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A pathologic twoâ way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunity
dc.contributor.authorWarheit‐niemi, Helen I
dc.contributor.authorHult, Elissa M
dc.contributor.authorMoore, Bethany B
dc.date.accessioned2019-07-03T19:57:39Z
dc.date.available2020-03-03T21:29:36Zen
dc.date.issued2019
dc.identifier.citationWarheit‐niemi, Helen I ; Hult, Elissa M; Moore, Bethany B (2019). "A pathologic twoâ way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunity." Clinical & Translational Immunology (6): n/a-n/a.
dc.identifier.issn2050-0068
dc.identifier.issn2050-0068
dc.identifier.urihttps://hdl.handle.net/2027.42/149765
dc.description.abstractLung fibrosis is characterised by the accumulation of extracellular matrix within the lung and is secondary to both known and unknown aetiologies. This accumulation of scar tissue limits gas exchange causing respiratory insufficiency. The pathogenesis of lung fibrosis is poorly understood, but immunologicâ based treatments have been largely ineffective. Despite this, accumulating evidence suggests that innate immune cells and receptors play important modulatory roles in the initiation and propagation of the disease. Paradoxically, while innate immune signalling may be important for the pathogenesis of fibrosis, there is also evidence to suggest that innate immune function against pathogens may be impaired, leading to dysregulated and/or impaired host defence. This review summarises the evidence for this pathologic twoâ way street, highlights new concepts of pathogenesis and recommends future directions for research emphasis.Innate immunity has been shown to promote the development of lung injury and fibrosis through a myriad of mechanisms. New information also suggests that the fibrotic milieu can impair the function of innate immune cells, leading to further infection, dysbiosis and fibrotic progression.
dc.publisherWiley Periodicals, Inc.
dc.subject.othermacrophage
dc.subject.otherneutrophil
dc.subject.otherTollâ like receptors
dc.subject.otherhost defence
dc.subject.othercollagen
dc.subject.otherbacteria
dc.titleA pathologic twoâ way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunity
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMicrobiology and Immunology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/149765/1/cti21065.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/149765/2/cti21065_am.pdf
dc.identifier.doi10.1002/cti2.1065
dc.identifier.sourceClinical & Translational Immunology
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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