Synthesis of Oligoribonucleotides Using the 2‐Nitrobenzyloxymethyl Group for 2′‐Hydroxyl Protection
dc.contributor.author | Miller, Tod J. | |
dc.contributor.author | Schwartz, Miriam E. | |
dc.contributor.author | Gough, Geoffrey R. | |
dc.date.accessioned | 2020-01-13T15:02:53Z | |
dc.date.available | 2020-01-13T15:02:53Z | |
dc.date.issued | 2000-12 | |
dc.identifier.citation | Miller, Tod J.; Schwartz, Miriam E.; Gough, Geoffrey R. (2000). "Synthesis of Oligoribonucleotides Using the 2‐Nitrobenzyloxymethyl Group for 2′‐Hydroxyl Protection." Current Protocols in Nucleic Acid Chemistry 3(1): 3.7.1-3.7.8. | |
dc.identifier.issn | 1934-9270 | |
dc.identifier.issn | 1934-9289 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/152494 | |
dc.description.abstract | RNA can be rapidly synthesized using protected ribonucleoside phosphoramidite monomers that carry 2‐nitrobenzyloxymethyl groups on their 2‐hydroxyls. These protecting groups are removed from the oligoribonucleotide products by exposure to long‐wave UV light. | |
dc.publisher | Wiley Periodicals, Inc. | |
dc.title | Synthesis of Oligoribonucleotides Using the 2‐Nitrobenzyloxymethyl Group for 2′‐Hydroxyl Protection | |
dc.type | Article | |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Biological Chemistry | |
dc.subject.hlbsecondlevel | Chemical Engineering | |
dc.subject.hlbsecondlevel | Chemistry | |
dc.subject.hlbsecondlevel | Public Health | |
dc.subject.hlbtoplevel | Science | |
dc.subject.hlbtoplevel | Engineering | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/152494/1/cpnc0307.pdf | |
dc.identifier.doi | 10.1002/0471142700.nc0307s03 | |
dc.identifier.source | Current Protocols in Nucleic Acid Chemistry | |
dc.identifier.citedreference | Sinha, N.D., Biernat, J., McManus, J., and Köster, H. 1984. Polymer support oligonucleotide synthesis XVIII: Use of β‐cyanoethyl‐ N, N ‐dialkylamino‐/ N ‐morpholino phosphoramidite of deoxynucleosides for the synthesis of DNA fragments simplifying deprotection and isolation of the final product. Nucl. Acids Res. 12: 4539 ‐ 4557. | |
dc.identifier.citedreference | Vinayak, R., Colonna, F., Tsou, D., Mullah, B., Andrus, A., and Sproat, B. 1994. arge scale chemical synthesis and purification of RNA. Nucl. Acids Symp. Ser. 31: 165 – 166 | |
dc.identifier.citedreference | Schwartz, M.E., Breaker, R.R., Asteriadis, G.T., deBear, J.S., and Gough, G.R. 1992. Rapid synthesis of oligoribonucleotides using 2′‐ O ‐(2‐ nitrobenzyloxymethyl)‐protected monomers. Bio. Med. Chem. Lett. 2: 1019 ‐ 1024. | |
dc.identifier.citedreference | Schwartz, M.E., Breaker, R.R., Asteriadis, G.T., deBear, J.S., and Gough, G.R. 1992. Rapid synthesis of oligoribonucleotides using 2′‐ O ‐(2‐nitrobenzyloxymethyl)‐protected monomers. BioMed. Chem. Lett. 2: 1019 ‐ 1024. | |
dc.identifier.citedreference | Schwartz, M.E., Breaker, R.R., Asteriadis, G.T., and Gough, G.R. 1995. A universal adapter for chemical synthesis of DNA or RNA on any single type of solid support. Tetrahedron Lett. 36: 27 ‐ 30. | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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