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Overview of the Synthesis of Nucleoside Phosphates and Polyphosphates
dc.contributor.authorJohnson, David C.
dc.contributor.authorWidlanski, Theodore S.
dc.date.accessioned2020-01-13T15:09:18Z
dc.date.available2020-01-13T15:09:18Z
dc.date.issued2003-12
dc.identifier.citationJohnson, David C.; Widlanski, Theodore S. (2003). "Overview of the Synthesis of Nucleoside Phosphates and Polyphosphates." Current Protocols in Nucleic Acid Chemistry 15(1): 13.1.1-13.1.31.
dc.identifier.issn1934-9270
dc.identifier.issn1934-9289
dc.identifier.urihttps://hdl.handle.net/2027.42/152758
dc.description.abstractThis overview summarizes methodology used for the synthesis of nucleoside mono‐, di‐, and triphosphates. Selected techniques such as the Mitsunobu reaction, displacement reactions involving nucleoside 5′‐tosylates, “anion‐exchange” techniques, and phosphoramidite and phosphoramidate methodologies are highlighted. The chemistry of phosphorylation is detailed with respect to advantages and limitations under various conditions. Applicability of the methods toward the synthesis of analogs such as imidophosphates, phosphorothioates, and radiolabeled nucleotides is also addressed.
dc.publisherWiley‐Interscience
dc.subject.othernucleotide review
dc.subject.othernucleoside diphosphate
dc.subject.othernucleoside triphosphate
dc.subject.othernucleotide synthesis
dc.subject.otherphosphorothioate
dc.subject.otherimidophosphate
dc.subject.othernucleoside monophosphate
dc.titleOverview of the Synthesis of Nucleoside Phosphates and Polyphosphates
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiological Chemistry
dc.subject.hlbsecondlevelChemical Engineering
dc.subject.hlbsecondlevelChemistry
dc.subject.hlbsecondlevelPublic Health
dc.subject.hlbtoplevelEngineering
dc.subject.hlbtoplevelHealth Sciences
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/152758/1/cpnc1301.pdf
dc.identifier.doi10.1002/0471142700.nc1301s15
dc.identifier.sourceCurrent Protocols in Nucleic Acid Chemistry
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