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Stepwise Solid‐Phase Synthesis of Nucleopeptides
dc.contributor.authorGrandas, Anna
dc.contributor.authorMarchán, Vicente
dc.contributor.authorDebéthune, Laurent
dc.contributor.authorPedroso, Enrique
dc.date.accessioned2020-01-13T15:05:23Z
dc.date.available2020-01-13T15:05:23Z
dc.date.issued2004-03
dc.identifier.citationGrandas, Anna; Marchán, Vicente ; Debéthune, Laurent ; Pedroso, Enrique (2004). "Stepwise Solid‐Phase Synthesis of Nucleopeptides." Current Protocols in Nucleic Acid Chemistry 16(1): 4.22.1-4.22.54.
dc.identifier.issn1934-9270
dc.identifier.issn1934-9289
dc.identifier.urihttps://hdl.handle.net/2027.42/152587
dc.description.abstractPhosphodiester‐linked peptide‐oligonucleotide conjugates (nucleopeptides) are obtained by stepwise solid‐phase procedures. The peptide is first assembled on a suitably derivatized solid matrix and the oligonucleotide is subsequently elongated at the free hydroxyl group of the linking amino acid. Temporary acid‐labile and permanent base‐labile protecting groups are combined. Careful choice of the protection scheme is required to prevent and minimize side reactions that may degrade the target molecule.
dc.publisherWiley Periodicals, Inc.
dc.publisherAcademic Press
dc.subject.otherstepwise solid‐phase synthesis
dc.subject.otherpeptide‐oligonucleotide conjugates
dc.subject.otherprotecting groups
dc.subject.othernucleopeptides
dc.titleStepwise Solid‐Phase Synthesis of Nucleopeptides
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiological Chemistry
dc.subject.hlbsecondlevelChemical Engineering
dc.subject.hlbsecondlevelChemistry
dc.subject.hlbsecondlevelPublic Health
dc.subject.hlbtoplevelHealth Sciences
dc.subject.hlbtoplevelEngineering
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/152587/1/cpnc0422.pdf
dc.identifier.doi10.1002/0471142700.nc0422s16
dc.identifier.sourceCurrent Protocols in Nucleic Acid Chemistry
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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