A review of hippocampal activation in post‐traumatic stress disorder
dc.contributor.author | Joshi, Sonalee A. | |
dc.contributor.author | Duval, Elizabeth R. | |
dc.contributor.author | Kubat, Bradley | |
dc.contributor.author | Liberzon, Israel | |
dc.date.accessioned | 2020-01-13T15:15:49Z | |
dc.date.available | WITHHELD_13_MONTHS | |
dc.date.available | 2020-01-13T15:15:49Z | |
dc.date.issued | 2020-01 | |
dc.identifier.citation | Joshi, Sonalee A.; Duval, Elizabeth R.; Kubat, Bradley; Liberzon, Israel (2020). "A review of hippocampal activation in post‐traumatic stress disorder." Psychophysiology (1): n/a-n/a. | |
dc.identifier.issn | 0048-5772 | |
dc.identifier.issn | 1469-8986 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/153031 | |
dc.description.abstract | Post‐traumatic stress disorder (PTSD) is often characterized by deficits in memory encoding and retrieval and aberrant fear and extinction learning. The hippocampus plays a critical role in memory and contextual processing and has been implicated in intrinsic functional connectivity networks involved in self‐referential thought and memory‐related processes. This review focuses on hippocampal activation findings during memory and fear and extinction learning tasks, as well as resting state hippocampal connectivity in individuals with PTSD. A preponderance of functional neuroimaging studies to date, using memory, fear learning, and extinction tasks, report decreased or “controls comparable” hippocampal activation in individuals with PTSD, which is usually associated with poorer performance on the task imaged. Existing evidence thus raises the possibility that greater hippocampal recruitment in PTSD participants may be required for similar performance levels. Studies of resting state functional connectivity in PTSD predominantly report reduced within‐network connectivity in the default mode network (DMN), as well as greater coupling between the DMN and salience network (SN) via the hippocampus. Together, these findings suggest that deficient hippocampal activation in PTSD may be associated with poorer performance during memory, extinction recall, and fear renewal tasks. Furthermore, studies of resting state connectivity implicate the hippocampus in decreased within‐network DMN connectivity and greater coupling with SN regions characteristic of PTSD.The hippocampus plays a key role in memory, fear learning and extinction, and default mode network resting state connectivity, all processes which have known deficits in post‐traumatic stress disorder (PTSD). In this review, we examine recent fMRI studies on hippocampal function in PTSD and controls and identify critical areas for future research to explore. | |
dc.publisher | Author | |
dc.publisher | Wiley Periodicals, Inc. | |
dc.subject.other | extinction learning | |
dc.subject.other | PTSD | |
dc.subject.other | resting state | |
dc.subject.other | memory | |
dc.subject.other | hippocampus | |
dc.subject.other | fMRI | |
dc.subject.other | fear learning | |
dc.title | A review of hippocampal activation in post‐traumatic stress disorder | |
dc.type | Article | |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Psychology | |
dc.subject.hlbsecondlevel | Physiology | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/153031/1/psyp13357.pdf | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/153031/2/psyp13357_am.pdf | |
dc.identifier.doi | 10.1111/psyp.13357 | |
dc.identifier.source | Psychophysiology | |
dc.identifier.citedreference | Sapolsky, R. M. ( 2000 ). Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Archives of General Psychiatry, 57 ( 10 ), 925 – 935. https://doi.org/10.1001/archpsyc.57.10.925 | |
dc.identifier.citedreference | Pape, H.‐C., & Pare, D. ( 2010 ). Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear. Physiology Review, 90, 419 – 463. https://doi.org/10.1152/physrev.00037.2009 | |
dc.identifier.citedreference | Patel, R., Spreng, R. N., Shin, L. M., & Girard, T. A. ( 2012 ). Neurocircuitry models of posttraumatic stress disorder and beyond: A meta‐analysis of functional neuroimaging studies. Neuroscience and Biobehavioral Reviews, 36, 2130 – 2142. https://doi.org/10.1016/j.neubiorev.2012.06.003 | |
dc.identifier.citedreference | Patriat, R., Birn, R. M., Keding, T. J., & Herringa, R. J. ( 2016 ). Default‐mode network abnormalities in pediatric posttraumatic stress disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 55 ( 4 ), 319 – 327. https://doi.org/10.1016/j.jaac.2016.01.010 | |
dc.identifier.citedreference | Power, J. D, Cohen, A. L, Nelson, S. M, Wig, G. S, Barnes, K. A., Church, J. A., … Petersen, S. E. ( 2011 ). Functional network organization of the human brain. Neuron, 72 ( 4 ), 665 – 678. | |
dc.identifier.citedreference | Rabinak, C. A., MacNamara, A., Kennedy, A. E., Angstadt, M., Stein, M. B., Liberzon, I., & Phan, L. ( 2014 ). Focal and aberrant prefrontal engagement during emotion regulation in veterans with posttraumatic stress disorder. Depression and Anxiety, 31, 851 – 861. | |
dc.identifier.citedreference | Samuelson, K. W. ( 2011 ). Post‐traumatic stress disorder and declarative memory functioning: A review. Dialogues in Clinical Neuroscience, 13 ( 3 ), 346 – 351. | |
dc.identifier.citedreference | Scoville, W. B., & Milner, B. ( 1957 ). Loss of recent memory after bilateral hippocampal lesions. Journal of Neurology, Neurosurgery & Psychiatry, 20 ( 1 ), 11 – 21. https://doi.org/10.1136/jnnp.20.1.11 | |
dc.identifier.citedreference | Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Gary, H., Kenna, H., & Greicius, M. D. ( 2009 ). Dissociable intrinsic connectivity networks for salience processing and executive control. NIH Public Access, 27 ( 9 ), 2349 – 2356. https://doi.org/10.1523/JNEUROSCI.5587-06.2007 | |
dc.identifier.citedreference | Sharot, T., & Yonelinas, A. P. ( 2008 ). Differential time‐dependent effects of emotion on recollective experience and memory for contextual information. Cognition, 106 ( 1 ), 538 – 547. https://doi.org/10.1016/j.cognition.2007.03.002 | |
dc.identifier.citedreference | Sierra‐Mercado, D., Padilla‐Coreano, N., & Quirk, G. J. ( 2011 ). Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear. Neuropsychopharmacology, 36 ( 2 ), 529 – 538. https://doi.org/10.1038/npp.2010.184 | |
dc.identifier.citedreference | Shin, L. M., & Liberzon, I. ( 2010 ). The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology, 35 ( 1 ), 169 – 191. https://doi.org/10.1038/npp.2009.83 | |
dc.identifier.citedreference | Spielberg, J. M., McGlinchey, R. E., Milberg, W. P., & Salat, D. H. ( 2015 ). Brain network disturbance related to posttraumatic stress and traumatic brain injury in veterans. Biological Psychiatry, 78 ( 3 ), 210 – 216. https://doi.org/10.1016/j.biopsych.2015.02.013 | |
dc.identifier.citedreference | Sripada, R. K., Garfinkel, S. N., & Liberzon, I. ( 2013 ). Avoidant symptoms in PTSD predict fear circuit activation during multimodal fear extinction. Frontiers in Human Neuroscience, 7, https://doi.org/10.3389/fnhum.2013.00672 | |
dc.identifier.citedreference | Sripada, R. K., King, A. P., Welsh, R. C., Garfinkel, S. N., Wang, X., Sripada, C. S., & Liberzon, I. ( 2012 ). Neural dysregulation in posttraumatic stress disorder: Evidence for disrupted equilibrium between salience and default mode brain networks. Psychosomatic Medicine, 74 ( 9 ), 904 – 911. https://doi.org/10.1097/PSY.0b013e318273bf33 | |
dc.identifier.citedreference | St. Jacques, P. L., Botzung, A., Miles, A., & Rubin, D. C. ( 2011 ). Functional neuroimaging of emotionally intense autobiographical memories in post‐traumatic stress disorder. Journal of Psychiatric Research, 45 ( 5 ), 630 – 637. https://doi.org/10.1016/j.jpsychires.2010.10.011 | |
dc.identifier.citedreference | Steiger, F., Nees, F., Wicking, M., Lang, S., & Flor, H. ( 2015 ). Behavioral and central correlates of contextual fear learning and contextual modulation of cued fear in posttraumatic stress disorder. International Journal of Psychophysiology, 98 ( 3 ), 584 – 593. https://doi.org/10.1016/j.ijpsycho.2015.06.009 | |
dc.identifier.citedreference | Tamburrino, M. B., Chan, P., Prescott, M., Calabrese, J., Liberzon, I., Slembarski, R., … Galea, S. ( 2015 ). Baseline prevalence of Axis I diagnosis in the Ohio Army National Guard. Psychiatry Research, 226 ( 1 ), 142 – 148. https://doi.org/10.1016/j.psychres.2014.12.038 | |
dc.identifier.citedreference | Thomaes, K., Dorrepaal, E., Draijer, N. P. J., DeRuiter, M. B., Elzinga, B. M., VanBalkom, A. J., … Veltman, D. J. ( 2009 ). Increased activation of the left hippocampus region in complex PTSD during encoding and recognition of emotional words: A pilot study. Psychiatry Research, 171 ( 1 ), 44 – 53. | |
dc.identifier.citedreference | Thomaes, K., Dorrepaal, E., Draijer, N., deRuiter, M. B., Elzinga, B. M., Sjoerds, Z., … Veltman, D. J. ( 2013 ). Increased anterior cingulate cortex and hippocampus activation in complex PTSD during encoding of negative words. Social Cognitive and Affective Neuroscience, 8 ( 2 ), 190 – 200. https://doi.org/10.1093/scan/nsr084 | |
dc.identifier.citedreference | Thompson, W. W., Gottesman, I. I., & Zalewski, C. ( 2006 ). Reconciling disparate prevalence rates of PTSD in large samples of US male Vietnam veterans and their controls. BMC Psychiatry, 6, 19. https://doi.org/10.1186/1471-244X-6-19 | |
dc.identifier.citedreference | Vaidya, C. J., & Gordon, E. M. ( 2013 ). Phenotypic variability in resting‐state functional connectivity: Current status. Brain Connectivity, 3 ( 2 ), 99 – 120. https://doi.org/10.1089/brain.2012.0110 | |
dc.identifier.citedreference | Van Rooij, S. J. H., Kennis, M., Sjouwerman, R., van den Heuvel, M. P., Kahn, R. S., & Geuze, E. ( 2015 ). Smaller hippocampal volume as a vulnerability factor for the persistence of post‐traumatic stress disorder. Psychological Medicine, 45 ( 13 ), 2737 – 2746. https://doi.org/10.1017/S0033291715000707 | |
dc.identifier.citedreference | Vasterling, J. J., Duke, L. M., Brailey, K., Constans, J. I., Allain, A. N., & Sutker, P. B. ( 2002 ). Attention, learning, and memory performances and intellectual resources in Vietnam veterans: PTSD and no disorder comparisons. Neuropsychology, 16 ( 1 ), 5 – 14. https://doi.org/10.1037//0894-4105.16.1.5 | |
dc.identifier.citedreference | Werner, N. S., Meindl, T., Engel, R. R., Rosner, R., Riedel, M., Reiser, M., & Fast, K. ( 2009 ). Hippocampal function during associative learning in patients with posttraumatic stress disorder. Journal of Psychiatric Research, 43 ( 3 ), 309 – 318. https://doi.org/10.1016/j.jpsychires.2008.03.011 | |
dc.identifier.citedreference | Wicking, M., Steiger, F., Nees, F., Diener, S. J., Grimm, O., Ruttorf, M., … Flor, H. ( 2016 ). Deficient fear extinction memory in posttraumatic stress disorder. Neurobiology of Learning and Memory, 136, 116 – 126. https://doi.org/10.1016/j.nlm.2016.09.016 | |
dc.identifier.citedreference | Wotjak, C. T., & Pape, H.‐C. ( 2013 ). Neuronal circuits of fear memory and fear extinction. E‐Neuroforum, 19 ( 3 ), 47 – 56. https://doi.org/10.1007/s13295-013-0046-0 | |
dc.identifier.citedreference | Akiki, T. J., Averill, C. L., & Abdallah, C. G. ( 2017 ). A network‐based neurobiological model of PTSD: Evidence from structural and functional neuroimaging studies. Current Psychiatry Reports, 19 ( 11 ), 18. https://doi.org/10.1007/s11920-017-0840-4 | |
dc.identifier.citedreference | Allen, R. J. ( 2018 ). Classic and recent advances in understanding amnesia. F1000Research, 7, 331. https://doi.org/10.12688/f1000research.13737.1 | |
dc.identifier.citedreference | American Psychiatric Association ( 2013 ). Diagnostic and statistical manual of mental disorders ( 5th ed. ). Washington, DC: Author. | |
dc.identifier.citedreference | Bergstrom, H. C. ( 2016 ). The neurocircuitry of remote cued fear memory. Neuroscience and Biobehavioral Reviews, 71, 409 – 417. https://doi.org/10.1016/j.neubiorev.2016.09.028 | |
dc.identifier.citedreference | Berron, D., Schütze, H., Maass, A., Cardenas‐Blanco, A., Kuijf, H. J., Kumaran, D., & Düzel, E. ( 2018 ). Strong evidence for pattern separation in human dentate gyrus. Journal of Neuroscience, 36 ( 29 ), 7569 – 7579. https://doi.org/10.1523/JNEUROSCI.0518-16.2016 | |
dc.identifier.citedreference | Bremner, J. D. ( 2006 ). Traumatic stress: Effects on the brain. Dialogues in Clinical Neuroscience, 8 ( 4 ), 445 – 461. | |
dc.identifier.citedreference | Bremner, J. D., Staib, L. H., Kaloupek, D., Southwick, S. M., Soufer, R., & Charney, D. S. ( 1999 ). Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: A positron emission tomography study. Biological Psychiatry, 45, 806 – 816. | |
dc.identifier.citedreference | Brohawn, K. H., Offringa, R., Pfaff, D. L., Hughes, K. C., & Shin, L. M. ( 2010 ). The neural correlates of emotional memory in posttraumatic stress disorder. Biological Psychiatry, 68 ( 11 ), 1023 – 1030. https://doi.org/10.1016/j.biopsych.2010.07.018 | |
dc.identifier.citedreference | Brown, A., Addis, D. R., Romano, T., Marmar, C., Bryant, R., & Hirst, W. ( 2014 ). Episodic and semantic components of autobiographical memories and imagined future events in post‐traumatic stress disorder. Memory, 22, 595 – 604. | |
dc.identifier.citedreference | Brown, A. D., Root, J. C., Romano, T. A., Chang, L. J., Bryant, R. A., & Hirst, W. ( 2013 ). Overgeneralized autobiographical memory and future thinking in combat veterans with posttraumatic stress disorder. Journal of Behavior Therapy and Experimental Psychiatry, 44 ( 1 ), 129 – 134. https://doi.org/10.1016/j.jbtep.2011.11.004 | |
dc.identifier.citedreference | Carrión, V. G., Haas, B. W., Garrett, A., Song, S., & Reiss, A. L. ( 2010 ). Reduced hippocampal activity in youth with posttraumatic stress symptoms: An fMRI study. Journal of Pediatric Psychology, 35 ( 5 ), 559 – 569. https://doi.org/10.1093/jpepsy/jsp112 | |
dc.identifier.citedreference | Cisler, J. M., Bush, K., James, G. A., Smitherman, S., & Kilts, C. D. ( 2015 ). Decoding the traumatic memory among women with PTSD: Implications for neurocircuitry models of PTSD and real‐time fMRI neurofeedback. PLOS One, 10 ( 8 ), e0134717. https://doi.org/10.1371/journal.pone.0134717 | |
dc.identifier.citedreference | Chao, L., Weiner, M., & Neylan, T. ( 2013 ). Regional cerebral volumes in veterans with current versus remitted posttraumatic stress disorder. Psychiatry Research, 213 ( 3 ), 193 – 201. https://doi.org/10.1016/j.pscychresns.2013.03.002 | |
dc.identifier.citedreference | Childress, J. E., Mcdowell, E. J., Dalai, V. V., Bogale, S. R., Ramamurthy, C., Jawaid, A., … Schulz, P. E. ( 2013 ). Hippocampal Volumes in patients with chronic combat‐related posttraumatic stress disorder: A systematic review. Journal of Neuropsychiatry and Clinical Neurosciences, 25 ( 1 ), 12 – 25. https://doi.org/10.1176/appi.neuropsych.12010003 | |
dc.identifier.citedreference | Cohen, N. J., & Squire, L. R. ( 1980 ). Preserved learning and retention of a pattern‐analyzing skill in amnesia: Dissociation of knowing how and knowing that. Science, 210, 207 – 210. | |
dc.identifier.citedreference | Dere, E., Pause, B. M., & Pietrowsky, R. ( 2010 ). Emotion and episodic memory in neuropsychiatric disorders. Behavioral Brain Research, 215, 162 – 171. https://doi.org/10.1016/j.bbr.2010.03.017 | |
dc.identifier.citedreference | Duncan, K., Ketz, N., Inati, S. J., & Davachi, L. ( 2012 ). Evidence for area CA1 as a match/mismatch detector: A high‐resolution fMRI study of the human hippocampus. Hippocampus, 22 ( 3 ), 389 – 398. https://doi.org/10.1002/hipo.20933 | |
dc.identifier.citedreference | Duval, E., Javanbakht, A., & Liberzon, I. ( 2015 ). Neural circuits in anxiety and stress disorders: A focused review. Therapeutics and Clinical Risk Management, 11, 115 – 126. https://doi.org/10.2147/TCRM.S48528 | |
dc.identifier.citedreference | Ehlers, A., & Clark, D. M. ( 2000 ). A cognitive model of posttraumatic stress disorder. Behaviour Research and Therapy, 38, 319 – 345. https://doi.org/10.1016/S0005-7967(99)00123-0 | |
dc.identifier.citedreference | Eichenbaum, H. ( 2017 ). Prefrontal–hippocampal interactions in episodic memory. Nature Reviews Neuroscience, 18 ( 9 ), 547 – 558. https://doi.org/10.1038/nrn.2017.74 | |
dc.identifier.citedreference | Eichenbaum, H., & Cohen, N. J. ( 2014 ). Can we reconcile the declarative memory and spatial navigation views on hippocampal function? Neuron, 83 ( 4 ), 764 – 770. https://doi.org/10.1016/j.neuron.2014.07.032 | |
dc.identifier.citedreference | Fornito, A., & Bullmore, E. T. ( 2010 ). What can spontaneous fluctuations of the blood oxygenation‐level‐dependent signal tell us about psychiatric disorders? Current Opinion in Psychiatry, 23 ( 3 ), 239 – 249. https://doi.org/10.1097/yco.0b013e328337d78 | |
dc.identifier.citedreference | Fox, D., Snyder, A. Z., Barch, D. M., Gusnard, D. A., & Raichle, M. E. ( 2005 ). Transient BOLD responses at block transitions. NeuroImage, 28, 956 – 966. https://doi.org/10.1016/j.neuroimage.2005.06.025 | |
dc.identifier.citedreference | Frankland, P. W., & Bontempi, B. ( 2005 ). The organization of recent and remote memories. Nature Reviews Neuroscience, 6 ( 2 ), 119 – 130. https://doi.org/10.1038/nrn1607 | |
dc.identifier.citedreference | Garfinkel, S. N., Abelson, J. L., King, A. P., Sripada, R. K., Wang, X., Gaines, L. M., & Liberzon, I. ( 2014 ). Impaired contextual modulation of memories in PTSD: An fMRI and psychophysiological study of extinction retention and fear renewal. Journal of Neuroscience, 34 ( 40 ), 13435 – 13443. https://doi.org/10.1523/jneurosci.4287-13.2014 | |
dc.identifier.citedreference | Geuze, E., Vermetten, E., Ruf, M., de Kloet, C. S., & Westenberg, H. G. M. ( 2008 ). Neural correlates of associative learning and memory in veterans with posttraumatic stress disorder. Journal of Psychiatric Research, 42 ( 8 ), 659 – 669. https://doi.org/10.1016/j.jpsychires.2007.06.007 | |
dc.identifier.citedreference | Gilbert, P. E., Kesner, R. P., & Lee, I. ( 2001 ). Dissociating hippocampal subregions: Double dissociation between dentate gyrus and CA1. Hippocampus, 11 ( 6 ), 626 – 636. https://doi.org/10.1002/hipo.1077 | |
dc.identifier.citedreference | Gilbertson, M. W., Shenton, M. E., Ciszewski, A., Kasai, K., Lasko, N. B., Orr, S. P., & Pitman, R. K. ( 2002 ). Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nature Neuroscience, 5 ( 11 ), 1242 – 1247. https://doi.org/10.1038/nn958.Smaller | |
dc.identifier.citedreference | Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. ( 2003 ). Functional connectivity in the resting brain: A network analysis of the default mode hypothesis. Proceedings of the National Academy of Sciences of the United States of America, 100 ( 1 ), 253 – 258. https://doi.org/10.1073/pnas.0135058100 | |
dc.identifier.citedreference | Hayes, J. P., LaBar, K. S., McCarthy, G., Selgrade, E., Nasser, J., Dolcos, F., … Morey, R. A. ( 2011 ). Reduced hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat‐related PTSD. Journal of Psychiatric Research, 45 ( 5 ), 660 – 669. https://doi.org/10.1016/j.jpsychires.2010.10.007 | |
dc.identifier.citedreference | Hayes, J. P., Vanelzakker, M. B., & Shin, L. M. ( 2012 ). Emotion and cognition interactions in PTSD: A review of neurocognitive and neuroimaging studies. Frontiers in Integrative Neuroscience, 6 ( Oct ), 89. https://doi.org/10.3389/fnint.2012.00089 | |
dc.identifier.citedreference | Huijgen, J., & Samson, S. ( 2015 ). The hippocampus: A central node in a large‐scale brain network for memory. Revue Neurologique, 171 ( 3 ), 204 – 216. https://doi.org/10.1016/j.neurol.2015.01.557 | |
dc.identifier.citedreference | Janak, P. H., & Tye, K. M. ( 2015 ). From circuits to behaviour in the amygdala. Nature, 517 ( 7534 ), 284 – 292. https://doi.org/10.1038/nature14188 | |
dc.identifier.citedreference | Jin, C., Qi, R., Yin, Y., Hu, X., Duan, L., Xu, Q., … Li, L. ( 2014 ). Abnormalities in whole‐brain functional connectivity observed in treatment‐naive post‐traumatic stress disorder patients following an earthquake. Psychological Medicine, 44 ( 9 ), 1927 – 1936. https://doi.org/10.1017/S003329171300250X | |
dc.identifier.citedreference | Jovanovic, T., Kazama, A., Bachevalier, J., & Davis, M. ( 2012 ). Impaired safety signal learning may be a biomarker of PTSD. Neuropharmacology, 62 ( 2 ), 695 – 704. https://doi.org/10.1016/j.neuropharm.2011.02.023 | |
dc.identifier.citedreference | Kessler, R. C. ( 2000 ). Posttraumatic stress disorder: The burden to the individual and to society. Journal of Clinical Psychiatry, 61 ( Suppl 5 ), 4 – 12. | |
dc.identifier.citedreference | Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. ( 2005 ). Lifetime prevalence and age‐of‐onset distributions of DSM‐IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62, 593 – 602. https://doi.org/10.1001/archpsyc.62.6.593 | |
dc.identifier.citedreference | Labar, K. S., Gatenby, J., Gore, J. C., Ledoux, J. E., & Phelps, E. A. ( 1998 ). Human amygdala activation during conditioned fear acquisition and extinction: A mixed‐trial fMRI study. Neuron, 20 ( 5 ), 937 – 945. https://doi.org/10.1016/s0896-6273(00)80475-4 | |
dc.identifier.citedreference | Levy‐Gigi, E., Kéri, S., Myers, C. E., Lencovsky, Z., Sharvit‐Benbaji, H., Orr, S. P., … Gluck, M. A. ( 2012 ). Individuals with posttraumatic stress disorder show a selective deficit in generalization of associative learning. Neuropsychology, 26 ( 6 ), 758 – 767. https://doi.org/10.1037/a0029361 | |
dc.identifier.citedreference | Levy‐Gigi, E., Szabo, C., Richter‐Levin, G., & Kéri, S. ( 2014 ). Reduced hippocampal volume is associated with overgeneralization of negative context in individuals with PTSD. Neuropsychology, 29 ( 1 ), 151 – 161. https://doi.org/10.1037/neu0000131 | |
dc.identifier.citedreference | Liberzon, I., & Abelson, J. L. ( 2016 ). Context processing and the neurobiology of post‐traumatic stress disorder. Neuron, 92 ( 1 ), 14 – 30. https://doi.org/10.1016/j.neuron.2016.09.039 | |
dc.identifier.citedreference | Logue, M. W., van Rooij, S. J. H., Dennis, E. L., Davis, S. L., Hayes, J. P., Stevens, J. S., …, Morey, R. A. ( 2018 ). Smaller hippocampal volume in posttraumatic stress disorder: A multisite ENIGMA‐PGC study: Subcortical volumetry results from posttraumatic stress disorder consortia. Biological Psychiatry, 83, 244 – 253. https://doi.org/10.1016/j.biopsych.2017.09.006 | |
dc.identifier.citedreference | Lopresto, D., Schipper, P., & Homberg, J. R. ( 2016 ). Neural circuits and mechanisms involved in fear generalization: Implications for the pathophysiology and treatment of posttraumatic stress disorder. Neuroscience and Biobehavioral Reviews, 60, 31 – 42. https://doi.org/10.1016/j.neubiorev.2015.10.009 | |
dc.identifier.citedreference | Maren, S., Phan, K. L., & Liberzon, I. ( 2013 ). The contextual brain: Implications for fear conditioning, extinction and psychopathology. Nature Reviews Neuroscience, 14 ( 6 ), 417 – 428. https://doi.org/10.1038/nrn3492 | |
dc.identifier.citedreference | McCormick, C., Rosenthal, C. R., Miller, T. D., & Maguire, E. A. ( 2018 ). Mind‐wandering in people with hippocampal damage. Journal of Neuroscience, 38 ( 11 ), 2745 – 2754. https://doi.org/10.1523/jneurosci.1812-17.2018 | |
dc.identifier.citedreference | McEwen, B. S. ( 1999 ). Stress and hippocampal plasticity. Annual Review of Neuroscience, 22 ( 1 ), 105 – 122. https://doi.org/10.1146/annurev.neuro.22.1.105 | |
dc.identifier.citedreference | Meyer, T., Quaedflieg, C. W. E. M., Weijland, K., Schruers, K., Merckelbach, H., & Smeets, T. ( 2018 ). Frontal EEG asymmetry during symptom provocation predicts subjective responses to intrusions in survivors with and without PTSD. Psychophysiology, 55 ( 1 ), 88 – 108. https://doi.org/10.1111/psyp.12779 | |
dc.identifier.citedreference | Milad, M. R., Pitman, R. K., Ellis, C. B., Gold, A. L., Shin, L. M., Lasko, N. B., … Rauch, S. L. ( 2009 ). Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder. Biological Psychiatry, 66 ( 12 ), 1075 – 1082. https://doi.org/10.1016/j.biopsych.2009.06.026 | |
dc.identifier.citedreference | Milad, M. R., Wright, C. I., Orr, S. P., Pitman, R. K., Quirk, G. J., & Rauch, S. L. ( 2007 ). Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Biological Psychiatry, 62 ( 5 ), 446 – 454. https://doi.org/10.1016/j.biopsych.2006.10.011 | |
dc.identifier.citedreference | Miler, D. R., Hayes, S. M., Hayes, J. P., Spielberg, J. M., Lafleche, G., & Verfaellie, M. ( 2017 ). Default mode network subsystems are differentially disrupted in posttraumatic stress disorder. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2 ( 4 ), 363 – 371. https://doi.org/10.1016/j.bpsc.2016.12.006 | |
dc.identifier.citedreference | Mitra, A., & Raichle, M. E. ( 2016 ). How networks communicate: Propagation patterns in spontaneous brain activity. Philosophical Transactions of the Royal Society B: Biological Sciences, 371 ( 1705 ), 20150546. https://doi.org/10.1098/rstb.2015.0546 | |
dc.identifier.citedreference | Nadel, L., & Moscovitch, M. ( 1997 ). Memory consolidation, retrograde amnesia and the hippocampal complex. Current Opinions in Neurobiology, 7, 217 – 227. https://doi.org/10.1016/S0959-4388(97)80010-4 | |
dc.identifier.citedreference | Nakashiba, T., Cushman, J. D., Pelkey, K. A., Renaudineau, S., Buhl, D. L., McHugh, T. J., … Tonegawa, S. ( 2012 ). Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion. Cell, 149 ( 1 ), 188 – 201. https://doi.org/10.1016/j.cell.2012.01.046 | |
dc.identifier.citedreference | Nelson, M., & Tumpap, A. ( 2017 ). Posttraumatic stress disorder symptom severity is associated with left hippocampal volume reduction: A meta‐analytic study. CNS Spectrums, 22 ( 4 ), 363 – 372. https://doi.org/10.1017/S1092852916000833 | |
dc.identifier.citedreference | Niibori, Y., Yu, T.‐S., Epp, J. R., Akers, K. G., Josselyn, S. A., & Frankland, P. W. ( 2012 ). Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region. Nature Communications, 3, 1253. https://doi.org/10.1038/ncomms2261 | |
dc.identifier.citedreference | Opitz, B. ( 2014 ). Memory function and the hippocampus. Frontiers of Neurology and Neuroscience. The Hippocampus in Clinical Neuroscience, 34, 51 – 59. https://doi.org/10.1159/000356422 | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.