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Volumetric 18F‐FDG‐PET parameters as predictors of locoregional failure in low‐risk HPV‐related oropharyngeal cancer after definitive chemoradiation therapy
dc.contributor.authorChotchutipan, Thong
dc.contributor.authorRosen, Benjamin S.
dc.contributor.authorHawkins, Peter G.
dc.contributor.authorLee, Jae Y.
dc.contributor.authorSaripalli, Anjali L.
dc.contributor.authorThakkar, Dharmesh
dc.contributor.authorEisbruch, Avraham
dc.contributor.authorEl Naqa, Issam
dc.contributor.authorMierzwa, Michelle L.
dc.date.accessioned2019-02-12T20:23:44Z
dc.date.available2020-04-01T15:06:24Zen
dc.date.issued2019-02
dc.identifier.citationChotchutipan, Thong; Rosen, Benjamin S.; Hawkins, Peter G.; Lee, Jae Y.; Saripalli, Anjali L.; Thakkar, Dharmesh; Eisbruch, Avraham; El Naqa, Issam; Mierzwa, Michelle L. (2019). "Volumetric 18F‐FDG‐PET parameters as predictors of locoregional failure in low‐risk HPV‐related oropharyngeal cancer after definitive chemoradiation therapy." Head & Neck 41(2): 366-373.
dc.identifier.issn1043-3074
dc.identifier.issn1097-0347
dc.identifier.urihttps://hdl.handle.net/2027.42/147800
dc.description.abstractBackgroundWe sought to investigate the prognostic value of volumetric positron emission tomography (PET) parameters in patients with human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (OPSCC) and a ≤10 pack‐year smoking history treated with chemoradiation.MethodsA total of 142 patients were included. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis (TLG) of the primary tumor, involved regional lymph nodes, and total lesion were calculated. Cox proportional hazard modeling was used to evaluate associations of clinical and PET parameters with locoregional failure‐free survival (LRFFS), distant metastasis‐free survival (DMFS), and overall survival (OS).ResultsOn univariate analysis, volumetric PET parameters were significantly associated with all endpoints, and 8th edition American Joint Committee on Cancer/Union Internationale Contre le Cancer staging was significantly associated with DMFS and OS. On multivariate analysis, total lesion TLG was significantly associated with LRFFS, while staging was most significantly prognostic for DMFS and OS.ConclusionVolumetric PET parameters are uniquely prognostic of LRFFS in low‐risk HPV‐related OPSCC and may be useful for directing de‐intensification strategies.
dc.publisherJohn Wiley & Sons, Inc.
dc.subject.otherOPSCC
dc.subject.otherTNM staging
dc.subject.otherFDG‐PET
dc.subject.otherlocal control
dc.subject.otherradiation oncology
dc.titleVolumetric 18F‐FDG‐PET parameters as predictors of locoregional failure in low‐risk HPV‐related oropharyngeal cancer after definitive chemoradiation therapy
dc.typeArticleen_US
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelOtolaryngology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/147800/1/hed25505_am.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/147800/2/hed25505.pdf
dc.identifier.doi10.1002/hed.25505
dc.identifier.sourceHead & Neck
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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