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Heterotopic Ossification: A Comprehensive Review
dc.contributor.authorMeyers, Carolyn
dc.contributor.authorLisiecki, Jeffrey
dc.contributor.authorMiller, Sarah
dc.contributor.authorLevin, Adam
dc.contributor.authorFayad, Laura
dc.contributor.authorDing, Catherine
dc.contributor.authorSono, Takashi
dc.contributor.authorMcCarthy, Edward
dc.contributor.authorLevi, Benjamin
dc.contributor.authorJames, Aaron W
dc.date.accessioned2019-05-31T18:25:50Z
dc.date.available2020-06-01T14:50:01Zen
dc.date.issued2019-04
dc.identifier.citationMeyers, Carolyn; Lisiecki, Jeffrey; Miller, Sarah; Levin, Adam; Fayad, Laura; Ding, Catherine; Sono, Takashi; McCarthy, Edward; Levi, Benjamin; James, Aaron W (2019). "Heterotopic Ossification: A Comprehensive Review." JBMR Plus 3(4): n/a-n/a.
dc.identifier.issn2473-4039
dc.identifier.issn2473-4039
dc.identifier.urihttps://hdl.handle.net/2027.42/149244
dc.description.abstractHeterotopic ossification (HO) is a diverse pathologic process, defined as the formation of extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair process gone awry and is a common complication of trauma and surgery. This comprehensive review seeks to synthesize the clinical, pathoetiologic, and basic biologic features of HO, including nongenetic and genetic forms. First, the clinical features, radiographic appearance, histopathologic diagnosis, and current methods of treatment are discussed. Next, current concepts regarding the mechanistic bases for HO are discussed, including the putative cell types responsible for HO formation, the inflammatory milieu and other prerequisite “niche” factors for HO initiation and propagation, and currently available animal models for the study of HO of this common and potentially devastating condition. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherHETEROTOPIC BONE
dc.subject.otherECTOPIC BONE
dc.subject.otherMYOSITIS OSSIFICANS
dc.subject.otherFIBRODYSPLASIA OSSIFICANS PROGRESSIVA
dc.titleHeterotopic Ossification: A Comprehensive Review
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelEndocrinology
dc.subject.hlbsecondlevelGeriatric Medicine
dc.subject.hlbsecondlevelRheumatology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/149244/1/jbm410172_am.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/149244/2/jbm410172.pdf
dc.identifier.doi10.1002/jbm4.10172
dc.identifier.sourceJBMR Plus
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