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A bloodâ based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial
dc.contributor.authorBowman, Gene L.
dc.contributor.authorDodge, Hiroko H.
dc.contributor.authorGuyonnet, Sophie
dc.contributor.authorZhou, Nina
dc.contributor.authorDonohue, Juliana
dc.contributor.authorBichsel, Aline
dc.contributor.authorSchmitt, Jeroen
dc.contributor.authorHooper, Claudie
dc.contributor.authorBartfai, Tamas
dc.contributor.authorAndrieu, Sandrine
dc.contributor.authorVellas, Bruno
dc.contributor.authorVellas, Bruno
dc.contributor.authorGuyonnet, Sophie
dc.contributor.authorCarrié, Isabelle
dc.contributor.authorBrigitte, Lauréane
dc.contributor.authorFaisant, Catherine
dc.contributor.authorLala, Françoise
dc.contributor.authorDelrieu, Julien
dc.contributor.authorVillars, Hélène
dc.contributor.authorCombrouze, Emeline
dc.contributor.authorBadufle, Carole
dc.contributor.authorZueras, Audrey
dc.contributor.authorAndrieu, Sandrine
dc.contributor.authorCantet, Christelle
dc.contributor.authorMorin, Christophe
dc.contributor.authorVan Kan, Gabor Abellan
dc.contributor.authorDupuy, Charlotte
dc.contributor.authorRolland, Yves
dc.contributor.authorCaillaud, Céline
dc.contributor.authorOusset, Pierre‐jean
dc.contributor.authorLala, Françoise
dc.date.accessioned2020-01-13T15:13:32Z
dc.date.available2020-03-03T21:29:36Zen
dc.date.issued2019
dc.identifier.citationBowman, Gene L.; Dodge, Hiroko H.; Guyonnet, Sophie; Zhou, Nina; Donohue, Juliana; Bichsel, Aline; Schmitt, Jeroen; Hooper, Claudie; Bartfai, Tamas; Andrieu, Sandrine; Vellas, Bruno; Vellas, Bruno; Guyonnet, Sophie; Carrié, Isabelle ; Brigitte, Lauréane ; Faisant, Catherine; Lala, Françoise ; Delrieu, Julien; Villars, Hélène ; Combrouze, Emeline; Badufle, Carole; Zueras, Audrey; Andrieu, Sandrine; Cantet, Christelle; Morin, Christophe; Van Kan, Gabor Abellan; Dupuy, Charlotte; Rolland, Yves; Caillaud, Céline ; Ousset, Pierre‐jean ; Lala, Françoise (2019). "A bloodâ based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial." Alzheimer’s & Dementia: Translational Research & Clinical Interventions 5(C): 953-963.
dc.identifier.issn2352-8737
dc.identifier.issn2352-8737
dc.identifier.urihttps://hdl.handle.net/2027.42/152935
dc.description.abstractIntroductionMultinutrient approaches may produce more robust effects on brain health through interactive qualities. We hypothesized that a bloodâ based nutritional risk index (NRI) including three biomarkers of diet quality can explain cognitive trajectories in the multidomain Alzheimer prevention trial (MAPT) over 3â years.MethodsThe NRI included erythrocyte nâ 3 polyunsaturated fatty acids (nâ 3 PUFA 22:6nâ 3 and 20:5nâ 3), serum 25â hydroxyvitamin D, and plasma homocysteine. The NRI scores reflect the number of nutritional risk factors (0â 3). The primary outcome in MAPT was a cognitive composite Z score within each participant that was fit with linear mixedâ effects models.ResultsEighty percent had at lease one nutritional risk factor for cognitive decline (NRI â ¥1: 573 of 712). Participants presenting without nutritional risk factors (NRI=0) exhibited cognitive enhancement (β = 0.03 standard units [SU]/y), whereas each NRI point increase corresponded to an incremental acceleration in rates of cognitive decline (NRIâ 1: β = â 0.04 SU/y, P = .03; NRIâ 2: β = â 0.08 SU/y, P < .0001; and NRIâ 3: β = â 0.11 SU/y, P = .0008).DiscussionIdentifying and addressing these wellâ established nutritional risk factors may reduce ageâ related cognitive decline in older adults; an observation that warrants further study.Highlightsâ ¢Multiâ nutrient approaches may produce more robust effects through interactive propertiesâ ¢Nutritional risk index can objectively quantify nutritionâ related cognitive changesâ ¢Optimum nutritional status associated with cognitive enhancement over 3â yearsâ ¢Suboptimum nutritional status associated with cognitive decline over 3â yearsâ ¢Optimizing this nutritional risk index may promote cognitive health in older adults
dc.publisherWiley Periodicals, Inc.
dc.publisherNational Academies Press (US)
dc.subject.otherElderly
dc.subject.otherCognitive decline
dc.subject.otherVitamin D
dc.subject.otherNutrient biomarkers
dc.subject.otherMetabolomics
dc.subject.otherBiomarkers of diet quality
dc.subject.otherOmegaâ 3 fatty acids
dc.subject.otherDHA
dc.subject.otherEPA
dc.subject.otherHomocysteine
dc.subject.otherAging
dc.titleA bloodâ based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelNeurology and Neurosciences
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/152935/1/trc2jtrci201911004.pdf
dc.identifier.doi10.1016/j.trci.2019.11.004
dc.identifier.sourceAlzheimer’s & Dementia: Translational Research & Clinical Interventions
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