An Integrated Plasmo‐Photoelectronic Nanostructure Biosensor Detects an Infection Biomarker Accompanying Cell Death in Neutrophils
dc.contributor.author | Park, Younggeun | |
dc.contributor.author | Ryu, Byunghoon | |
dc.contributor.author | Deng, Qiufang | |
dc.contributor.author | Pan, Baihong | |
dc.contributor.author | Song, Yujing | |
dc.contributor.author | Tian, Yuzi | |
dc.contributor.author | Alam, Hasan B. | |
dc.contributor.author | Li, Yongqing | |
dc.contributor.author | Liang, Xiaogan | |
dc.contributor.author | Kurabayashi, Katsuo | |
dc.date.accessioned | 2020-01-13T15:12:23Z | |
dc.date.available | WITHHELD_13_MONTHS | |
dc.date.available | 2020-01-13T15:12:23Z | |
dc.date.issued | 2020-01 | |
dc.identifier.citation | Park, Younggeun; Ryu, Byunghoon; Deng, Qiufang; Pan, Baihong; Song, Yujing; Tian, Yuzi; Alam, Hasan B.; Li, Yongqing; Liang, Xiaogan; Kurabayashi, Katsuo (2020). "An Integrated Plasmo‐Photoelectronic Nanostructure Biosensor Detects an Infection Biomarker Accompanying Cell Death in Neutrophils." Small 16(1): n/a-n/a. | |
dc.identifier.issn | 1613-6810 | |
dc.identifier.issn | 1613-6829 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/152883 | |
dc.description.abstract | Bacterial infections leading to sepsis are a major cause of deaths in the intensive care unit. Unfortunately, no effective methods are available to capture the early onset of infectious sepsis near the patient with both speed and sensitivity required for timely clinical treatment. To fill the gap, the authors develop a highly miniaturized (2.5 × 2.5 µm2) plasmo‐photoelectronic nanostructure device that detected citrullinated histone H3 (CitH3), a biomarker released to the blood circulatory system by neutrophils. Rapidly detecting CitH3 with high sensitivity has the great potential to prevent infections from developing life‐threatening septic shock. To this end, the author’s device incorporates structurally engineered arrayed hemispherical gold nanoparticles that are functionalized with high‐affinity antibodies. A nanoplasmonic resonance shift induces a photoconduction increase in a few‐layer molybdenum disulfide (MoS2) channel, and it provides the sensor signal. The device achieves label‐free detection of serum CitH3 with a 5‐log dynamic range from 10−4 to 101 ng mL and a sample‐to‐answer time <20 min. Using this biosensor, the authors longitudinally measure the dynamic CitH3 profiles of individual living mice in a sepsis model at high resolution over 12 hours. The developed biosensor may be poised for future translation to personalized management of systemic bacterial infections.The lack of an appropriate biosensing technology to detect the early onset of bacterial infections has prohibited timely clinical treatment of sepitc shock. This article presents a highly miniaturized plasmo‐photoelectronic device incorporating high‐affinity antibody‐conjugated hemispherical gold nanoparticles and a few‐layer molybdenum disulfide (MoS2) photoconductive channel to detect a blood biomarker released by neutrophils with high speed and sensitivity. | |
dc.publisher | Wiley Periodicals, Inc. | |
dc.subject.other | citrullinated histone H3 (CitH3) | |
dc.subject.other | localized surface plasmon resonance (LSPR) | |
dc.subject.other | molybdenum disulfide (MoS2) | |
dc.subject.other | optoelectronic biosensors | |
dc.subject.other | sepsis | |
dc.title | An Integrated Plasmo‐Photoelectronic Nanostructure Biosensor Detects an Infection Biomarker Accompanying Cell Death in Neutrophils | |
dc.type | Article | |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Physics | |
dc.subject.hlbsecondlevel | Materials Science and Engineering | |
dc.subject.hlbtoplevel | Science | |
dc.subject.hlbtoplevel | Engineering | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/152883/1/smll201905611-sup-0001-SuppMat.pdf | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/152883/2/smll201905611_am.pdf | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/152883/3/smll201905611.pdf | |
dc.identifier.doi | 10.1002/smll.201905611 | |
dc.identifier.source | Small | |
dc.identifier.citedreference | D. G. Remick, G. R. Bolgos, J. Siddiqui, J. Shin, J. A. Nemzek, Shock 2002, 17, 463. | |
dc.identifier.citedreference | J. C. Marshall, K. Reinhart, Crit. Care Med. 2009, 37, 2290. | |
dc.identifier.citedreference | E. Kolaczkowska, P. Kubes, Nat. Rev. Immunol. 2013, 13, 159. | |
dc.identifier.citedreference | I. Neeli, S. N. Khan, M. Radic, J. Immunol. 2008, 180, 1895. | |
dc.identifier.citedreference | Y. Li, B. Liu, E. Y. Fukudome, J. Lu, W. Chong, G. Jin, Z. Liu, G. C. Velmahos, M. Demoya, D. R. King, H. B. Alam, Surgery 2011, 150, 442. | |
dc.identifier.citedreference | B. Pan, H. B. Alam, W. Chong, J. Mobley, B. Liu, Q. Deng, Y. Liang, Y. Wang, E. Chen, T. Wang, M. Tewari, Y. Li, Sci. Rep. 2017, 7, 8972. | |
dc.identifier.citedreference | J. N. Anker, W. P. Hall, O. Lyandres, N. C. Shah, J. Zhao, R. P. Van Duyne, Nat. Mater. 2008, 7, 442. | |
dc.identifier.citedreference | B. Sepulveda, P. C. Angelome, L. M. Lechuga, L. M. Liz‐Marzan, Nano Today 2009, 4, 244. | |
dc.identifier.citedreference | X. H. Wang, T.‐W. Chang, G. Lin, M. R. Gartia, G. L. Liu, Anal. Chem. 2017, 89, 611. | |
dc.identifier.citedreference | S. M. Russell, R. de la Rica, Sens. Actuators, B 2018, 270, 327. | |
dc.identifier.citedreference | F. Yesilkoy, R. A. Terborg, J. Pello, A. A. Belushkin, Y. Jahani, V. Pruneri, H. Altug, Light: Sci. Appl. 2018, 7, 17152. | |
dc.identifier.citedreference | K. M. Mayer, J. H. Hafner, Chem. Rev. 2011, 111, 3828. | |
dc.identifier.citedreference | Y. Y. Wang, J. H. Zhou, J. H. Li, Small Methods 2017, 1, UNSP 1700197. | |
dc.identifier.citedreference | P. Y. Chen, M. T. Chung, W. McHugh, R. Nidetz, Y. W. Li, J. P. Fu, T. T. Cornell, T. P. Shanley, K. Kurabayashi, ACS Nano 2015, 9, 4173. | |
dc.identifier.citedreference | Y. Zhang, Y. Tang, Y.‐H. Hsieh, C.‐Y. Hsu, J. Xi, K.‐J. Lin, X. Jiang, Lab Chip 2012, 12, 3012. | |
dc.identifier.citedreference | Y. Park, B. Ryu, B. R. Oh, Y. Song, X. Liang, K. Kurabayashi, ACS Nano 2017, 11, 5697. | |
dc.identifier.citedreference | M. Chen, H. Nam, H. Rokni, S. Wi, J. S. Yoon, P. Chen, K. Kurabayashi, W. Lu, X. Liang, ACS Nano 2015, 9, 8773. | |
dc.identifier.citedreference | Q. Deng, B. Pan, H. Alam, Y. Liang, B. Liu, N. Mor‐Vaknin, X. Duan, A. M. Williams, Y. Tian, Z. Wu, J. Zhang, Y. Li, Front. Immunol. 2019, Under review. | |
dc.identifier.citedreference | J. Sebaugh, P. McCray, Pharmaceutical Statistics 2003, 2, 167. | |
dc.identifier.citedreference | S. J. Parker, P. E. Watkins, Br. J. Surg. 2001, 88, 22. | |
dc.identifier.citedreference | K. A. Wichterman, A. E. Baue, I. H. Chaudry, J. Surg. Res. 1980, 29, 189. | |
dc.identifier.citedreference | S. Q. Latifi, M. A. O’Riordan, A. D. Levine, Infect. Immun. 2002, 70, 4441. | |
dc.identifier.citedreference | K. Doi, A. Leelahavanichkul, P. S. Yuen, R. A. Star, J. Clin. Invest. 2009, 119, 2868. | |
dc.identifier.citedreference | S. Ruiz, F. Vardon‐Bounes, V. Merlet‐Dupuy, J.‐M. Conil, M. Buléon, O. Fourcade, I. Tack, V. Minville, Intensive Care Medicine Experimental 2016, 4, 22. | |
dc.identifier.citedreference | W. Xiao, M. N. Mindrinos, J. Seok, J. Cuschieri, A. G. Cuenca, H. Gao, D. L. Hayden, L. Hennessy, E. E. Moore, J. P. Minei, P. E. Bankey, J. L. Johnson, J. Sperry, A. B. Nathens, T. R. Billiar, M. A. West, B. H. Brownstein, P. H. Mason, H. V. Baker, C. C. Finnerty, M. G. Jeschke, M. C. Lopez, M. B. Klein, R. L. Gamelli, N. S. Gibran, B. Arnoldo, W. Xu, Y. Zhang, S. E. Calvano, G. P. McDonald‐Smith, D. A. Schoenfeld, J. D. Storey, J. P. Cobb, H. S. Warren, L. L. Moldawer, D. N. Herndon, S. F. Lowry, R. V. Maier, R. W. Davis, R. G. Tompkins, Inflammation, P. Host Response to Injury Large‐Scale Collaborative Research, J. Exp. Med. 2011, 208, 2581. | |
dc.identifier.citedreference | T. Zhao, B. Pan, H. B. Alam, B. Liu, R. T. Bronson, Q. Deng, E. Wu, Y. Li, Sci. Rep. 2016, 6, 36696. | |
dc.identifier.citedreference | P. Y. Chen, N. T. Huang, M. T. Chung, T. T. Cornell, K. Kurabayashi, Adv. Drug Delivery Rev. 2015, 95, 90. | |
dc.identifier.citedreference | R. Satija, A. K. Shalek, Trends Immunol. 2014, 35, 219. | |
dc.identifier.citedreference | J. W. Uhr, Science 1964, 145, 457. | |
dc.identifier.citedreference | H. Nam, S. Wi, H. Rokni, M. Chen, G. Priessnitz, W. Lu, X. Liang, ACS Nano 2013, 7, 5870. | |
dc.identifier.citedreference | T. Zhao, Y. Li, B. Liu, Z. Liu, W. Chong, X. Duan, D. K. Deperalta, G. C. Velmahos, H. B. Alam, Surgery 2013, 154, 206. | |
dc.identifier.citedreference | F. B. Mayr, S. Yende, D. C. Angus, Virulence 2014, 5, 4. | |
dc.identifier.citedreference | S. Laukemann, N. Kasper, P. Kulkarni, D. Steiner, A. C. Rast, A. Kutz, S. Felder, S. Haubitz, L. Faessler, A. Huber, C. A. Fux, B. Mueller, P. Schuetz, Medicine 2015, 94, e2264. | |
dc.identifier.citedreference | B. D. W. Group, Clin. Pharmacol. Ther. 2001, 69, 89. | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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