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Incentive and dopamine sensitization produced by intermittent but not long access cocaine self‐administration
dc.contributor.authorKawa, Alex B.
dc.contributor.authorValenta, Alec C.
dc.contributor.authorKennedy, Robert T.
dc.contributor.authorRobinson, Terry E.
dc.date.accessioned2019-10-30T15:31:33Z
dc.date.availableWITHHELD_11_MONTHS
dc.date.available2019-10-30T15:31:33Z
dc.date.issued2019-08
dc.identifier.citationKawa, Alex B.; Valenta, Alec C.; Kennedy, Robert T.; Robinson, Terry E. (2019). "Incentive and dopamine sensitization produced by intermittent but not long access cocaine self‐administration." European Journal of Neuroscience 50(4): 2663-2682.
dc.identifier.issn0953-816X
dc.identifier.issn1460-9568
dc.identifier.urihttps://hdl.handle.net/2027.42/151906
dc.description.abstractThe temporal pattern of drug use (pharmacokinetics) has a profound effect on the ability of self‐administered cocaine to produce addiction‐like behavior in rodents, and to change the brain. To further address this issue, we compared the effects of long access (LgA) cocaine self‐administration, which is widely used to model the transition to addiction, with intermittent access (IntA), which is thought to better reflect the pattern of drug use in humans, on the ability of a single, self‐administered injection of cocaine to increase dopamine (DA) overflow in the core of the nucleus accumbens (using in vivo microdialysis), and to produce addiction‐like behavior. IntA experience was more effective than LgA in producing addiction‐like behavior—a drug experience‐dependent increase in motivation for cocaine assessed using behavioral economic procedures, and cue‐induced reinstatement—despite much less total drug consumption. There were no group differences in basal levels of DA in dialysate [DA], but a single self‐administered IV injection of cocaine increased [DA] in the core of the nucleus accumbens to a greater extent in rats with prior IntA experience than those with LgA or limited access experience, and the latter two groups did not differ. Furthermore, high motivation for cocaine was associated with a high [DA] response. Thus, IntA, but not LgA, produced both incentive and DA sensitization. This is consistent with the notion that a hyper‐responsive dopaminergic system may contribute to the transition from casual patterns of drug use to the problematic patterns that define addiction.We compared the effects of long access cocaine self‐administration with intermittent access on the ability of self‐administered cocaine to increase dopamine overflow in the core of the nucleus accumbens and to produce addiction‐like behavior. Intermittent access (IntA) was more effective than long access (LgA) in producing addiction‐like behavior despite much less total drug consumption and cocaine increased dopamine to a greater extent in rats with prior IntA experience than those with LgA.
dc.publisherRoutledge
dc.publisherWiley Periodicals, Inc.
dc.subject.otherintermittent access
dc.subject.otheraddiction
dc.subject.othercocaine
dc.subject.otherdopamine
dc.subject.othersensitization
dc.titleIncentive and dopamine sensitization produced by intermittent but not long access cocaine self‐administration
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelNeurosciences
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/151906/1/ejn14418_am.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/151906/2/ejn14418.pdf
dc.identifier.doi10.1111/ejn.14418
dc.identifier.sourceEuropean Journal of Neuroscience
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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