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Emerging Trends in Informationâ Driven Engineering of Complex Biological Systems

dc.contributor.authorSteier, Anke
dc.contributor.authorMuñiz, Ayşe
dc.contributor.authorNeale, Dylan
dc.contributor.authorLahann, Joerg
dc.date.accessioned2019-07-03T19:56:54Z
dc.date.availableWITHHELD_12_MONTHS
dc.date.available2019-07-03T19:56:54Z
dc.date.issued2019-06
dc.identifier.citationSteier, Anke; Muñiz, Ayşe ; Neale, Dylan; Lahann, Joerg (2019). "Emerging Trends in Informationâ Driven Engineering of Complex Biological Systems." Advanced Materials 31(26): n/a-n/a.
dc.identifier.issn0935-9648
dc.identifier.issn1521-4095
dc.identifier.urihttps://hdl.handle.net/2027.42/149723
dc.description.abstractSynthetic biological systems are used for a myriad of applications, including tissue engineered constructs for in vivo use and microengineered devices for in vitro testing. Recent advances in engineering complex biological systems have been fueled by opportunities arising from the combination of bioinspired materials with biological and computational tools. Driven by the availability of large datasets in the â omicsâ era of biology, the design of the next generation of tissue equivalents will have to integrate information from singleâ cell behavior to whole organ architecture. Herein, recent trends in combining multiscale processes to enable the design of the next generation of biomaterials are discussed. Any successful microprocessing pipeline must be able to integrate hierarchical sets of information to capture key aspects of functional tissue equivalents. Microâ and biofabrication techniques that facilitate hierarchical control as well as emerging polymer candidates used in these technologies are also reviewed.The engineering of complex biological systems relies on pioneering new tissue designed constructs and microengineered devices to advance regenerative medicine and disease modeling. Modern advances in microâ and biofabrication are fueled by the combination of bioinspired materials with biological and computational tools. The integration of multiscale approaches is discussed to enable nextâ generation biomaterial design.
dc.publisherSpringer
dc.publisherWiley Periodicals, Inc.
dc.subject.othertissues engineering
dc.subject.other3D microenvironments
dc.subject.otherbiomateriomics
dc.subject.othermicroprocessing
dc.subject.otherpolymers
dc.titleEmerging Trends in Informationâ Driven Engineering of Complex Biological Systems
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMaterials Science and Engineering
dc.subject.hlbsecondlevelEngineering (General)
dc.subject.hlbtoplevelEngineering
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/149723/1/adma201806898_am.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/149723/2/adma201806898.pdf
dc.identifier.doi10.1002/adma.201806898
dc.identifier.sourceAdvanced Materials
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