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Lessons from a Minimal Genome: What Are the Essential Organizing Principles of a Cell Built from Scratch?
dc.contributor.authorTarnopol, Rebecca L.
dc.contributor.authorBowden, Sierra
dc.contributor.authorHinkle, Kevin
dc.contributor.authorBalakrishnan, Krithika
dc.contributor.authorNishii, Akira
dc.contributor.authorKaczmarek, Caleb J.
dc.contributor.authorPawloski, Tara
dc.contributor.authorVecchiarelli, Anthony G.
dc.date.accessioned2019-11-12T16:22:40Z
dc.date.availableWITHHELD_12_MONTHS
dc.date.available2019-11-12T16:22:40Z
dc.date.issued2019-10-15
dc.identifier.citationTarnopol, Rebecca L.; Bowden, Sierra; Hinkle, Kevin; Balakrishnan, Krithika; Nishii, Akira; Kaczmarek, Caleb J.; Pawloski, Tara; Vecchiarelli, Anthony G. (2019). "Lessons from a Minimal Genome: What Are the Essential Organizing Principles of a Cell Built from Scratch?." ChemBioChem 20(20): 2535-2545.
dc.identifier.issn1439-4227
dc.identifier.issn1439-7633
dc.identifier.urihttps://hdl.handle.net/2027.42/152011
dc.description.abstractOne of the primary challenges facing synthetic biology is reconstituting a living system from its component parts. A particularly difficult landmark is reconstituting a self‐organizing system that can undergo autonomous chromosome compaction, segregation, and cell division. Here, we discuss how the syn3.0 minimal genome can inform us of the core self‐organizing principles of a living cell and how these self‐organizing processes can be built from the bottom up. The review underscores the importance of fundamental biology in rebuilding life from its molecular constituents.A primary challenge in synthetic biology is reconstituting self‐organizing systems that can undergo autonomous chromosome compaction, segregation, and cell division. Here, we discuss how the syn3.0 minimal genome sheds light on the core self‐organizing principles of living cells and how these self‐organizing processes can be built from the bottom up.
dc.publisherSpringer
dc.publisherWiley Periodicals, Inc.
dc.subject.otherbottom-up biology
dc.subject.otherself-organization
dc.subject.othersynthetic biology
dc.subject.othersynthetic cell
dc.subject.otherminimal genome
dc.titleLessons from a Minimal Genome: What Are the Essential Organizing Principles of a Cell Built from Scratch?
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiological Chemistry
dc.subject.hlbtoplevelHealth Sciences
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/152011/1/cbic201900249.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/152011/2/cbic201900249_am.pdf
dc.identifier.doi10.1002/cbic.201900249
dc.identifier.sourceChemBioChem
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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