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Role of extracellular histones in the cardiomyopathy of sepsis
dc.contributor.authorKalbitz, Miriam
dc.contributor.authorGrailer, Jamison J.
dc.contributor.authorFattahi, Fatemeh
dc.contributor.authorJajou, Lawrence
dc.contributor.authorHerron, Todd J.
dc.contributor.authorCampbell, Katherine F.
dc.contributor.authorZetoune, Firas S.
dc.contributor.authorBosmann, Markus
dc.contributor.authorSarma, J. Vidya
dc.contributor.authorHuber‐lang, Markus
dc.contributor.authorGebhard, Florian
dc.contributor.authorLoaiza, Randall
dc.contributor.authorValdivia, Hector H.
dc.contributor.authorJalife, José
dc.contributor.authorRussell, Mark W.
dc.contributor.authorWard, Peter A.
dc.date.accessioned2020-03-17T18:27:36Z
dc.date.available2020-03-17T18:27:36Z
dc.date.issued2015-05
dc.identifier.citationKalbitz, Miriam; Grailer, Jamison J.; Fattahi, Fatemeh; Jajou, Lawrence; Herron, Todd J.; Campbell, Katherine F.; Zetoune, Firas S.; Bosmann, Markus; Sarma, J. Vidya; Huber‐lang, Markus ; Gebhard, Florian; Loaiza, Randall; Valdivia, Hector H.; Jalife, José ; Russell, Mark W.; Ward, Peter A. (2015). "Role of extracellular histones in the cardiomyopathy of sepsis." The FASEB Journal 29(5): 2185-2193.
dc.identifier.issn0892-6638
dc.identifier.issn1530-6860
dc.identifier.urihttps://hdl.handle.net/2027.42/154273
dc.description.abstractThe purpose of this study was to define the relationship in polymicrobial sepsis (in adult male C57BL/6 mice) between heart dysfunction and the appearance in plasma of extracellular histones. Procedures included induction of sepsis by cecal ligation and puncture and measurement of heart function using echocardiogram/Doppler parameters. We assessed the ability of histones to cause disequilibrium in the redox status and intracellular [Ca2+]i levels in cardiomyocytes (CMs) (from mice and rats). We also studied the ability of histones to disturb both functional and electrical responses of hearts perfused with histones. Main findings revealed that extracellular histones appearing in septic plasma required C5a receptors, polymorphonuclear leukocytes (PMNs), and the Nachtâ , LRRâ , and PYDâ domainsâ containing protein 3 (NLRP3) inflammasome. In vitro exposure of CMs to histones caused loss of homeostasis of the redox system and in [Ca2+]i, as wellas defects in mitochondrial function. Perfusion of hearts with histones caused electrical and functional dysfunction. Finally, in vivo neutralization of histones in septic mice markedly reduced the parameters of heart dysfunction. Histones caused dysfunction in hearts during polymicrobial sepsis. These events could be attenuated by histone neutralization, suggesting that histones may be targets in the setting of sepsis to reduce cardiac dysfunction.â Kalbitz, M., Grailer, J. J., Fattahi, F., Jajou, L., Herron, T. J., Campbell, K. F., Zetoune, F. S., Bosmann, M., Sarma, J. V., Huberâ Lang, M., Gebhard, F., Loaiza, R., Valdivia, H. H., Jalife, J., Russell, M. W., Ward, P. A. Role of extracellular histones in the cardiomyopathy of sepsis. FASEB J. 29, 2185â 2193 (2015). www.fasebj.org
dc.publisherFederation of American Societies for Experimental Biology
dc.publisherWiley Periodicals, Inc.
dc.subject.othercardiomyocytes
dc.subject.otherechocardiogram/Doppler
dc.subject.otherpolymicrobial sepsis
dc.subject.othercomplement
dc.subject.otherNLRP3 inflammasome
dc.titleRole of extracellular histones in the cardiomyopathy of sepsis
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/154273/1/fsb2fj14268730.pdf
dc.identifier.doi10.1096/fj.14-268730
dc.identifier.sourceThe FASEB Journal
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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