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A case of immune reconstitution syndrome complicating progressive multifocal leukoencephalopathy after kidney transplant: Clinical, pathological, and radiographic features
dc.contributor.authorJackowiak, Eric
dc.contributor.authorShah, Nirav
dc.contributor.authorChen, Huiwen
dc.contributor.authorOjha, Ajitesh
dc.contributor.authorDoyle, John
dc.contributor.authorShepler, Anne
dc.contributor.authorBogdanovich, Tatiana
dc.contributor.authorSilveira, Fernanda P.
dc.contributor.authorHaidar, Ghady
dc.date.accessioned2019-11-12T16:21:42Z
dc.date.availableWITHHELD_12_MONTHS
dc.date.available2019-11-12T16:21:42Z
dc.date.issued2019-10
dc.identifier.citationJackowiak, Eric; Shah, Nirav; Chen, Huiwen; Ojha, Ajitesh; Doyle, John; Shepler, Anne; Bogdanovich, Tatiana; Silveira, Fernanda P.; Haidar, Ghady (2019). "A case of immune reconstitution syndrome complicating progressive multifocal leukoencephalopathy after kidney transplant: Clinical, pathological, and radiographic features." Transplant Infectious Disease 21(5): n/a-n/a.
dc.identifier.issn1398-2273
dc.identifier.issn1399-3062
dc.identifier.urihttps://hdl.handle.net/2027.42/151984
dc.description.abstractProgressive multifocal leukoencephalopathy (PML) is a life‐threatening central nervous system (CNS) disorder, most commonly described in patients infected with the human immunodeficiency virus (HIV). Limited data exist on its natural history and treatment in solid organ transplant (SOT) recipients. A complication of PML is the immune reconstitution inflammatory syndrome (IRIS), which develops after T cell reconstitution and can have severe consequences when it occurs in the CNS. While well described in HIV‐infected individuals, its clinical features, diagnosis, and treatment after SOT are largely unknown. We report a case of a kidney transplant recipient who was diagnosed with PML and developed significant worsening of her symptoms upon reduction of immunosuppression. Thallium SPECT showed avid uptake suggestive of lymphoma, but the diagnosis of PML‐IRIS was ultimately established by brain biopsy. She survived with nearly complete restoration of her functional status after a prolonged steroid taper.
dc.publisherWiley Periodicals, Inc.
dc.subject.othersolid organ transplant
dc.subject.otherrenal transplant
dc.subject.otherprogressive multifocal leukoencephalopathy (PML)
dc.subject.otherJC virus
dc.subject.otherimmune reconstitution inflammatory syndrome (IRIS)
dc.subject.otherthallium SPECT scan
dc.titleA case of immune reconstitution syndrome complicating progressive multifocal leukoencephalopathy after kidney transplant: Clinical, pathological, and radiographic features
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelMedicine (General)
dc.subject.hlbsecondlevelMicrobiology and Immunology
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/151984/1/tid13162.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/151984/2/tid13162_am.pdf
dc.identifier.doi10.1111/tid.13162
dc.identifier.sourceTransplant Infectious Disease
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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