Phase 1 doseâ finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer
dc.contributor.author | Gulati, Shuchi | |
dc.contributor.author | Desai, Janki | |
dc.contributor.author | Palackdharry, Sarah M. | |
dc.contributor.author | Morris, John C. | |
dc.contributor.author | Zhu, Zheng | |
dc.contributor.author | Jandarov, Roman | |
dc.contributor.author | Riaz, Muhammad K. | |
dc.contributor.author | Takiar, Vinita | |
dc.contributor.author | Mierzwa, Michelle | |
dc.contributor.author | Gutkind, J. Silvio | |
dc.contributor.author | Molinolo, Alfredo | |
dc.contributor.author | Desai, Pankaj B. | |
dc.contributor.author | Sadraei, Nooshin Hashemi | |
dc.contributor.author | Wise‐draper, Trisha M. | |
dc.date.accessioned | 2020-01-13T15:19:59Z | |
dc.date.available | WITHHELD_13_MONTHS | |
dc.date.available | 2020-01-13T15:19:59Z | |
dc.date.issued | 2020-01-15 | |
dc.identifier.citation | Gulati, Shuchi; Desai, Janki; Palackdharry, Sarah M.; Morris, John C.; Zhu, Zheng; Jandarov, Roman; Riaz, Muhammad K.; Takiar, Vinita; Mierzwa, Michelle; Gutkind, J. Silvio; Molinolo, Alfredo; Desai, Pankaj B.; Sadraei, Nooshin Hashemi; Wise‐draper, Trisha M. (2020). "Phase 1 doseâ finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer." Cancer (2): 354-362. | |
dc.identifier.issn | 0008-543X | |
dc.identifier.issn | 1097-0142 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/153201 | |
dc.publisher | Wiley Periodicals, Inc. | |
dc.subject.other | metformin | |
dc.subject.other | clinical trial | |
dc.subject.other | head and neck cancer | |
dc.subject.other | phase 1 | |
dc.title | Phase 1 doseâ finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer | |
dc.type | Article | |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Public Health | |
dc.subject.hlbsecondlevel | Oncology and Hematology | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/153201/1/cncr32539.pdf | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/153201/2/cncr32539_am.pdf | |
dc.identifier.doi | 10.1002/cncr.32539 | |
dc.identifier.source | Cancer | |
dc.identifier.citedreference | Xiang AH, Trigo E, Martinez M, et al; RISE Collaborators. Impact of gastric banding versus metformin on βâ cell function in adults with impaired glucose tolerance or mild type 2 diabetes. Diabetes Care. 2018; 41: 2544 â 2551. | |
dc.identifier.citedreference | Surveillance, Epidemiology, and End Results. Common cancer sitesâ Cancer Stat Facts. Accessed June 10, 2019. https://seer.cancer.gov/statfacts/html/common.html | |
dc.identifier.citedreference | Burgy M, Leblanc J, Borel C. Any place left for induction chemotherapy for locally advanced head and neck squamous cell carcinoma? Anticancer Drugs. 2018; 29: 287 â 294. | |
dc.identifier.citedreference | Haddad RI, Posner M, Hitt R, et al. Induction chemotherapy in locally advanced squamous cell carcinoma of the head and neck: role, controversy, and future directions. Ann Oncol. 2018; 29: 1130 â 1140. doi: 10.1093/annonc/mdy102 | |
dc.identifier.citedreference | Ang KK, Zhang Q, Rosenthal DI, et al. Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522. J Clin Oncol. 2014; 32: 2940 â 2950. | |
dc.identifier.citedreference | Pignon JP, le Maitre A, Maillard E, Bourhis J; MACHâ NC Collaborative Group. Metaâ analysis of chemotherapy in head and neck cancer (MACHâ NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol. 2009; 92: 4 â 14. | |
dc.identifier.citedreference | Rego DF, Elias ST, Amato AA, Canto GD, Guerra EN. Antiâ tumor effects of metformin on head and neck carcinoma cell lines: a systematic review. Oncol Lett. 2017; 13: 554 â 566. | |
dc.identifier.citedreference | Chae YK, Arya A, Malecek MK, et al. Repurposing metformin for cancer treatment: current clinical studies. Oncotarget. 2016; 7: 40767 â 40780. | |
dc.identifier.citedreference | Yen YC, Lin C, Lin SW, Lin YS, Weng SF. Effect of metformin on the incidence of head and neck cancer in diabetics. Head Neck. 2015; 37: 1268 â 1273. | |
dc.identifier.citedreference | Sandulache VC, Hamblin JS, Skinner HD, Kubik MW, Myers JN, Zevallos JP. Association between metformin use and improved survival in patients with laryngeal squamous cell carcinoma. Head Neck. 2014; 36: 1039 â 1043. | |
dc.identifier.citedreference | Curry J, Johnson J, Tassone P, et al. Metformin effects on head and neck squamous carcinoma microenvironment: window of opportunity trial. Laryngoscope. 2017; 127: 1808 â 1815. | |
dc.identifier.citedreference | Rivadeneira DB, Delgoffe GM. Antitumor Tâ cell reconditioning: improving metabolic fitness for optimal cancer immunotherapy. Clin Cancer Res. 2018; 24: 2473 â 2481. | |
dc.identifier.citedreference | Scharping NE, Menk AV, Whetstone RD, Zeng X, Delgoffe GM. Efficacy of PDâ 1 blockade is potentiated by metforminâ induced reduction of tumor hypoxia. Cancer Immunol Res. 2017; 5: 9 â 16. | |
dc.identifier.citedreference | Najjar YG, Menk AV, Sander C, et al. Tumor cell oxidative metabolism as a barrier to PDâ 1 blockade immunotherapy in melanoma. JCI Insight. 2019; 4 ( 5 ). | |
dc.identifier.citedreference | Storozhuk Y, Hopmans SN, Sanli T, et al. Metformin inhibits growth and enhances radiation response of nonâ small cell lung cancer (NSCLC) through ATM and AMPK. Br J Cancer. 2013; 108: 2021 â 2032. | |
dc.identifier.citedreference | Ji Y, Wang SJ. Modified toxicity probability interval design: a safer and more reliable method than the 3 + 3 design for practical phase I trials. J Clin Oncol. 2013; 31: 1785 â 1791. | |
dc.identifier.citedreference | Yang W, Cai X, Wu H, Ji L. Associations between metformin use and vitamin B 12 levels, anemia, and neuropathy in patients with diabetes: a metaâ analysis. J Diabetes. 2019; 11: 729 â 743. | |
dc.identifier.citedreference | Graham GG, Punt J, Arora M, et al. Clinical pharmacokinetics of metformin. Clin Pharmacokinet. 2011; 50: 81 â 98. | |
dc.identifier.citedreference | Zazuli Z, Vijverberg S, Slob E, et al. Genetic variations and cisplatin nephrotoxicity: a systematic review. Front Pharmacol. 2018; 9: 1111. | |
dc.identifier.citedreference | Safirstein R, Miller P, Guttenplan JB. Uptake and metabolism of cisplatin by rat kidney. Kidney Int. 1984; 25: 753 â 758. | |
dc.identifier.citedreference | Dobyan DC, Levi J, Jacobs C, Kosek J, Weiner MW. Mechanism of cisâ platinum nephrotoxicity: II. Morphologic observations. J Pharmacol Exp Ther. 1980; 213: 551 â 556. | |
dc.identifier.citedreference | Rego DF, Pavan LM, Elias ST, De Luca Canto G, Guerra EN. Effects of metformin on head and neck cancer: a systematic review. Oral Oncol. 2015; 51: 416 â 422. | |
dc.identifier.citedreference | Skinner HD, Crane CH, Garrett CR, et al. Metformin use and improved response to therapy in rectal cancer. Cancer Med. 2013; 2: 99 â 107. | |
dc.identifier.citedreference | Trucco M, Barredo JC, Goldberg J, et al. A phase I window, dose escalating and safety trial of metformin in combination with induction chemotherapy in relapsed refractory acute lymphoblastic leukemia: metformin with induction chemotherapy of vincristine, dexamethasone, PEGâ asparaginase, and doxorubicin. Pediatr Blood Cancer. 2018; 65: e27224. doi: 10.1002/pbc.27224 | |
dc.identifier.citedreference | Morgillo F, Fasano M, Della Corte CM, et al. Results of the safety runâ in part of the METAL (METformin in Advanced Lung cancer) study: a multicentre, openâ label phase Iâ II study of metformin with erlotinib in secondâ line therapy of patients with stage IV nonâ smallâ cell lung cancer. ESMO Open. 2017; 2: e000132. | |
dc.identifier.citedreference | ClinicalTrials.gov. Chemotherapy and radiation therapy with or without metformin hydrochloride in treating patients with stage III nonâ small cell lung cancer. Accessed December 19, 2018. https://clinicaltrials.gov/ct2/show/NCT02186847 | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.