Further evidence for supporting cell conversion in the damaged avian basilar papilla
dc.contributor.author | Adler, Henry J. | |
dc.contributor.author | Komeda, Mototane | |
dc.contributor.author | Raphael, Yehoash | |
dc.date.accessioned | 2020-01-13T15:07:12Z | |
dc.date.available | 2020-01-13T15:07:12Z | |
dc.date.issued | 1997-07 | |
dc.identifier.citation | Adler, Henry J.; Komeda, Mototane; Raphael, Yehoash (1997). "Further evidence for supporting cell conversion in the damaged avian basilar papilla." International Journal of Developmental Neuroscience 15(4-5): 375-385. | |
dc.identifier.issn | 0736-5748 | |
dc.identifier.issn | 1873-474X | |
dc.identifier.uri | https://hdl.handle.net/2027.42/152672 | |
dc.description.abstract | Two lines of evidence suggested that a process other than supporting cell divisions may give rise to new hair cells in the bird inner ear injured by either noise or ototoxic drugs. This process, supporting cell conversion, occurs when non‐dividing supporting cells transdifferentiate into hair cells. First, noise‐exposed chicks received zero, one or two daily i.p. injections of cytosine arabinoside (a DNA synthesis blocker), as well as two daily intraperitoneal injections of bromodeoxyuridine, for four days. Following sacrifice, the papillae were processed for bromodeoxyuridine immunocytochemistry. All the ears demonstrated dividing cells, but increasing the number of cytosine arabinoside injections decreased the number of labeled cells. Indeed, two cytosine arabinoside injections per day nearly completely blocked supporting cell divisions in the short hair cell region within the sound‐induced lesion. This suggested that unpaired, immature cells observed in a similar region with scanning electron microscopy, despite the presence of cytosine arabinoside, may have been products of supporting cell conversion. In the second experiment, birds were treated with gentamicin for three days. Upon sacrifice at 6 days post‐treatment, papillae were processed for light and transmission electron microscopy. Several unusual cells were observed with phenotypic features of both hair cells and supporting cells. The peculiar cells may be in a transition from the supporting cell phenotype to that of a hair cell. | |
dc.publisher | Wiley Periodicals, Inc. | |
dc.subject.other | mitosis | |
dc.subject.other | transdifferentiation | |
dc.subject.other | noise | |
dc.subject.other | ototoxicity | |
dc.subject.other | chick | |
dc.subject.other | supporting cell | |
dc.subject.other | hair cell | |
dc.title | Further evidence for supporting cell conversion in the damaged avian basilar papilla | |
dc.type | Article | |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Neurology and Neurosciences | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/152672/1/jdns0736574896000986.pdf | |
dc.identifier.doi | 10.1016/S0736-5748(96)00098-6 | |
dc.identifier.source | International Journal of Developmental Neuroscience | |
dc.identifier.citedreference | Y. Raphael, H.J. Adler, Y. Wang, P.A. Finger. Cell cycle of transdifferentiating supporting cells in the basilar papilla. Hear. Res. 80: 1994; 53 – 63 | |
dc.identifier.citedreference | E. Hashino, R.J. Salvi. Changing spatial patterns of DNA replication in the noise‐damaged chick cochlea. J. Cell Sci. 105: 1993; 23 – 31 | |
dc.identifier.citedreference | J. Brix, F.P. Fischer, G.A. Manley. The cuticular plate of the hair cell in relation to morphological gradients of the chicken basilar papilla. Hear. Res. 75: 1994; 244 – 256 | |
dc.identifier.citedreference | J.T. Corwin, D.A. Cotanche. Regeneration of sensory hair cells after acoustic trauma. Science. 240: 1988; 1772 – 1774 | |
dc.identifier.citedreference | D.A. Cotanche. Regeneration of hair cell stereociliary bundles in the chick cochlea following severe acoustic trauma. Hear. Res. 30: 1987; 181 – 196 | |
dc.identifier.citedreference | R.M. Cruz, P.R. Lambert, E.W Rubel. Light microscopic evidence of hair cell regeneration after gentamycin toxicity in chick cochlea. Arch. Otolaryngol. Head Neck Surg. 113: 1987; 1058 – 1062 | |
dc.identifier.citedreference | G. Eguchi, R. Kodama. Transdifferentiation. Curr. Opin. Cell Biol. 5: 1993; 1023 – 1028 | |
dc.identifier.citedreference | J.E. Finley, J.T. Corwin. Assessment of growth factor effects on dissociated hair cell progenitors cultured with a feeder layer. Abstr. Assoc. Res. Otolaryngol. 18: 1995; 84 | |
dc.identifier.citedreference | F.P. Fischer. Quantitative analysis of the innervation of the chicken basilar papilla. Hear. Res. 61: 1992; 167 – 178 | |
dc.identifier.citedreference | J.R. Hawkins, P.S. Steyger, N.R. Schuff, R.A. Baird. Calcium‐binding proteins may be early markers of non‐mitotically regenerating vestibular otolith hair cells. Abstr. Assoc. Res. Otolaryngol. 19: 1996; 28 | |
dc.identifier.citedreference | M.W. Kelley, X.‐M. Xu, M.E. Wagner, J.T. Corwin. The developing organ of Corti contains retinoic acid and forms supernumerary hair cells in response to exogenous retinoic acid in culture. Development. 119: 1993; 1041 – 1053 | |
dc.identifier.citedreference | L. Li, A. Forge. Morphological evidence for the possibility of direct supporting cell to hair cell conversion in the mature mammalian vestibular sensory epithelium. Abstr. Assoc. Res. Otolaryngol. 19: 1996; 26 | |
dc.identifier.citedreference | W.R. Lippe, E.W. Westbrook, B.M. Ryals. Hair cell regeneration in the chick cochlea following aminoglycoside toxicity. Hear. Res. 56: 1991; 203 – 210 | |
dc.identifier.citedreference | Y. Raphael. Evidence for supporting cell mitosis in response to acoustic trauma in the avian inner ear. J. Neurocytol. 21: 1992; 663 – 671 | |
dc.identifier.citedreference | Y. Raphael. Reorganization of the chick basilar papilla after acoustic trauma. J. Comp. Neurol. 330: 1993; 521 – 532 | |
dc.identifier.citedreference | Y. Raphael, J.M. Miller. Dual mechanisms for production of new hair cells in regenerating avian cochlea. Soc. Neurosci. Abstr. 17: 1991; 1214 | |
dc.identifier.citedreference | E. Hashino, E.K. TinHan, R.J. Salvi. Base‐to‐apex gradient of cell proliferation in the chick cochlea following kanamycin‐induced hair cell loss. Hear. Res. 88: 1995; 156 – 168 | |
dc.identifier.citedreference | D.W. Roberson, C.S. Kreig, E.W Rubel. Light microscopic evidence that direct transdifferentiatinn gives rise to new hair cells in regenerating avian auditory epithelium. Audit. Neurosci. 2: 1996; 195 – 205 | |
dc.identifier.citedreference | B.M. Ryals, E.W Rubel. Hair cell regeneration after acoustic trauma in adult Coturnix quail. Science. 240: 1988; 1774 – 1776 | |
dc.identifier.citedreference | B.M. Ryals, E.W. Westbrook. Hair cell regeneration in senescent quail. Hear. Res. 50: 1990; 87 – 96 | |
dc.identifier.citedreference | J.S. Stone, D.A. Cotanche. Identification of the timing of S phase and the patterns of cell proliferation during hair cell regeneration in the chick cochlea. J. Comp. Neurol. 341: 1994; 50 – 67 | |
dc.identifier.citedreference | K. Tanaka, C.A. Smith. Structure of the chicken’s inner ear: SEM and TEM study. Am. J. Anat. 153: 1978; 251 – 271 | |
dc.identifier.citedreference | T.T. Tsue, E.C. Oesterle, E.W Rubel. Diffusible factors regulate hair cell regeneration in the avian inner ear. Proc. nail Acad. Sci. U.S.A. 91: 1994; 1584 – 1588 | |
dc.identifier.citedreference | Y. Wang, Y. Raphael. Re‐innervation patterns of chick auditory sensory epithelium after acoustic overstimulation. Hear. Res. 97: 1996; 11 – 18 | |
dc.identifier.citedreference | M.E. Warchol, J.T. Corwin. Supporting cells in avian vestibular organs proliferate in serum‐free culture. Hear. Res. 71: 1993; 28 – 36 | |
dc.identifier.citedreference | X.‐M. Xu, J.T. Corwin. A protein with TGF α‐like immunoreactivity is expressed in the cochlea and may be up‐regulated during hair cell regeneration. Soc. Neurosci. Abstr. 19: 1993; 1579 | |
dc.identifier.citedreference | H.J. Adler. Tectorial membrane regeneration in the quail after multiple exposures to intense sound. Audiol. Neurootol. 1: 1996; 65 – 79 | |
dc.identifier.citedreference | H.J. Adler, Y. Raphael. New hair cells arise from supporting cell conversion in the acoustically damaged chick inner ear. Neurosci. Lett. 205: 1996; 17 – 20 | |
dc.identifier.citedreference | H.J. Adler, J. Phillips, Y. Raphael. Immunocytochemical evidence for supporting cell conversion in the acoustically damaged chick. Abstr. Assoc. Res. Otolaryngol. 19: 1996; 16 | |
dc.identifier.citedreference | R.A. Baird, S. Bales, C. Fiorillo, N.R. Schuff. In vivo and in vitro evidence for non‐mitotic hair cell regeneration in the bullfrog vestibular otolith organs. Assoc. Res. Otolaryng. Abstr. 18: 1995; 178 | |
dc.identifier.citedreference | V. Benda. Inhibitory activity of cytosine arabinoside on Marek’s disease virus. Fol. Biol. (Praha). 28: 1982; 311 – 315 | |
dc.identifier.citedreference | W.A. Beresford. Direct transdifferentiation: can cells change their phenotype without dividing? Cell Diff. Dev. 29: 1990; 81 – 93 | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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