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Zoledronate treatment duration is linked to bisphosphonate‐related osteonecrosis of the jaw prevalence in rice rats with generalized periodontitis
dc.contributor.authorMesser, Jonathan G.
dc.contributor.authorJiron, Jessica M.
dc.contributor.authorMendieta Calle, Jorge L.
dc.contributor.authorCastillo, Evelyn J.
dc.contributor.authorIsrael, Ronnie
dc.contributor.authorPhillips, Ean G.
dc.contributor.authorYarrow, Joshua F.
dc.contributor.authorPoznak, Catherine
dc.contributor.authorKesavalu, Lakshmyya
dc.contributor.authorKimmel, Donald B.
dc.contributor.authorAguirre, J. Ignacio
dc.date.accessioned2019-05-31T18:27:05Z
dc.date.available2020-07-01T17:47:46Zen
dc.date.issued2019-05
dc.identifier.citationMesser, Jonathan G.; Jiron, Jessica M.; Mendieta Calle, Jorge L.; Castillo, Evelyn J.; Israel, Ronnie; Phillips, Ean G.; Yarrow, Joshua F.; Poznak, Catherine; Kesavalu, Lakshmyya; Kimmel, Donald B.; Aguirre, J. Ignacio (2019). "Zoledronate treatment duration is linked to bisphosphonate‐related osteonecrosis of the jaw prevalence in rice rats with generalized periodontitis." Oral Diseases 25(4): 1116-1135.
dc.identifier.issn1354-523X
dc.identifier.issn1601-0825
dc.identifier.urihttps://hdl.handle.net/2027.42/149302
dc.description.abstractObjectivesTo determine the extent that zoledronate (ZOL) dose and duration is associated with bisphosphonate‐related osteonecrosis of the jaw (BRONJ) prevalence in rice rats with generalized periodontitis (PD), characterize structural and tissue‐level features of BRONJ‐like lesions in this model, and examine the specific anti‐resorptive role of ZOL in BRONJ.Materials and MethodsRice rats (n = 228) consumed high sucrose‐casein diet to enhance generalized PD. Groups of rats received 0, 8, 20, 50 or 125 µg/kg IV ZOL/4 weeks encompassing osteoporosis and oncology ZOL doses. Rats from each dose group (n = 9–16) were necropsied after 12, 18, 24 and 30 weeks of treatment. BRONJ‐like lesion prevalence and tissue‐level features were assessed grossly, histopathologically and by MicroCT. ZOL bone turnover effects were assessed by femoral peripheral quantitative computed tomography, serum bone turnover marker ELISAs and osteoclast immunolabelling.ResultsPrevalence of BRONJ‐like lesions was significantly associated with (a) ZOL treatment duration, but plateaued at the lowest oncologic dose, and (b) there was a similar dose‐related plateau in the systemic anti‐resorptive effect of ZOL. ZOL and BRONJ‐like lesions also altered the structural and tissue‐level features of the jaw.ConclusionThe relationship between BRONJ‐like lesion prevalence and ZOL dose and duration varies depending on the co‐ or pre‐existing oral risk factor. At clinically relevant doses of ZOL, BRONJ‐like lesions are associated with anti‐resorptive activity.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherhistopathology
dc.subject.otherpreclinical
dc.subject.othertoxicology
dc.subject.otherhigh sucrose‐casein diet
dc.subject.otheranti‐resorptives
dc.titleZoledronate treatment duration is linked to bisphosphonate‐related osteonecrosis of the jaw prevalence in rice rats with generalized periodontitis
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDentistry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/149302/1/odi13052.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/149302/2/odi13052_am.pdf
dc.identifier.doi10.1111/odi.13052
dc.identifier.sourceOral Diseases
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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