Show simple item record

Pediatric malignancies: Is the prechemotherapy left ventricular function normal?

dc.contributor.authorAkam‐venkata, Jyothsna
dc.contributor.authorKadiu, Gilda
dc.contributor.authorGalas, James
dc.contributor.authorAggarwal, Sanjeev
dc.date.accessioned2019-10-30T15:29:57Z
dc.date.availableWITHHELD_12_MONTHS
dc.date.available2019-10-30T15:29:57Z
dc.date.issued2019-09
dc.identifier.citationAkam‐venkata, Jyothsna ; Kadiu, Gilda; Galas, James; Aggarwal, Sanjeev (2019). "Pediatric malignancies: Is the prechemotherapy left ventricular function normal?." Echocardiography 36(9): 1727-1735.
dc.identifier.issn0742-2822
dc.identifier.issn1540-8175
dc.identifier.urihttps://hdl.handle.net/2027.42/151839
dc.description.abstractPurposeWe compared the left ventricular (LV) systolic function in children with cancer before initiation of chemotherapy with matched controls using speckle tracking echocardiography.Methods and resultsIn this retrospective study, we analyzed the echocardiograms of 89 cancer patients before the initiation of chemotherapy and 82 ageâ (8.4 ± 5.2 vs. 8.9 ± 3.9 years, P = .4) and genderâ matched (64% vs. 67%, males, P = .4) healthy controls. Peak systolic LV longitudinal strain (LS) was significantly lower in cancer patients in apical two (â 19.8 ± 3.0 vs. â 23.5 ± 4.0, P < .001), three (â 19.4 ± 3.2 vs. â 23.4 ± 4.0, P < .001), and fourâ chamber views (â 19.7 ± 3.4 vs. â 22.5 ± 3.0, P < .001) compared to controls, as was global longitudinal strain (GLS) (â 19.8 ± 2.7 vs. â 23.4 ± 3.2, P < .001). The prechemotherapy group also had a higher E/e’ ratio compared to controls at the septal (9.3 ± 3.9 vs. 7.9 ± 1.7, P = .005) and lateral annulus (7.9 ± 3.3 vs. 5.9 ± 1.4, P < .001) of the mitral valve. The LV ejection fraction was lower in cancer patients compared to controls (63.5 ± 4.9 vs. 66.8 ± 4.1, P < .001), although still within normal limits. There were no differences in LV myocardial performance index (0.30 ± 0.05 vs. 0.30 ± 0.09, P < .65) and shortening fraction (35.8 ± 5.2 vs. 36.1 ± 6.1, P < 0.75) between the two groups. Subgroup analysis showed no difference in LV GLS between patients with solid tumors (n = 56) and blood cancers (n = 33) (GLS â 19.2 ± 2.9 vs. 19.5 ± 2.4, P > 0.05).ConclusionOur data demonstrating abnormalities in LV GLS in pediatric cancer patients even prior to initiation of chemotherapy are novel and perplexing. Further longitudinal followâ up is required to assess the implications of this abnormal LV function in these patients.
dc.publisherWiley Periodicals, Inc.
dc.subject.otherpediatric echocardiography
dc.subject.othermalignancy
dc.subject.otherstrain
dc.titlePediatric malignancies: Is the prechemotherapy left ventricular function normal?
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelInternal Medicine and Specialties
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/151839/1/echo14461_am.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/151839/2/echo14461.pdf
dc.identifier.doi10.1111/echo.14461
dc.identifier.sourceEchocardiography
dc.identifier.citedreferenceMousavi N, Tan TC, Ali M, Halpern EF, Wang L, Scherrerâ Crosbie M. Echocardiographic parameters of left ventricular size and function as predictors of symptomatic heart failure in patients with a left ventricular ejection fraction of 50â 59% treated with anthracyclines. Eur Heart J Cardiovasc Imaging. 2015; 16 ( 9 ): 977 â 984.
dc.identifier.citedreferenceSawaya H, Sebag IA, Plana JC, et al. Early detection and prediction of cardiotoxicity in chemotherapyâ treated patients. Am J Cardiol. 2011; 107 ( 9 ): 1375 â 1380.
dc.identifier.citedreferencePoterucha JT, Kutty S, Lindquist RK, Li L, Eidem BW. Changes in left ventricular longitudinal strain with anthracycline chemotherapy in adolescents precede subsequent decreased left ventricular ejection fraction. J Am Soc Echocardiogr. 2012; 25 ( 7 ): 733 â 740.
dc.identifier.citedreferenceLorch SM, Ludomirsky A, Singh GK. Maturational and growthâ related changes in left ventricular longitudinal strain and strain rate measured by twoâ dimensional speckle tracking echocardiography in healthy pediatric population. J Am Soc Echocardiogr. 2008; 21 ( 11 ): 1207 â 1215.
dc.identifier.citedreferenceAli MT, Yucel E, Bouras S, et al. Myocardial strain is associated with adverse clinical cardiac events in patients treated with anthracyclines. J Am Soc Echocardiogr. 2016; 29 ( 6 ): pp. 522â 7 e3.
dc.identifier.citedreferenceNegishi K, Negishi T, Hare JL, Haluska BA, Plana JC, Marwick TH. Independent and incremental value of deformation indices for prediction of trastuzumabâ induced cardiotoxicity. J Am Soc Echocardiogr. 2013; 26 ( 5 ): 493 â 498.
dc.identifier.citedreferenceAssuncao B, Handschumacher MD, Brunner AM, et al. Acute leukemia is associated with cardiac alterations before chemotherapy. J Am Soc Echocardiogr. 2017; 30 ( 11 ): 1111 â 1118.
dc.identifier.citedreferenceLang RM, Badano LP, Morâ Avi V, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American society of echocardiography and the European association of cardiovascular imaging. J Am Soc Echocardiogr. 2015; 28 ( 1 ): pp. 1â 39 e14.
dc.identifier.citedreferenceLopez L, Colan SD, Frommelt PC, et al. Recommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the pediatric measurements writing group of the American society of echocardiography pediatric and congenital heart disease council. J Am Soc Echocardiogr. 2010; 23 ( 5 ): pp. 465â 95; quiz 576â 7.
dc.identifier.citedreferenceKhoury PR, Mitsnefes M, Daniels SR, Kimball TR. Ageâ specific reference intervals for indexed left ventricular mass in children. J Am Soc Echocardiogr. 2009; 22 ( 6 ): 709 â 714.
dc.identifier.citedreferenceEidem BW, Sapp BG, Suarez CR, et al. Usefulness of the myocardial performance index for early detection of anthracyclineâ induced cardiotoxicity in children. Am J Cardiol. 2001; 87 ( 9 ): pp. 1120â 2, A9.
dc.identifier.citedreferenceGilladoga AC, Manuel C, Tan C, Wollner N, Sternberg SS, Murphy ML. The cardiotoxicity of adriamycin and daunomycin in children. Cancer. 1976; 37 ( 2 Suppl ): 1070 â 1078.
dc.identifier.citedreferenceCharbonnel C, Conversâ Domart R, Rigaudeau S, et al. Assessment of global longitudinal strain at lowâ dose anthracyclineâ based chemotherapy, for the prediction of subsequent cardiotoxicity. Eur Heart J Cardiovasc Imaging. 2017; 18 ( 4 ): 392 â 401.
dc.identifier.citedreferenceYoon GJ, Telli ML, Kao DP, Matsuda KY, Carlson RW, Witteles RM. Left ventricular dysfunction in patients receiving cardiotoxic cancer therapies are clinicians responding optimally? J Am Coll Cardiol. 2010; 56 ( 20 ): 1644 â 1650.
dc.identifier.citedreferenceKalam K, Otahal P, Marwick TH. Prognostic implications of global LV dysfunction: a systematic review and metaâ analysis of global longitudinal strain and ejection fraction. Heart. 2014; 100 ( 21 ): 1673 â 1680.
dc.identifier.citedreferenceAmundsen BH, Helleâ Valle T, Edvardsen T, et al. Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging. J Am Coll Cardiol. 2006; 47 ( 4 ): 789 â 793.
dc.identifier.citedreferencePlana JC, Galderisi M, Barac A, et al. Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2014; 27 ( 9 ): 911 â 939.
dc.identifier.citedreferenceEidem BW, McMahon CJ, Cohen RR, et al. Impact of cardiac growth on Doppler tissue imaging velocities: a study in healthy children. J Am Soc Echocardiogr. 2004; 17 ( 3 ): 212 â 221.
dc.identifier.citedreferenceHonda K, Takeshita K, Murotani K, et al. Assessment of left ventricular diastolic function during trastuzumab treatment in patients with HER2â positive breast cancer. Breast Cancer. 2017; 24 ( 2 ): 312 â 318.
dc.identifier.citedreferenceHarahsheh A, Aggarwal S, Pettersen MD, Lâ Ecuyer T. Diastolic function in anthracyclineâ treated children. Cardiol Young. 2015; 25 ( 6 ): 1130 â 1135.
dc.identifier.citedreferenceSivasubramanian N, Coker ML, Kurrelmeyer KM, et al. Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor. Circulation. 2001; 104 ( 7 ): 826 â 831.
dc.identifier.citedreferenceRoberts WC, Bodey GP, Wertlat PT. Wertlake PT. The heart in acute leukemia. A study of 420 autopsy cases. Am J Cardiol. 1968; 21 ( 3 ): 388 â 412.
dc.identifier.citedreferenceMertens AC, Liu Q, Neglia JP, et al. Causeâ specific late mortality among 5â year survivors of childhood cancer: the childhood cancer survivor study. J Natl Cancer Inst. 2008; 100 ( 19 ): 1368 â 1379.
dc.identifier.citedreferenceAmericanCancerSociety. Cancer Facts & Figures 2017. Available from: https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2017/cancer-facts-and-figures-2017.pdf
dc.identifier.citedreferenceLipshultz SE, Adams MJ, Colan SD, et al. Longâ term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions: a scientific statement from the American Heart Association. Circulation. 2013; 128 ( 17 ): 1927 â 1995.
dc.identifier.citedreferenceChildren’sOncologyGroup. Longâ Term Followâ up Guidelines for Survivors of Childhood, Adolescent and Young Adult Cancer 2013, October [Version 4.0]. Available from: http://www.survivorshipguidelines.org/pdf/LTFUGuidelines_40.pdf
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.