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The impact of intraoperative fluid management during laparoscopic donor nephrectomy on donor and recipient outcomes

dc.contributor.authorWilliams, Aaron M.
dc.contributor.authorKumar, Sathish S.
dc.contributor.authorBhatti, Umar F.
dc.contributor.authorBiesterveld, Ben E.
dc.contributor.authorKathawate, Ranganath G.
dc.contributor.authorSung, Randall S.
dc.contributor.authorWoodside, Kenneth J.
dc.contributor.authorEnglesbe, Michael J.
dc.contributor.authorAlameddine, Mitchell B.
dc.contributor.authorWaits, Seth A.
dc.date.accessioned2019-07-03T19:56:13Z
dc.date.availableWITHHELD_12_MONTHS
dc.date.available2019-07-03T19:56:13Z
dc.date.issued2019-06
dc.identifier.citationWilliams, Aaron M.; Kumar, Sathish S.; Bhatti, Umar F.; Biesterveld, Ben E.; Kathawate, Ranganath G.; Sung, Randall S.; Woodside, Kenneth J.; Englesbe, Michael J.; Alameddine, Mitchell B.; Waits, Seth A. (2019). "The impact of intraoperative fluid management during laparoscopic donor nephrectomy on donor and recipient outcomes." Clinical Transplantation 33(6): n/a-n/a.
dc.identifier.issn0902-0063
dc.identifier.issn1399-0012
dc.identifier.urihttps://hdl.handle.net/2027.42/149691
dc.description.abstractBackgroundIntraoperative fluid management during laparoscopic donor nephrectomy (LDN) may have a significant effect on donor and recipient outcomes. We sought to quantify variability in fluid management and investigate its impact on donor and recipient outcomes.MethodsA retrospective review of patients who underwent LDN from July 2011 to January 2016 with paired kidney recipients at a single center was performed. Patients were divided into tertiles of intraoperative fluid management (standard, high, and aggressive). Donor and recipient demographics, intraoperative data, and postoperative outcomes were analyzed.ResultsOverall, 413 paired kidney donors and recipients were identified. Intraoperative fluid management (mL/h) was highly variable with no correlation to donor weight (kg) (R = 0.017). The aggressive fluid management group had significantly lower recipient creatinine levels on postoperative day 1. However, no significant differences were noted in creatinine levels out to 6 months between groups. No significant differences were noted in recipient postoperative complications, graft loss, and death. There was a significant increase (P < 0.01) in the number of total donor complications in the aggressive fluid management group.ConclusionsAggressive fluid management during LDN does not improve recipient outcomes and may worsen donor outcomes compared to standard fluid management.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherrecipient outcomes
dc.subject.otherfluid status
dc.subject.otherfluid directed management
dc.subject.otherintraoperative fluid management
dc.subject.otherlaparoscopic donor nephrectomy
dc.titleThe impact of intraoperative fluid management during laparoscopic donor nephrectomy on donor and recipient outcomes
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMedicine (General)
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/149691/1/ctr13542_am.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/149691/2/ctr13542.pdf
dc.identifier.doi10.1111/ctr.13542
dc.identifier.sourceClinical Transplantation
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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