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Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk
dc.contributor.authorKivela, Riikka
dc.contributor.authorSilvennoinen, Mika
dc.contributor.authorLehti, Maarit
dc.contributor.authorRinnankoski‐tuikka, Rita
dc.contributor.authorPurhonen, Tatja
dc.contributor.authorKetola, Tarmo
dc.contributor.authorPullinen, Katri
dc.contributor.authorVuento, Meri
dc.contributor.authorMutanen, Niina
dc.contributor.authorSartor, Maureen A.
dc.contributor.authorReunanen, Hilkka
dc.contributor.authorKoch, Lauren G.
dc.contributor.authorBritton, Steven L.
dc.contributor.authorKainulainen, Heikki
dc.date.accessioned2020-03-17T18:27:46Z
dc.date.available2020-03-17T18:27:46Z
dc.date.issued2010-11
dc.identifier.citationKivela, Riikka; Silvennoinen, Mika; Lehti, Maarit; Rinnankoski‐tuikka, Rita ; Purhonen, Tatja; Ketola, Tarmo; Pullinen, Katri; Vuento, Meri; Mutanen, Niina; Sartor, Maureen A.; Reunanen, Hilkka; Koch, Lauren G.; Britton, Steven L.; Kainulainen, Heikki (2010). "Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk." The FASEB Journal 24(11): 4565-4574.
dc.identifier.issn0892-6638
dc.identifier.issn1530-6860
dc.identifier.urihttps://hdl.handle.net/2027.42/154281
dc.description.abstractA strong link exists between low aerobic exercise capacity and complex metabolic diseases. To probe this linkage, we utilized rat models of low and high intrinsic aerobic endurance running capacity that differ also in the risk for metabolic syndrome. We investigated in skeletal muscle geneâ phenotype relationships that connect aerobic endurance capacity with metabolic disease risk factors. The study compared 12 high capacity runners (HCRs) and 12 low capacity runners (LCRs) from generation 18 of selection that differed by 615% for maximal treadmill endurance running capacity. On average, LCRs were heavier and had increased blood glucose, insulin, and triglycerides compared with HCRs. HCRs were higher for resting metabolic rate, voluntary activity, serum high density lipoproteins, muscle capillarity, and mitochondrial area. Bioinformatic analysis of skeletal muscle gene expression data revealed that many genes upâ regulated in HCRs were related to oxidative energy metabolism. Seven mean mRNA expression centroids, including oxidative phosphorylation and fatty acid metabolism, correlated significantly with several exercise capacity and disease risk phenotypes. These expressionâ phenotype correlations, together with diminished skeletal muscle capillarity and mitochondrial area in LCR rats, support the general hypothesis that an inherited intrinsic aerobic capacity can underlie disease risks.â Kivelä, R., Silvennoinen, M., Lehti, M., Rinnankoskiâ Tuikka, R., Purhonen, T., Ketola, T., Pullinen, K., Vuento, M., Mutanen, N., Sartor, M. A., Reunanen, H., Koch, L. G., Britton, S. L., Kainulainen, H. Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk. FASEB J. 24, 4565â 4574 (2010). www.fasebj.org
dc.publisherWiley Periodicals, Inc.
dc.publisherFederation of American Societies for Experimental Biology
dc.subject.otherskeletal muscle
dc.subject.othercomplex metabolic disease
dc.subject.otheroxygen metabolism
dc.subject.othermitochondria
dc.subject.otherlipid metabolism
dc.titleGene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/154281/1/fsb2fj10157313.pdf
dc.identifier.doi10.1096/fj.10-157313
dc.identifier.sourceThe FASEB Journal
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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