Stroke and dementia risk: A systematic review and metaâ analysis
dc.contributor.author | Kuźma, Elżbieta | |
dc.contributor.author | Lourida, Ilianna | |
dc.contributor.author | Moore, Sarah F. | |
dc.contributor.author | Levine, Deborah A. | |
dc.contributor.author | Ukoumunne, Obioha C. | |
dc.contributor.author | Llewellyn, David J. | |
dc.date.accessioned | 2020-01-13T15:14:07Z | |
dc.date.available | 2020-01-13T15:14:07Z | |
dc.date.issued | 2018-11 | |
dc.identifier.citation | Kuźma, Elżbieta ; Lourida, Ilianna; Moore, Sarah F.; Levine, Deborah A.; Ukoumunne, Obioha C.; Llewellyn, David J. (2018). "Stroke and dementia risk: A systematic review and metaâ analysis." Alzheimer’s & Dementia 14(11): 1416-1426. | |
dc.identifier.issn | 1552-5260 | |
dc.identifier.issn | 1552-5279 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/152961 | |
dc.description.abstract | IntroductionStroke is an established risk factor for allâ cause dementia, though metaâ analyses are needed to quantify this risk.MethodsWe searched Medline, PsycINFO, and Embase for studies assessing prevalent or incident stroke versus a noâ stroke comparison group and the risk of allâ cause dementia. Random effects metaâ analysis was used to pool adjusted estimates across studies, and metaâ regression was used to investigate potential effect modifiers.ResultsWe identified 36 studies of prevalent stroke (1.9 million participants) and 12 studies of incident stroke (1.3 million participants). For prevalent stroke, the pooled hazard ratio for allâ cause dementia was 1.69 (95% confidence interval: 1.49â 1.92; PÂ <Â .00001; I2Â =Â 87%). For incident stroke, the pooled risk ratio was 2.18 (95% confidence interval: 1.90â 2.50; PÂ <Â .00001; I2Â =Â 88%). Study characteristics did not modify these associations, with the exception of sex which explained 50.2% of betweenâ study heterogeneity for prevalent stroke.DiscussionStroke is a strong, independent, and potentially modifiable risk factor for allâ cause dementia. | |
dc.publisher | Wiley Periodicals, Inc. | |
dc.publisher | University of York | |
dc.title | Stroke and dementia risk: A systematic review and metaâ analysis | |
dc.type | Article | |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Neurology and Neurosciences | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/152961/1/alzjjalz2018063061.pdf | |
dc.identifier.doi | 10.1016/j.jalz.2018.06.3061 | |
dc.identifier.source | Alzheimer’s & Dementia | |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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