View Item 

Show simple item record

Basal cell carcinoma of the vulva: a case report and systematic review of the literature
dc.contributor.authorRenati, Sruthi
dc.contributor.authorHenderson, Christopher
dc.contributor.authorAluko, Ashley
dc.contributor.authorBurgin, Susan
dc.date.accessioned2019-08-09T17:14:38Z
dc.date.availableWITHHELD_13_MONTHS
dc.date.available2019-08-09T17:14:38Z
dc.date.issued2019-08
dc.identifier.citationRenati, Sruthi; Henderson, Christopher; Aluko, Ashley; Burgin, Susan (2019). "Basal cell carcinoma of the vulva: a case report and systematic review of the literature." International Journal of Dermatology 58(8): 892-902.
dc.identifier.issn0011-9059
dc.identifier.issn1365-4632
dc.identifier.urihttps://hdl.handle.net/2027.42/150570
dc.description.abstractThe vulva is an unusual site for basal cell carcinoma (BCC). Vulvar BCC accounts for <1% of all BCCs and <5% of all vulvar malignancies. We report the case of an 83 year‐old woman who presented with a 2‐month history of a tender labial growth, with histopathology confirming nodular BCC. We conducted a systematic literature review of the characteristics of reported cases of vulvar BCCs. A comprehensive systematic review of articles indexed for MEDLINE and Embase yielded 96 reports describing 437 patients with 446 BCCs of the vulva. The mean age at presentation was 70 (range 20–100). Most women had no underlying vulvar disease. Approximately 60% of cases were of the nodular subtype. Treatment approach varied widely with over half of cases treated with wide local or local excision. Mohs micrographic surgery (MMS) for vulvar BCC was first reported in 1988 with seven total MMS cases reported. Twenty‐three cases of recurrence have been reported; 21 of these cases after local excision but none following MMS. Vulvar BCC is a rarely reported cancer that affects older women predominantly. MMS represents a promising treatment for BCC in this anatomic location.
dc.publisherWiley Periodicals, Inc.
dc.titleBasal cell carcinoma of the vulva: a case report and systematic review of the literature
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelDermatology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/150570/1/ijd14307.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/150570/2/ijd14307_am.pdf
dc.identifier.doi10.1111/ijd.14307
dc.identifier.sourceInternational Journal of Dermatology
dc.identifier.citedreferenceRegauer S, Nogales FF. Vulvar trichogenic tumors: a comparative study with vulvar basal cell carcinoma. Am J Surg Pathol 2005; 29: 479 – 484.
dc.identifier.citedreferenceSiegler AM, Greene HJ. Basal‐cell carcinoma of the vulva: a report of five cases and a review of the literature. Am J Obstet Gynecol 1951; 62: 1219 – 1224.
dc.identifier.citedreferenceSimkin RJ, Fisher BK. Basal cell epithelioma of the vulva. Obstet Gynecol 1977; 49: 617 – 619.
dc.identifier.citedreferenceSimonsen E, Johnsson JE, Trop C, et al. Basal cell carcinoma of the vulva. Acta Obstet Gynecol Scand 1985; 64: 231 – 234.
dc.identifier.citedreferenceSmith BH, Daily WT. Basal cell carcinoma of the labium minus pudendi. Arch Pathol 1950; 50: 132.
dc.identifier.citedreferenceStaiano JJ, Wong L, Butler J, et al. Flap reconstruction following gynaecological tumour resection for advanced and recurrent disease–a 12 year experience. J Plast Reconstr Aesthet Surg 2009; 62: 346 – 351.
dc.identifier.citedreferenceSuda T, Kakinuma H. Erosive velvety lesion on the vulva–vulvar basal cell carcinoma. Arch Dermatol 2006; 142: 385 – 390.
dc.identifier.citedreferenceSworn MJ, Hammond GT, Buchanan R. Metastatic basal cell carcinoma of the vulva case report. BJOG 1979; 86: 332 – 334.
dc.identifier.citedreferenceTakahashi H. Non‐ulcerative basal cell carcinoma. J Dermatol 2000; 27: 798 – 801.
dc.identifier.citedreferenceThurston JG. Basal‐celled carcinoma of the vulva. J Obstet Gynaecol Br Emp 1951; 58: 465 – 467.
dc.identifier.citedreferenceVakselj A, Bebar S. The role of sentinel lymph node detection in vulvar carcinoma and the experiences at the Institute of Oncology Ljubljana. Radiol Oncol 2007; 41: 167 – 173.
dc.identifier.citedreferenceWard J. Five cases of basal‐cell carcinoma of the vulva. J Obstet Gynaecol Br Emp 1956; 63: 697 – 705.
dc.identifier.citedreferenceWinkelmann SE, Llorens AS. Metastatic basal cell carcinoma of the vulva. Gynecol Oncol 1990; 38: 138 – 140.
dc.identifier.citedreferenceWright JL. Two unusual vulval tumours. N Z Med J 1951; 50: 560 – 565.
dc.identifier.citedreferenceYaghoobi R, Razi T, Feily A. Clinical image: an unusual pigmented basal cell carcinoma arising from vulva. Acta Dermatovenerol Alp Pannonica Adriat 2011; 20: 81 – 82.
dc.identifier.citedreferenceYamagami T, Araki S, Aiko Y, et al. Examination of metastatic basal cell carcinoma. Kurume Med J 1974; 21: 83 – 86.
dc.identifier.citedreferenceZerner J, Fenn ME. Basal cell carcinoma of the vulva. Int J Gynaecol Obstet 1979; 17: 203 – 205.
dc.identifier.citedreferenceJacobs GH, Rippey JJ, Altini M. Prediction of aggressive behavior in basal cell carcinoma. Cancer 1982; 49: 533 – 537.
dc.identifier.citedreferenceRowe DE, Carroll RJ, Day CL Jr. Long‐term recurrence rates in previously untreated (primary) basal cell carcinoma: implications for patient follow‐up. J Dermatol Surg Oncol 1989; 15: 315 – 328.
dc.identifier.citedreferenceGibson GE, Ahmed I. Perianal and genital basal cell carcinoma: a clinicopathologic review of 51 cases. J Am Acad Dermatol 2001; 45: 68 – 71.
dc.identifier.citedreferenceMiller ES, Fairley JA, Neuburg M. Vulvar basal cell carcinoma. Dermatol Surg 1997; 23: 207 – 209.
dc.identifier.citedreferenceSchueller EF. Basal cell cancer of the vulva. Am J Obstet Gynecol 1965; 93: 199 – 208.
dc.identifier.citedreferencePiura B, Rabinovich A, Dgani R. Basal cell carcinoma of the vulva. J Surg Oncol 1999; 70: 172 – 176.
dc.identifier.citedreferenceStiller M, Klein W, Dorman R, et al. Bilateral vulvar basal cell carcinomata. J Am Acad Dermatol 1993; 28: 836 – 838.
dc.identifier.citedreferenceGiuliani M, Di Stefano L, Zoccali G, et al. Gorlin syndrome associated with basal cell carcinoma of the vulva: a case report. Eur J Gynaecol Oncol 2006; 27: 519 – 522.
dc.identifier.citedreferenceAbdelbaqi M, Shackelford RE, Quigley BC, et al. Concurrent Paget’s disease and basal cell carcinoma of the vulva; a case report. Int J Clin Exp Pathol 2012; 5: 592.
dc.identifier.citedreferenceAbell MR. Adenocystic (pseudoadenomatous) basal cell carcinoma of vestibular glands of vulva. Am J Obstet Gynecol 1963; 86: 470 – 482.
dc.identifier.citedreferenceAboul‐Nasr AL. Malignant tumors of the female external genital organs. J Egypt Med Assoc 1961; 44: 809.
dc.identifier.citedreferenceAckles RC, Pratt JP. Basal‐cell carcinoma of the vulva. Am J Obstet Gynecol 1956; 72: 1124 – 1126.
dc.identifier.citedreferenceAdem K, Nassar A. Pathologic quiz case: fine‐needle aspiration of lytic bone lesions in a 63‐year‐old woman. Arch Pathol Lab Med 2004; 128: 819 – 820.
dc.identifier.citedreferenceAmbrosini A, Becagli L, Resta P, et al. Basal cell carcinoma of the vulva. Eur J Gynaecol Oncol 1980; 1: 126 – 128.
dc.identifier.citedreferenceAsuman C, Özlem A, Burçak T, et al. An unusual location of basal cell carcinoma: the clitoris and the vulva. Indian J Dermatol 2008; 53: 192.
dc.identifier.citedreferenceBean SF, Becker FT. Basal cell carcinoma of the vulva: a case report and review of the literature. Arch Dermatol 1968; 98: 284 – 286.
dc.identifier.citedreferenceBenedet JL, Miller DM, Ehlen TG, et al. Basal cell carcinoma of the vulva: clinical features and treatment results in 28 patients. Obstet Gynecol 1997; 90: 765 – 768.
dc.identifier.citedreferenceBetti R, Bruscagin C, Inselvini E, et al. Basal cell carcinomas of covered and unusual sites of the body. Int J Dermatol 1997; 36: 503 – 505.
dc.identifier.citedreferenceBlas Ruperez BR, Margarita Riera MR, Isabel Lazaro IL, et al. Basal cell carcinoma of the vulva. Int J Gynecol Cancer 2013; 23: 1174.
dc.identifier.citedreferenceBoyd WD. Vulval cancer, 1992‐2002 – multidisciplinary care and prognostic factors. Ir Med J 2011; 104: 234 – 236.
dc.identifier.citedreferenceBreen JL, Neubecker RD, Greenwald EA, et al. Basal cell carcinoma of the vulva. Obstet Gynecol 1975; 46: 122 – 129.
dc.identifier.citedreferenceBrown MD, Zachary CB, Grekin RC, et al. Genital tumors: their management by micrographic surgery. J Am Acad Dermatol 1988; 18: 115 – 122.
dc.identifier.citedreferenceBukhari IA, Khalid AJ. Vulvar basal cell carcinoma misdiagnosed for 4 years. Saudi Med J 2006; 27: 93 – 94.
dc.identifier.citedreferenceCaucanas M, Müller G, Vanhooteghem O. Vulvar basal cell carcinoma: report of a case involving the mucosa and review of the literature. Dermatol Reports 2011; 3: e37.
dc.identifier.citedreferenceCelik H, Gurates B, Yavuz A, et al. Vulvar basal cell carcinoma with clitoral involvement. Acta Derm Venereol 2009; 89: 191 – 192.
dc.identifier.citedreferenceCharles AH. Carcinoma of the vulva. Br Med J 1972; 1: 397 – 402.
dc.identifier.citedreferenceCollins PS, Farber GA, Hegre AM. Basal‐cell carcinoma of the vulva. Dermatol Surg 1981; 7: 711 – 714.
dc.identifier.citedreferenceCopas PR, Spann JC, Majmudar B, et al. Basal cell carcinoma of the vulva. A report of four cases. J Reprod Med 1996; 41: 283 – 286.
dc.identifier.citedreferenceCortés J, Marqués A, Torrecabota J, et al. Triple cancer in asymptomatic women. Eur J Gynaecol Oncol 1982; 3: 24.
dc.identifier.citedreferenceCruz‐Jimenez PR, Abell MR. Cutaneous basal cell carcinoma of vulva. Cancer 1975; 36: 1860 – 1868.
dc.identifier.citedreferencede Giorgi V, Massi D, Mannone F, et al. Dermoscopy in vulvar basal cell carcinoma. Arch Dermatol 2007; 143: 423 – 431.
dc.identifier.citedreferencede Giorgi V, Salvini C, Massi D, et al. Vulvar basal cell carcinoma: retrospective study and review of literature. Gynecol Oncol 2005; 97: 192 – 194.
dc.identifier.citedreferenceDeAmbrosis K, Nicklin J, Yong‐Gee S. Basal cell carcinoma of the vulva: a report of four cases. Australas J Dermatol 2008; 49: 213 – 215.
dc.identifier.citedreferenceDeppisch LM. Basal cell carcinoma of the vulva. Mt Sinai J Med 1978; 45: 406 – 410.
dc.identifier.citedreferenceDudzinski MR, Askin FB, Fowler WC Jr. Giant basal cell carcinoma of the vulva. Obstet Gynecol 1984; 63 ( 3 Suppl ): 57S – 60S.
dc.identifier.citedreferenceFeakins RM, Lowe DG. Basal cell carcinoma of the vulva: a clinicopathologic study of 45 cases. Int J Gynecol Pathol 1997; 16: 319 – 324.
dc.identifier.citedreferenceFleury AC, Junkins‐Hopkins JM, Diaz‐Montes T. Vulvar basal cell carcinoma in a 20‐year‐old: case report and review of the literature. Gynecol Oncol Case Rep 2012; 2: 26.
dc.identifier.citedreferenceGarg M, Sharma P, Gupta S, et al. Giant vulvar basal cell carcinoma. BMJ Case Rep 2013; 2013: bcr2013200180.
dc.identifier.citedreferenceGleeson NC, Ruffolo EH, Hoffman MS, et al. Basal cell carcinoma of the vulva with groin node metastasis. Gynecol Oncol 1994; 53: 366 – 368.
dc.identifier.citedreferenceGoldberg DJ. Multiple basal‐cell carcinoma of the vulva. J Dermatol Surg Oncol 1984; 10: 615 – 617.
dc.identifier.citedreferenceGoldberg LH, Robins P. Basal‐cell carcinoma on and around the female genitalia. J Dermatol Surg Oncol 1981; 7: 572 – 575.
dc.identifier.citedreferenceGoldstein AI, Kent DR. All vulvar lesions should be biopsied: basal cell carcinoma—an example of the futility of diagnosis by gross appearance. Am J Obstet Gynecol 1975; 121: 173 – 174.
dc.identifier.citedreferenceGoplerud DR, Keettel WC. Carcinoma of the vulva: a review of 156 cases from the University of Iowa Hospitals. Am J Obstet Gynecol 1968; 100: 550 – 553.
dc.identifier.citedreferenceHoffman MS, Roberts WS, Ruffolo EH. Basal cell carcinoma of the vulva with inguinal lymph node metastases. Gynecol Oncol 1988; 29: 113 – 119.
dc.identifier.citedreferenceIkeda S, Tanaka T, Kawada A. Ultrastructures of 2 cases of malignant vulva tumor after the long lapse of time. Paget’s disease and basal cell carcinoma. J Clin Electron Micro 1984; 17: 789.
dc.identifier.citedreferenceIshizawa T, Mitsuhashi Y, Sugiki H, et al. Basal cell carcinoma within vulvar Paget’s disease. Dermatology 1998; 197: 388 – 390.
dc.identifier.citedreferenceJimenez HT, Penoglio CM, Richart RM. Vulvar basal cell carcinoma with metastasis: a case report. Am J Obstet Gynecol 1975; 121: 285 – 286.
dc.identifier.citedreferenceJurado F, Ramos A, Rivera M, et al. Vulvar basal cell carcinoma mimicking pigmented lichen planus. J Am Acad Dermatol 2014; 70: AB141.
dc.identifier.citedreferenceKacerovská D, Michal M, Kašpírková J, et al. Epidermolytic hyperkeratosis of the vulva associated with basal cell carcinoma in a patient with vaginal condyloma acuminatum and vaginal intraepithelial neoplasia harboring HPV, type 42. Cesk Patol 2014; 50: 92 – 94.
dc.identifier.citedreferenceKanitakis J, Arbona‐Vidal E, Faure M. Extensive pigmented vulvar basal‐cell carcinoma presenting as pruritus in an elderly woman. Dermatol Online J 2011; 17: 8.
dc.identifier.citedreferenceKara M, Colgecen E, Yildirim EN. Vulvar basal cell carcinoma. Indian J Pathol Microbiol 2012; 55: 583.
dc.identifier.citedreferenceKarlgren E. Vulvar malignancies treated at Sabbatsberg Hospital over 20 years. Acta Obstet Gynecol Scand Suppl 1978; 57 ( Suppl 73 ): 3 – 31.
dc.identifier.citedreferenceKelly J. Malignant disease of the vulva. BJOG 1972; 79: 265 – 272.
dc.identifier.citedreferenceKhandeparkar JMS, Dharwadkar AMP, Kamat VB. Basal cell carcinoma of vulva. A case report. Indian J Surg 1982; 44: 265 – 267.
dc.identifier.citedreferenceKimball KJ, Straughn JM, Conner MG, et al. Recurrent basosquamous cell carcinoma of the vulva. Gynecol Oncol 2006; 102: 400 – 402.
dc.identifier.citedreferenceLally A, Charnock F, Clelland C, et al. Multiple vulval basal cell carcinomas. J Eur Acad Dermatol Venereol 2007; 21: 407 – 408.
dc.identifier.citedreferenceLui PC, Fan YS, Lau PP, et al. Vulvar basal cell carcinoma in China: a 13‐year review. Am J Obstet Gynecol 2009; 200: 514.e1.
dc.identifier.citedreferenceMarcus SL. Basal cell and basal‐squamous cell carcinomas of the vulva. Am J Obstet Gynecol 1960; 79: 461 – 469.
dc.identifier.citedreferenceMcAdams AJ, Kistner RW. The relationship of chronic vulvar disease, leukoplakia, and carcinoma in situ to carcinoma of the vulva. Cancer 1958; 11: 740 – 757.
dc.identifier.citedreferenceMerino MJ, LiVolsi VA, Schwartz PE, et al. Adenoid basal cell carcinoma of the vulva. Int J Gynecol Pathol 1982; 1: 299 – 306.
dc.identifier.citedreferenceThomas RH, McGibbon DH, Munro DD. Basal cell carcinoma of the vulva in association with vulval lichen sclerosus et atrophicus. J R Soc Med 1985; 78 ( Suppl 11 ): 16.
dc.identifier.citedreferenceMisago N, Suzuki Y, Miura Y, et al. Giant polypoid basal cell carcinoma with features of fibroepithelioma of Pinkus and extensive cornification. Eur J Dermatol 2004; 14: 272 – 275.
dc.identifier.citedreferenceMizushima J, Ohara K. Basal cell carcinoma of the vulva with lymph node and skin metastasis. J Dermatol 1995; 22: 36 – 42.
dc.identifier.citedreferenceMulayim N, Silver DF, Ocal IT, et al. Vulvar basal cell carcinoma: two unusual presentations and review of the literature. Gynecol Oncol 2002; 85: 532 – 537.
dc.identifier.citedreferenceMulvany NJ, Rayoo M, Allen DG. Basal cell carcinoma of the vulva: a case series. Pathology 2012; 44: 528 – 533.
dc.identifier.citedreferenceNazari Z, Omranipour R. Unusual location of vulvar basal cell carcinoma. J Low Genit Tract Dis 2006; 10: 242 – 244.
dc.identifier.citedreferenceNehal KS, Levine VJ, Ashinoff R. Basal cell carcinoma of the genitalia. Dermatol Surg 1998; 24: 1361 – 1363.
dc.identifier.citedreferenceNel RW. Basal‐cell carcinoma of the vulva‐review of the literature and report of a case. S Afr Med J 1957; 31: 381 – 383.
dc.identifier.citedreferenceNowak RJ. Basal cell carcinoma of the vulva. Obstet Gynecol 1954; 4: 392 – 398.
dc.identifier.citedreferenceOnnis A, Marchetti M, Valente S, et al. Surgical management of invasive vulvar carcinoma: a non mutilating technique. Eur J Gynaecol Oncol 1981; 2: 85.
dc.identifier.citedreferencePalladino VS, Duffy JL, Bures GJ. Basal cell carcinoma of the vulva. Cancer 1969; 24: 460 – 470.
dc.identifier.citedreferencePengsaa P, Pothinam S, Udomthavornsuk B. Vulvar carcinoma at Srinagarind Hospital, Khon Kaen, Thailand. Eur J Gynaecol Oncol 1993; 14: 56 – 62.
dc.identifier.citedreferencePerrone T, Twiggs LB, Adcock LL, et al. Vulvar basal cell carcinoma: an infrequently metastasizing neoplasm. Int J Gynecol Pathol 1987; 6: 152 – 165.
dc.identifier.citedreferencePisani C, Poggiali S, Padova L, et al. Basal cell carcinoma of the vulva. J Eur Acad Dermatol Venereol 2006; 20: 446 – 448.
dc.identifier.citedreferenceRamse OB. Carcinoma of the vulva. Acta Obstet Gynecol Scand 1966; 45 ( S9 ): 127 – 128.
dc.identifier.citedreferenceRodríguez VG, De la Fuente García A, Torres MA, et al. Could cryosurgery be an alternative treatment for basal cell carcinoma of the vulva. Indian Dermatol Online J 2014; 5: 160.
dc.identifier.citedreferenceSaini R, Sarnoff DS. Basal cell carcinoma of the vulva presenting as unilateral pruritus. J Drugs Dermatol 2008; 7: 288 – 290.
dc.identifier.citedreferenceSakai T, Goto M, Kai Y, et al. Vulvar basal cell carcinoma with bone metastasis. J Dermatol 2011; 38: 97 – 100.
dc.identifier.citedreferenceSasajima CC, Vilar E, de Brito EX, et al. Vulvar basal cell carcinoma: an unusual location. J Am Acad Dermatol 2013; 68: AB168.
dc.identifier.citedreferenceSherrard J, Bowen ML. Vulval carcinoma presenting as ‘recurrent herpes’. Int J STD AIDS 1998; 9: 237.
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
ijd14307.pdf
Size:
321.0KB
Format:
PDF
View/Open
Name:
ijd14307_am.pdf
Size:
420.5KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.