L‐proline and betaine inhibit extracellular enzymes mediated abeta 1‐42 aggregation, oxidative stress, and toxicity
dc.contributor.author | Ismail, Tania | |
dc.contributor.author | Vancha, Sushma Reddy | |
dc.contributor.author | Kanapathipillai, Mathumai | |
dc.date.accessioned | 2019-01-15T20:31:29Z | |
dc.date.available | 2020-01-06T16:40:59Z | en |
dc.date.issued | 2018-11 | |
dc.identifier.citation | Ismail, Tania; Vancha, Sushma Reddy; Kanapathipillai, Mathumai (2018). "L‐proline and betaine inhibit extracellular enzymes mediated abeta 1‐42 aggregation, oxidative stress, and toxicity." Peptide Science 110(6): n/a-n/a. | |
dc.identifier.issn | 2475-8817 | |
dc.identifier.issn | 2475-8817 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/147177 | |
dc.description.abstract | Extracellular amyloid plaques are characteristics of Alzheimer’s disease (AD). The amyloid plaques mainly consist of amyloid‐β (abeta) fragments. Extracellular biomolecules play a key role in abeta aggregation and subsequent plaque formation during AD. Among them, extracellular enzymes are known to induce abeta aggregation by catalyzing the crosslinking of abeta proteins. Although several therapeutic strategies have been studied to combat AD, studies to treat extracellular enzymes mediated abeta aggregation and toxicity is not explored in detail yet. Here we study the potential of osmolyte molecules l‐proline and betaine to inhibit the abeta aggregation and toxicity promoted by extracellular enzymes transglutaminase and lysyl oxidase in vitro. Results reveal that l‐proline and betaine have the potential to inhibit extracellular matrix enzymes mediated abeta aggregation/fibril formation and toxicity and oxidative stress in brain endothelial cells. Hence osmolytes could have the potential to modulate the effects of extracellular molecules during AD. | |
dc.publisher | John Wiley & Sons, Inc. | |
dc.subject.other | l‐proline | |
dc.subject.other | betaine | |
dc.subject.other | extracellular enzymes | |
dc.subject.other | alzheimer’s | |
dc.subject.other | aggregation | |
dc.subject.other | abeta peptide | |
dc.title | L‐proline and betaine inhibit extracellular enzymes mediated abeta 1‐42 aggregation, oxidative stress, and toxicity | |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Biological Chemistry | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/147177/1/pep224093_am.pdf | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/147177/2/pep224093.pdf | |
dc.identifier.doi | 10.1002/pep2.24093 | |
dc.identifier.source | Peptide Science | |
dc.identifier.citedreference | S. Y. Kook, H. Seok Hong, M. Moon, I. Mook‐Jung, Tissue Barriers 2013, 1, e23993. | |
dc.identifier.citedreference | D. M. Hartley, C. Zhao, A. C. Speier, G. A. Woodard, S. Li, Z. Li, T. Walz, J. Biol. Chem. 2008, 283, 16790. | |
dc.identifier.citedreference | L. G. Paleg, G. R. Stewart, J. W. Bradbeer, Plant Physiol. 1984, 75, 974. | |
dc.identifier.citedreference | S. Choudhary, N. Kishore, R. V. Hosur, Sci. Rep. 2015, 5, 17599. | |
dc.identifier.citedreference | M. Dasgupta, N. Kishore, PLoS One 2017, 12, e0172208. | |
dc.identifier.citedreference | H. Wang, J. A. Joseph, Free Radic. Biol. Med. 1999, 27, 612. | |
dc.identifier.citedreference | A. Gomes, E. Fernandes, J. L. Lima, J. Biochem. Biophys. Methods 2005, 65, 45. | |
dc.identifier.citedreference | A. M. Swomley, S. Forster, J. T. Keeney, J. Triplett, Z. Zhang, R. Sultana, D. A. Butterfield, Biochim. Biophys. Acta 2014, 1842, 1248. | |
dc.identifier.citedreference | D. A. Butterfield, A. M. Swomley, R. Sultana, Antioxid. Redox Signal. 2013, 19, 823. | |
dc.identifier.citedreference | S. W. French, A. S. Mendoza, Y. Peng, Exp. Mol. Pathol. 2016, 100, 426. | |
dc.identifier.citedreference | X. Liang, L. Zhang, S. K. Natarajan, D. F. Becker, Antioxid. Redox Signal. 2013, 19, 998. | |
dc.identifier.citedreference | W. Wan, L. Cao, L. Liu, C. Zhang, B. Kalionis, X. Tai, Y. Li, S. Xia, J. Neurochem. 2015, 134, 382. | |
dc.identifier.citedreference | S. Marco, S. D. Skaper, Neurosci. Lett. 2006, 401, 219. | |
dc.identifier.citedreference | W. F. Goure, G. A. Krafft, J. Jerecic, F. Hefti, Alzheimers Res. Ther. 2014, 6, 42. | |
dc.identifier.citedreference | E. Hubin, N. A. van Nuland, K. Broersen, K. Pauwels, Cell. Mol. Life Sci. 2014, 71, 3507. | |
dc.identifier.citedreference | M. C. Lampi, C. A. Reinhart‐King, Sci. Transl. Med. 2018, 10, eaao0475. | |
dc.identifier.citedreference | M. M. Wilhelmus, A. M. van Dam, B. Drukarch, Eur. J. Pharmacol. 2008, 585, 464. | |
dc.identifier.citedreference | Z. Ignatova, L. M. Gierasch, Methods Enzymol. 2007, 428, 355. | |
dc.identifier.citedreference | M. F. Roberts, Saline Syst. 2005, 1, 5. | |
dc.identifier.citedreference | P. H. Yancey, J. Exp. Biol. 2005, 208, 2819. | |
dc.identifier.citedreference | A. R. Im, Y. H. Kim, M. R. Uddin, S. Chae, H. W. Lee, Y. H. Kim, Y. S. Kim, M. Y. Lee, Cell. Mol. Neurobiol. 2013, 33, 625. | |
dc.identifier.citedreference | F. Macchi, M. Eisenkolb, H. Kiefer, D. E. Otzen, Int. J. Mol. Sci. 2012, 13, 3801. | |
dc.identifier.citedreference | G. Bitan, M. D. Kirkitadze, A. Lomakin, S. S. Vollers, G. B. Benedek, D. B. Teplow, Proc. Natl. Acad. Sci. U. S. A. 2003, 100, 330. | |
dc.identifier.citedreference | J. Drake, C. D. Link, D. A. Butterfield, Neurobiol. Aging 2003, 24, 415. | |
dc.identifier.citedreference | M. Chen, H. L. Fernandez, Front. Biosci. 2001, 6, E1. | |
dc.identifier.citedreference | V. J. De‐Paula, M. Radanovic, B. S. Diniz, O. V. Forlenza, Subcell. Biochem. 2012, 65, 329. | |
dc.identifier.citedreference | M. S. Wolfe, Int. Immunopharmacol. 2002, 2, 1919. | |
dc.identifier.citedreference | S. A. Funke, D. Willbold, Curr. Pharm. Des. 2012, 18, 755. | |
dc.identifier.citedreference | H. Li, F. Rahimi, G. Bitan, ACS Chem. Neurosci. 2016, 7, 845. | |
dc.identifier.citedreference | J. Caceres, E. Brandan, J. Cell. Biochem. 1997, 65, 145. | |
dc.identifier.citedreference | R. Naylor, A. F. Hill, K. J. Barnham, Eur. Biophys. J. 2008, 37, 265. | |
dc.identifier.citedreference | R. Salza, C. Lethias, S. Ricard‐Blum, J. Alzheimers Dis. 2017, 56, 991. | |
dc.identifier.citedreference | M. M. Wilhelmus, J. G. Bol, S. G. van Duinen, B. Drukarch, Exp. Gerontol. 2013, 48, 109. | |
dc.identifier.citedreference | D. S. Wang, D. W. Dickson, J. S. Malter, Int. J. Clin. Exp. Pathol. 2008, 1, 5. | |
dc.identifier.citedreference | G. V. Johnson, T. M. Cox, J. P. Lockhart, M. D. Zinnerman, M. L. Miller, R. E. Powers, Brain Res. 1997, 751, 323. | |
dc.identifier.citedreference | G. M. Gilad, H. M. Kagan, V. H. Gilad, Neurosci. Lett. 2005, 376, 210. | |
dc.identifier.citedreference | M. de Jager, B. van der Wildt, E. Schul, J. G. Bol, S. G. van Duinen, B. Drukarch, M. M. Wilhelmus, Neurobiol. Aging 2013, 34, 1159. | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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