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Intratumor genetic heterogeneity in squamous cell carcinoma of the oral cavity
dc.contributor.authorZandberg, Dan P.
dc.contributor.authorTallon, Luke J.
dc.contributor.authorNagaraj, Sushma
dc.contributor.authorSadzewicz, Lisa K.
dc.contributor.authorZhang, Yuji
dc.contributor.authorStrome, Maxwell B.
dc.contributor.authorZhao, Xuechu E.
dc.contributor.authorVavikolanu, Kranthi
dc.contributor.authorZhang, Xiaoyu
dc.contributor.authorPapadimitriou, John C.
dc.contributor.authorHubbard, Fleesie A.
dc.contributor.authorBentzen, Søren M.
dc.contributor.authorStrome, Scott E.
dc.contributor.authorFraser, Claire M.
dc.date.accessioned2019-08-09T17:14:06Z
dc.date.availableWITHHELD_13_MONTHS
dc.date.available2019-08-09T17:14:06Z
dc.date.issued2019-08
dc.identifier.citationZandberg, Dan P.; Tallon, Luke J.; Nagaraj, Sushma; Sadzewicz, Lisa K.; Zhang, Yuji; Strome, Maxwell B.; Zhao, Xuechu E.; Vavikolanu, Kranthi; Zhang, Xiaoyu; Papadimitriou, John C.; Hubbard, Fleesie A.; Bentzen, Søren M. ; Strome, Scott E.; Fraser, Claire M. (2019). "Intratumor genetic heterogeneity in squamous cell carcinoma of the oral cavity." Head & Neck 41(8): 2514-2524.
dc.identifier.issn1043-3074
dc.identifier.issn1097-0347
dc.identifier.urihttps://hdl.handle.net/2027.42/150549
dc.description.abstractBackgroundWe sought to evaluate intratumor heterogeneity in squamous cell carcinoma of the oral cavity (OCC) and specifically determine the effect of physical separation and histologic differentiation within the same tumor.MethodsWe performed whole exome sequencing on five biopsy sites—two from well‐differentiated, two from poorly differentiated regions, and one from normal parenchyma—from five primary OCC specimens.ResultsWe found high levels of intratumor heterogeneity and, in four primary tumors, identified only 0 to 2 identical mutations in all subsites. We found that the heterogeneity inversely correlated with physical separation and that pairs of well‐differentiated samples were more similar to each other than analogous poorly differentiated specimens. Only TP53 mutations, but not other purported “driver mutations” in head and neck squamous cell carcinoma, were found in multiple biopsy sites.ConclusionThese data highlight the challenges to characterization of the mutational landscape of OCC with single site biopsy and have implications for personalized medicine.
dc.publisherJohn Wiley & Sons, Inc.
dc.subject.othergenetic
dc.subject.otherSCCHN
dc.subject.otheroral cavity
dc.subject.othersquamous cell carcinoma
dc.subject.otherheterogeneity
dc.titleIntratumor genetic heterogeneity in squamous cell carcinoma of the oral cavity
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelOtolaryngology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/150549/1/hed25719.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/150549/2/hed25719_am.pdf
dc.identifier.doi10.1002/hed.25719
dc.identifier.sourceHead & Neck
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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