin, which was also associated with a greater density of cells of an oligodendroglial lineage relative to each factor individually and control conditions. These results suggest enhanced myelination of regenerating axons by noggin+PDGF that act on oligodendrocyte‐lineage cells post‐SCI, which ultimately led to improved functional outcomes.Spinal cord injury (SCI) results in paralysis below the injury and strategies are being developed that support axonal regrowth, yet recovery lags, in part because many axons are not remyelinated. Herein, we investigated strategies to increase myelination of regenerating axons by overexpression of platelet‐derived growth factor‐AA and noggin either alone or in combination in a mouse SCI model.
dc.publisherWiley Periodicals, Inc.
dc.subject.othertissue engineering
dc.subject.otherspinal cord injury (SCI)
dc.subject.othermyelination
dc.subject.othergene therapy
dc.titleCombinatorial lentiviral gene delivery of pro‐oligodendrogenic factors for improving myelination of regenerating axons after spinal cord injury
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelPublic Health
dc.subject.hlbsecondlevelStatistics and Numeric Data
dc.subject.hlbsecondlevelBiological Chemistry
dc.subject.hlbsecondlevelEcology and Evolutionary Biology
dc.subject.hlbsecondlevelMathematics
dc.subject.hlbsecondlevelNatural Resources and Environment
dc.subject.hlbtoplevelSocial Sciences
dc.subject.hlbtoplevelHealth Sciences
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/146575/1/bit26838_am.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/146575/2/bit26838.pdf
dc.identifier.doi10.1002/bit.26838
dc.identifier.sourceBiotechnology and Bioengineering
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