SCN5A mutation status increases the risk of major arrhythmic events in Asian populations with Brugada syndrome: systematic review and meta‐analysis
dc.contributor.author | Rattanawong, Pattara | |
dc.contributor.author | Chenbhanich, Jirat | |
dc.contributor.author | Mekraksakit, Poemlarp | |
dc.contributor.author | Vutthikraivit, Wasawat | |
dc.contributor.author | Chongsathidkiet, Pakawat | |
dc.contributor.author | Limpruttidham, Nath | |
dc.contributor.author | Prasitlumkum, Narut | |
dc.contributor.author | Chung, Eugene H. | |
dc.date.accessioned | 2019-01-15T20:25:21Z | |
dc.date.available | 2020-03-03T21:29:35Z | en |
dc.date.issued | 2019-01 | |
dc.identifier.citation | Rattanawong, Pattara; Chenbhanich, Jirat; Mekraksakit, Poemlarp; Vutthikraivit, Wasawat; Chongsathidkiet, Pakawat; Limpruttidham, Nath; Prasitlumkum, Narut; Chung, Eugene H. (2019). "SCN5A mutation status increases the risk of major arrhythmic events in Asian populations with Brugada syndrome: systematic review and meta‐analysis." Annals of Noninvasive Electrocardiology 24(1): n/a-n/a. | |
dc.identifier.issn | 1082-720X | |
dc.identifier.issn | 1542-474X | |
dc.identifier.uri | https://hdl.handle.net/2027.42/146897 | |
dc.description.abstract | BackgroundBrugada syndrome (BrS) is an inherited arrhythmic disease linked to SCN5A mutations. It is controversial whether SCN5A mutation carriers possess a greater risk of major arrhythmic events (MAE). We examined the association of SCN5A mutations and MAE in BrS patients.MethodsWe comprehensively searched the databases of MEDLINE and EMBASE from inception to September 2017. Included studies were published cohort and case–control studies that compared MAE in BrS patients with and without SCN5A mutations. Data from each study were combined using the random‐effects model. Generic inverse variance method of DerSimonian and Laird was employed to calculate the risk ratios (RR) and 95% confidence intervals (CI).ResultsSeven studies from March 2002 to October 2017 were included (1,049 BrS subjects). SCN5A mutations were associated with MAE in Asian populations (RR = 2.03, 95% CI: 1.37–3.00, p = 0.0004, I2 = 0.0%), patients who were symptomatic (RR = 2.66, 95% CI: 1.62–4.36, p = 0.0001, I2 = 23.0%), and individuals with spontaneous type‐1 Brugada pattern (RR = 1.84, 95% CI: 1.05–3.23, p = 0.03, I2 = 0.0%).ConclusionsSCN5A mutations in BrS increase the risk of MAE in Asian populations, symptomatic BrS patients, and individuals with spontaneous type‐1 Brugada pattern. Our study suggests that SCN5A mutation status should be an important tool for risk assessment in BrS patients. | |
dc.publisher | Wiley Periodicals, Inc. | |
dc.subject.other | Brugada syndrome | |
dc.subject.other | genetic | |
dc.subject.other | major arrhythmic events | |
dc.subject.other | SCN5A | |
dc.subject.other | sudden cardiac death | |
dc.title | SCN5A mutation status increases the risk of major arrhythmic events in Asian populations with Brugada syndrome: systematic review and meta‐analysis | |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/146897/1/anec12589_am.pdf | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/146897/2/anec12589.pdf | |
dc.identifier.doi | 10.1111/anec.12589 | |
dc.identifier.source | Annals of Noninvasive Electrocardiology | |
dc.identifier.citedreference | Probst, V., Wilde, A. A., Barc, J., Sacher, F., Babuty, D., Mabo, P., … Schott, J. J. ( 2009 ). SCN5A mutations and the role of genetic background in the pathophysiology of Brugada syndrome. Circulation: Cardiovascular Genetics, 2 ( 6 ), 552 – 557. https://doi.org/10.1161/CIRCGENETICS.109.853374 | |
dc.identifier.citedreference | Jeevaratnam, K., Rewbury, R., Zhang, Y., Guzadhur, L., Grace, A. A., Lei, M., & Huang, C. L. ( 2012 ). Frequency distribution analysis of activation times and regional fibrosis in murine Scn5a+/‐ hearts: The effects of ageing and sex. Mechanisms of Ageing and Development, 133 ( 9–10 ), 591 – 599. https://doi.org/10.1016/j.mad.2012.07.006 | |
dc.identifier.citedreference | Juang, J. J., & Horie, M. ( 2016 ). Genetics of Brugada syndrome. Journal of Arrhythmia, 32 ( 5 ), 418 – 425. https://doi.org/10.1016/j.joa.2016.07.012 | |
dc.identifier.citedreference | Kamakura, S. ( 2013 ). Epidemiology of Brugada syndrome in Japan and rest of the world. Journal of Arrhythmia, 29 ( 2 ), 52 – 55. https://doi.org/10.1016/j.joa.2013.01.004 | |
dc.identifier.citedreference | Mademont‐Soler, I., Pinsach‐Abuin, M. L., Riuro, H., Mates, J., Perez‐Serra, A., Coll, M., … Brugada, R. ( 2016 ). Large genomic imbalances in Brugada syndrome. PLoS One, 11 ( 9 ), e0163514. https://doi.org/10.1371/journal.pone.0163514 | |
dc.identifier.citedreference | Makarawate, P., Chaosuwannakit, N., Vannaprasaht, S., Sahasthas, D., Koo, S. H., Lee, E. J. D., … Sawanyawisuth, K. ( 2017 ). SCN5A genetic polymorphisms associated with increased defibrillator shocks in Brugada syndrome. Journal of the American Heart Association, 6 ( 6 ), 1 – 7. https://doi.org/10.1161/jaha.116.005009 | |
dc.identifier.citedreference | Meregalli, P. G., Tan, H. L., Probst, V., Koopmann, T. T., Tanck, M. W., Bhuiyan, Z. A., … Wilde, A. A. ( 2009 ). Type of SCN5A mutation determines clinical severity and degree of conduction slowing in loss‐of‐function sodium channelopathies. Heart Rhythm: the Official Journal of the Heart Rhythm Society, 6 ( 3 ), 341 – 348. https://doi.org/10.1016/j.hrthm.2008.11.009 | |
dc.identifier.citedreference | Meregalli, P. G., Wilde, A. A., & Tan, H. L. ( 2005 ). Pathophysiological mechanisms of Brugada syndrome: Depolarization disorder, repolarization disorder, or more? Cardiovascular Research, 67 ( 3 ), 367 – 378. https://doi.org/10.1016/j.cardiores.2005.03.005 | |
dc.identifier.citedreference | Nademanee, K., Raju, H., de Noronha, S. V., Papadakis, M., Robinson, L., Rothery, S., … Behr, E. R. ( 2015 ). Fibrosis, connexin‐43, and conduction abnormalities in the Brugada syndrome. Journal of the American College of Cardiology, 66 ( 18 ), 1976 – 1986. https://doi.org/10.1016/j.jacc.2015.08.862 | |
dc.identifier.citedreference | Nademanee, K., Veerakul, G., Chandanamattha, P., Chaothawee, L., Ariyachaipanich, A., Jirasirirojanakorn, K., … Ngarmukos, T. ( 2011 ). Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular outflow tract epicardium. Circulation, 123 ( 12 ), 1270 – 1279. https://doi.org/10.1161/CIRCULATIONAHA.110.972612 | |
dc.identifier.citedreference | Nishii, N., Ogawa, M., Morita, H., Nakamura, K., Banba, K., Miura, D., … Ito, H. ( 2010 ). SCN5A mutation is associated with early and frequent recurrence of ventricular fibrillation in patients with Brugada syndrome. Circulation Journal, 74 ( 12 ), 2572 – 2578. https://doi.org/10.1253/circj.CJ-10-0445 | |
dc.identifier.citedreference | Patsopoulos, N. A., Evangelou, E., & Ioannidis, J. P. ( 2008 ). Sensitivity of between‐study heterogeneity in meta‐analysis: Proposed metrics and empirical evaluation. International Journal of Epidemiology, 37 ( 5 ), 1148 – 1157. https://doi.org/10.1093/ije/dyn065 | |
dc.identifier.citedreference | Priori, S. G., Napolitano, C., Gasparini, M., Pappone, C., Della Bella, P., Giordano, U., … Nastoli, J. ( 2002 ). Natural history of Brugada syndrome: Insights for risk stratification and management. Circulation, 105 ( 11 ), 1342 – 1347. https://doi.org/10.1161/hc1102.105288 | |
dc.identifier.citedreference | Priori, S. G., Wilde, A. A., Horie, M., Cho, Y., Behr, E. R., Berul, C., … Tracy, C. ( 2013 ). HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: Document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. Heart Rhythm: the Official Journal of the Heart Rhythm Society, 10 ( 12 ), 1932 – 1963. https://doi.org/10.1016/j.hrthm.2013.05.014 | |
dc.identifier.citedreference | Probst, V., Veltmann, C., Eckardt, L., Meregalli, P. G., Gaita, F., Tan, H. L., … Wilde, A. A. ( 2010 ). Long‐term prognosis of patients diagnosed with Brugada syndrome: Results from the FINGER Brugada Syndrome Registry. Circulation, 121 ( 5 ), 635 – 643. https://doi.org/10.1161/circulationaha.109.887026 | |
dc.identifier.citedreference | Rattanawong, P., Ngarmukos, T., Chung, E. H., Vutthikraivit, W., Putthapiban, P., Sukhumthammarat, W., … Sritara, P. ( 2017 ). Prevalence of Brugada ECG pattern in Thailand from a population‐based cohort study. Journal of the American College of Cardiology, 69 ( 10 ), 1355 – 1356. https://doi.org/10.1016/j.jacc.2016.12.028 | |
dc.identifier.citedreference | Rattanawong, P., Riangwiwat, T., Prasitlumkum, N., Limpruttidham, N., Kanjanahattakij, N., Chongsathidkiet, P., … Chung, E. H. ( 2017 ). Baseline fragmented QRS increases the risk of major arrhythmic events in Brugada syndrome: Systematic review and meta‐analysis. Annals of Noninvasive Electrocardiology, 23 ( 2 ), e12507. https://doi.org/10.1111/anec.12507 | |
dc.identifier.citedreference | Rattanawong, P., Vutthikraivit, W., Charoensri, A., Jongraksak, T., Prombandankul, A., Kanjanahattakij, N., … Ngarmukos, T. ( 2016 ). Fever‐induced Brugada syndrome is more common than previously suspected: A cross‐sectional study from an endemic area. Annals of Noninvasive Electrocardiology, 21 ( 2 ), 136 – 141. https://doi.org/10.1111/anec.12288 | |
dc.identifier.citedreference | Rook, M. B., Bezzina Alshinawi, C., Groenewegen, W. A., van Gelder, I. C., van Ginneken, A. C., Jongsma, H. J., … Wilde, A. A. ( 1999 ). Human SCN5A gene mutations alter cardiac sodium channel kinetics and are associated with the Brugada syndrome. Cardiovascular Research, 44 ( 3 ), 507 – 517. https://doi.org/10.1016/S0008-6363(99)00350-8 | |
dc.identifier.citedreference | Royer, A., van Veen, T. A., Le Bouter, S., Marionneau, C., Griol‐Charhbili, V., Leoni, A. L., … Charpentier, F. ( 2005 ). Mouse model of SCN5A‐linked hereditary Lenegre’s disease: Age‐related conduction slowing and myocardial fibrosis. Circulation, 111 ( 14 ), 1738 – 1746. https://doi.org/10.1161/01.CIR.0000160853.19867.61 | |
dc.identifier.citedreference | Smits, J. P., Eckardt, L., Probst, V., Bezzina, C. R., Schott, J. J., Remme, C. A., … Wilde, A. A. ( 2002 ). Genotype‐phenotype relationship in Brugada syndrome: Electrocardiographic features differentiate SCN5A‐related patients from non‐SCN5A‐related patients. Journal of the American College of Cardiology, 40 ( 2 ), 350 – 356. https://doi.org/10.1016/S0735-1097(02)01962-9 | |
dc.identifier.citedreference | Sommariva, E., Pappone, C., Martinelli Boneschi, F., Di Resta, C., Rosaria Carbone, M., Salvi, E., … Benedetti, S. ( 2013 ). Genetics can contribute to the prognosis of Brugada syndrome: A pilot model for risk stratification. European Journal of Human Genetics, 21 ( 9 ), 911 – 917. https://doi.org/10.1038/ejhg.2012.289 | |
dc.identifier.citedreference | Sonoda, K., Ohno, S., Ozawa, J., Hayano, M., Hattori, T., Kobori, A., … Horie, M. ( 2018 ). Copy number variations of SCN5A in Brugada syndrome. Heart Rhythm: the Official Journal of the Heart Rhythm Society, 15 ( 8 ), 1179 – 1188. https://doi.org/10.1016/j.hrthm.2018.03.033 | |
dc.identifier.citedreference | Stang, A. ( 2010 ). Critical evaluation of the Newcastle‐Ottawa scale for the assessment of the quality of nonrandomized studies in meta‐analyses. European Journal of Epidemiology, 25 ( 9 ), 603 – 605. https://doi.org/10.1007/s10654-010-9491-z | |
dc.identifier.citedreference | Sterne, J. A., & Egger, M. ( 2001 ). Funnel plots for detecting bias in meta‐analysis: Guidelines on choice of axis. Journal of Clinical Epidemiology, 54 ( 10 ), 1046 – 1055. https://doi.org/10.1016/S0895-4356(01)00377-8 | |
dc.identifier.citedreference | Yamagata, K., Horie, M., Aiba, T., Ogawa, S., Aizawa, Y., Ohe, T., … Shimizu, W. ( 2017 ). Genotype‐phenotype correlation of SCN5A mutation for the clinical and electrocardiographic characteristics of probands with Brugada syndrome: A Japanese Multicenter Registry. Circulation, 135 ( 23 ), 2255 – 2270. https://doi.org/10.1161/circulationaha.117.027983 | |
dc.identifier.citedreference | Yokokawa, M., Noda, T., Okamura, H., Satomi, K., Suyama, K., Kurita, T., … Shimizu, W. ( 2007 ). Comparison of long‐term follow‐up of electrocardiographic features in Brugada syndrome between the SCN5A‐positive probands and the SCN5A‐negative probands. American Journal of Cardiology, 100 ( 4 ), 649 – 655. https://doi.org/10.1016/j.amjcard.2007.03.078 | |
dc.identifier.citedreference | Adler, A., Rosso, R., Chorin, E., Havakuk, O., Antzelevitch, C., & Viskin, S. ( 2016 ). Risk stratification in Brugada syndrome: Clinical characteristics, electrocardiographic parameters, and auxiliary testing. Heart Rhythm: the Official Journal of the Heart Rhythm Society, 13 ( 1 ), 299 – 310. https://doi.org/10.1016/j.hrthm.2015.08.038 | |
dc.identifier.citedreference | Andorin, A., Behr, E. R., Denjoy, I., Crotti, L., Dagradi, F., Jesel, L., … Probst, V. ( 2016 ). Impact of clinical and genetic findings on the management of young patients with Brugada syndrome. Heart Rhythm: the Official Journal of the Heart Rhythm Society, 13 ( 6 ), 1274 – 1282. https://doi.org/10.1016/j.hrthm.2016.02.013 | |
dc.identifier.citedreference | Brugada, P., & Brugada, J. ( 1992 ). Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome. Journal of the American College of Cardiology, 20 ( 6 ), 1391 – 1396. https://doi.org/10.1016/0735-1097(92)90253-J | |
dc.identifier.citedreference | Chen, Q., Kirsch, G. E., Zhang, D., Brugada, R., Brugada, J., Brugada, P., … Wang, Q. ( 1998 ). Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature, 392 ( 6673 ), 293 – 296. https://doi.org/10.1038/32675 | |
dc.identifier.citedreference | Conte, G., Sieira, J., Ciconte, G., de Asmundis, C., Chierchia, G. B., Baltogiannis, G., … Brugada, P. ( 2015 ). Implantable cardioverter‐defibrillator therapy in Brugada syndrome: A 20‐year single‐center experience. Journal of the American College of Cardiology, 65 ( 9 ), 879 – 888. https://doi.org/10.1016/j.jacc.2014.12.031 | |
dc.identifier.citedreference | DerSimonian, R., & Laird, N. ( 1986 ). Meta‐analysis in clinical trials. Controlled Clinical Trials, 7 ( 3 ), 177 – 188. https://doi.org/10.1016/0197-2456(86)90046-2 | |
dc.identifier.citedreference | Eckardt, L., Probst, V., Smits, J. P., Bahr, E. S., Wolpert, C., Schimpf, R., … Wilde, A. A. ( 2005 ). Long‐term prognosis of individuals with right precordial ST‐segment‐elevation Brugada syndrome. Circulation, 111 ( 3 ), 257 – 263. https://doi.org/10.1161/01.CIR.0000153267.21278.8D | |
dc.identifier.citedreference | Gehi, A. K., Duong, T. D., Metz, L. D., Gomes, J. A., & Mehta, D. ( 2006 ). Risk stratification of individuals with the Brugada electrocardiogram: A meta‐analysis. Journal of Cardiovascular Electrophysiology, 17 ( 6 ), 577 – 583. https://doi.org/10.1111/j.1540-8167.2006.00455.x | |
dc.identifier.citedreference | George, A. L. Jr ( 2005 ). Inherited disorders of voltage‐gated sodium channels. Journal of Clinical Investigation, 115 ( 8 ), 1990 – 1999. https://doi.org/10.1172/JCI25505 | |
dc.identifier.citedreference | Higgins, J. P., Thompson, S. G., Deeks, J. J., & Altman, D. G. ( 2003 ). Measuring inconsistency in meta‐analyses. BMJ, 327 ( 7414 ), 557 – 560. https://doi.org/10.1136/bmj.327.7414.557 | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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