Pharmacologic activation of estrogen receptor α increases mitochondrial function, energy expenditure, and brown adipose tissue
dc.contributor.author | Ponnusamy, Suriyan | |
dc.contributor.author | Tran, Quynh T. | |
dc.contributor.author | Harvey, Innocence | |
dc.contributor.author | Smallwood, Heather S. | |
dc.contributor.author | Thiyagarajan, Thirumagal | |
dc.contributor.author | Banerjee, Souvik | |
dc.contributor.author | Johnson, Daniel L. | |
dc.contributor.author | Dalton, James T. | |
dc.contributor.author | Sullivan, Ryan D. | |
dc.contributor.author | Miller, Duane D. | |
dc.contributor.author | Bridges, Dave | |
dc.contributor.author | Narayanan, Ramesh | |
dc.date.accessioned | 2020-03-17T18:27:52Z | |
dc.date.available | 2020-03-17T18:27:52Z | |
dc.date.issued | 2017-01 | |
dc.identifier.citation | Ponnusamy, Suriyan; Tran, Quynh T.; Harvey, Innocence; Smallwood, Heather S.; Thiyagarajan, Thirumagal; Banerjee, Souvik; Johnson, Daniel L.; Dalton, James T.; Sullivan, Ryan D.; Miller, Duane D.; Bridges, Dave; Narayanan, Ramesh (2017). "Pharmacologic activation of estrogen receptor α increases mitochondrial function, energy expenditure, and brown adipose tissue." The FASEB Journal 31(1): 266-281. | |
dc.identifier.issn | 0892-6638 | |
dc.identifier.issn | 1530-6860 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/154285 | |
dc.publisher | Wiley Periodicals, Inc. | |
dc.publisher | Federation of American Societies for Experimental Biology | |
dc.subject.other | exercise mimetic | |
dc.subject.other | mitochondria | |
dc.subject.other | oxygen consumption | |
dc.subject.other | obesity | |
dc.subject.other | metabolic diseases | |
dc.title | Pharmacologic activation of estrogen receptor α increases mitochondrial function, energy expenditure, and brown adipose tissue | |
dc.type | Article | |
dc.rights.robots | IndexNoFollow | |
dc.subject.hlbsecondlevel | Biology | |
dc.subject.hlbtoplevel | Science | |
dc.description.peerreviewed | Peer Reviewed | |
dc.description.bitstreamurl | https://deepblue.lib.umich.edu/bitstream/2027.42/154285/1/fsb2fj201600787rr.pdf | |
dc.identifier.doi | 10.1096/fj.201600787rr | |
dc.identifier.source | The FASEB Journal | |
dc.identifier.citedreference | Heinonen, S., Buzkova, J., Muniandy, M., Kaksonen, R., Ollikainen, M., Ismail, K., Hakkarainen, A., Lundbom, J., Lundbom, N., Vuolteenaho, K., Moilanen, E., Kaprio, J., Rissanen, A., Suomalainen, A., and Pietiléinen, K. H. ( 2015 ) Impaired mitochondrial biogenesis in adipose tissue in acquired obesity. Diabetes 64, 3135 – 3145 | |
dc.identifier.citedreference | Wu, Q., Tang, S. G., and Yuan, Z. M. ( 2015 ) Gremlin 2 inhibits adipocyte differentiation through activation of Wnt/b‐catenin signaling. Mol. Med. Rep. 12, 5891 – 5896 | |
dc.identifier.citedreference | Li, A., Leung, C. T., Peterson‐Yantorno, K., Stamer, W. D., Mitchell, C. H., and Civan, M. M. ( 2012 ) Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow. J. Cell. Physiol. 227, 172 – 182 | |
dc.identifier.citedreference | Guirguis, E., Hockman, S., Chung, Y. W., Ahmad, F., Gavrilova, O., Raghavachari, N., Yang, Y., Niu, G., Chen, X., Yu, Z. X., Liu, S., Degerman, E., and Manganiello, V. ( 2013 ) A role for phosphodiesterase 3B in acquisition of brown fat characteristics by white adipose tissue in male mice. Endocrinology 154, 3152 – 3167 | |
dc.identifier.citedreference | Rupérez, A. I., Olza, J., Gil‐Campos, M., Leis, R., Mesa, M.D., Tojo, R., Cañete, R., Gil, A., and Aguilera, C. M. ( 2014 ) Association of genetic polymorphisms for glutathione peroxidase genes with obesity in Spanish children. J. Nutrigenet. Nutrigenomics 7, 130 – 142 | |
dc.identifier.citedreference | Catalán, V., Gómez‐Ambrosi, J., Rodríguez, A., Ramírez, B., Silva, C., Rotellar, F., Gil, M. J., Cienfuegos, J. A., Salvador, J., and Frühbeck, G. ( 2009 ) Increased adipose tissue expression of lipocalin‐2 in obesity is related to inflammation and matrix metalloproteinase‐2 and metalloproteinase‐9 activities in humans. J. Mol. Med. (Berl.) 87, 803 – 813 | |
dc.identifier.citedreference | Fried, S. K., and Greenberg, A. S. ( 2012 ) Lipocalin 2: a “sexy” adipokine that regulates 17b‐estradiol and obesity. Endocrinology 153, 1582 – 1584 | |
dc.identifier.citedreference | Gustafson, B., Hammarstedt, A., Hedjazifar, S., Hoffmann, J. M., Svensson, P. A., Grimsby, J., Rondinone, C., and Smith, U. ( 2015 ) BMP4 and BMP antagonists regulate human white and beige adipogenesis. Diabetes 64, 1670 – 1681 | |
dc.identifier.citedreference | Jones, B. J., and Bloom, S. R. ( 2015 ) The new era of drug therapy for obesity: the evidence and the expectations. Drugs 75, 935 – 945 | |
dc.identifier.citedreference | Schmid, G. M., Converset, V., Walter, N., Sennitt, M. V., Leung, K. Y., Byers, H., Ward, M., Hochstrasser, D. F., Cawthorne, M. A., and Sanchez, J. C. ( 2004 ) Effect of high‐fat diet on the expression of proteins in muscle, adipose tissues, and liver of C57BL/6 mice. Proteomics 4, 2270 – 2282 | |
dc.identifier.citedreference | Costanzo‐Garvey, D. L., Pfluger, P. T., Dougherty, M. K., Stock, J. L., Boehm, M., Chaika, O., Fernandez, M. R., Fisher, K., Kortum, R. L., Hong, E. G., Jun, J. Y., Ko, H. J., Schreiner, A., Volle, D. J., Treece, T., Swift, A. L., Winer, M., Chen, D., Wu, M., Leon, L. R., Shaw, A. S., McNeish, J., Kim, J. K., Morrison, D. K., Tschöp, M. H., and Lewis, R. E. ( 2009 ) KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. Cell Metab. 10, 366 – 378 | |
dc.identifier.citedreference | Qian, S. W., Tang, Y., Li, X., Liu, Y., Zhang, Y. Y., Huang, H. Y., Xue, R. D., Yu, H. Y., Guo, L., Gao, H. D., Liu, Y., Sun, X., Li, Y. M., Jia, W.P., and Tang, Q. Q. ( 2013 ) BMP4‐mediated brown fat‐like changes in white adipose tissue alter glucose and energy homeostasis. Proc. Natl. Acad. Sci. USA 110, e798–e807 | |
dc.identifier.citedreference | Bag, S., Ramaiah, S., and Anbarasu, A. ( 2015 ) fabp4 is central to eight obesity associated genes: a functional gene network‐based polymorphic study. J. Theor. Biol. 364, 344 – 354 | |
dc.identifier.citedreference | Rosen, E. D., Hsu, C. H., Wang, X., Sakai, S., Freeman, M.W., Gonzalez, F. J., and Spiegelman, B. M. ( 2002 ) C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev. 16, 22 – 26 | |
dc.identifier.citedreference | Lean, M. E., and James, W. P. ( 1983 ) Uncoupling protein in human brown adipose tissue mitochondria. Isolation and detection by specific antiserum. FEBS Lett. 163, 235 – 240 | |
dc.identifier.citedreference | Ji, L., Gupta, M., and Feldman, B. J. ( 2016 ) Vitamin D regulates fatty acid composition in subcutaneous adipose tissue through Elovl3. Endocrinology 1, 91 – 97 | |
dc.identifier.citedreference | Chrysovergis, K., Wang, X., Kosak, J., Lee, S. H., Kim, J. S., Foley, J.F., Travlos, G., Singh, S., Baek, S. J., and Eling, T. E. ( 2014 ) NAG‐1/GDF15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism. Int. J. Obes. 38, 1555 – 1564 | |
dc.identifier.citedreference | Fink, T., and Zachar, V. ( 2011 ) Adipogenic differentiation of human mesenchymal stem cells. Methods Mol. Biol. 698, 243 – 251 | |
dc.identifier.citedreference | Chan, D. C. ( 2006 ) Mitochondria: dynamic organelles in disease, aging, and development. Cell 125, 1241 – 1252 | |
dc.identifier.citedreference | Choi, S., and Snider, A. J. ( 2015 ) Sphingolipids in high fat diet and obesity‐related diseases. Mediators Inflamm. 2015, 520618 | |
dc.identifier.citedreference | Kurek, K., Mikłosz, A., Łukaszuk, B., Chabowski, A., Górski, J., and Żendzian‐Piotrowska, M. ( 2015 ) Inhibition of ceramide de novo synthesis ameliorates diet induced skeletal muscles insulin resistance. J. Diabetes Res. 2015, 154762 | |
dc.identifier.citedreference | Matula, K., Collie‐Duguid, E., Murray, G., Parikh, K., Grabsch, H., Tan, P., Lalwani, S., Garau, R., Ong, Y., Bain, G., Smith, A. D., Urquhart, G., Bielawski, J., Finnegan, M., and Petty, R. ( 2015 ) Regulation of cellular sphingosine‐1‐phosphate by sphingosine kinase 1 and sphingosine‐1‐phopshate lyase determines chemotherapy resistance in gastroesophageal cancer. BMC Cancer 15, 762 | |
dc.identifier.citedreference | Pérez, S. E., Chen, E. Y., and Mufson, E. J. ( 2003 ) Distribution of estrogen receptor alpha and beta immunoreactive profiles in the postnatal rat brain. Brain Res. Dev. Brain Res. 145, 117 – 139 | |
dc.identifier.citedreference | Rebouças, E. C., Leal, S., and Sá, S. I. ( 2016 ) Regulation of NPY and a‐MSH expression by estradiol in the arcuate nucleus of Wistar female rats: a stereological study. Neurol. Res. 38, 740 – 747 | |
dc.identifier.citedreference | Peng, X. R., Gennemark, P., O’Mahony, G., and Bartesaghi, S. ( 2015 ) Unlock the thermogenic potential of adipose tissue: pharmacological modulation and implications for treatment of diabetes and obesity. Front. Endocrinol. (Lausanne) 6, 174 | |
dc.identifier.citedreference | Miao, Y., Wu, W., Dai, Y., Maneix, L., Huang, B., Warner, M., and Gustafsson, J.A. ( 2015 ) Liver Xreceptor b controls thyroid hormone feedback in the brain and regulates browning of subcutaneous white adipose tissue. Proc. Natl. Acad. Sci. USA 112, 14006–14011 | |
dc.identifier.citedreference | Fang, S., Suh, J. M., Reilly, S. M., Yu, E., Osborn, O., Lackey, D., Yoshihara, E., Perino, A., Jacinto, S., Lukasheva, Y., Atkins, A. R., Khvat, A., Schnabl, B., Yu, R. T., Brenner, D. A., Coulter, S., Liddle, C., Schoonjans, K., Olefsky, J. M., Saltiel, A. R., Downes, M., and Evans, R. M. ( 2015 ) Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat. Med. 21, 159 – 165 | |
dc.identifier.citedreference | Pedram, A., Razandi, M., Korach, K. S., Narayanan, R., Dalton, J. T., and Levin, E. R. ( 2013 ) ERb selective agonist inhibits angiotensininduced cardiovascular pathology in female mice. Endocrinology 154, 4352 – 4364 | |
dc.identifier.citedreference | Pedram, A., Razandi, M., Narayanan, R., Dalton, J. T., McKinsey, T. A., and Levin, E. R. ( 2013 ) Estrogen regulates histone deacetylases to prevent cardiac hypertrophy. Mol. Biol. Cell 24, 3805 – 3818 | |
dc.identifier.citedreference | Pedram, A., Razandi, M., O’Mahony, F., Lubahn, D., and Levin, E. R. ( 2010 ) Estrogen receptor‐beta prevents cardiac fibrosis. Mol. Endocrinol. 24, 2152 – 2165 | |
dc.identifier.citedreference | Wang, Q., Zhang, M., Xu, M., Gu, W., Xi, Y., Qi, L., Li, B., and Wang, W. ( 2015 ) Brown adipose tissue activation is inversely related to central obesity and metabolic parameters in adult human. PLoS One 10, e0123795 | |
dc.identifier.citedreference | Tharp, K. M., and Stahl, A. ( 2015 ) Bioengineering beige adipose tissue therapeutics. Front. Endocrinol. (Lausanne) 6, 164 | |
dc.identifier.citedreference | Flegal, K. M., Carroll, M. D., Kit, B. K., and Ogden, C. L. ( 2012 ) Prevalence of obesity and trends in the distribution of body mass index among U.S. adults, 1999–2010. JAMA 307, 491 – 497 | |
dc.identifier.citedreference | Ogden, C. L., Carroll, M.D., Kit, B. K., and Flegal, K. M. ( 2014 ) Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA 311, 806 – 814 | |
dc.identifier.citedreference | Shrager, B., Jibara, G. A., Tabrizian, P., Roayaie, S., and Ward, S. C. ( 2012 ) Resection of nonalcoholic steatohepatitis‐associated hepatocellular carcinoma: a Western experience. Int. J. Surg. Oncol. 2012, 915128 | |
dc.identifier.citedreference | Jensen, M.D., Ryan, D. H., Apovian, C. M., Ard, J.D., Comuzzie, A.G., Donato, K.A., Hu, F.B., Hubbard, V. S., Jakicic, J.M., Kushner, R. F., Loria, C. M., Millen, B. E., Nonas, C. A., Pi‐Sunyer, F. X., Stevens, J., Stevens, V. J., Wadden, T. A., Wolfe, B. M., and Yanovski, S. Z.; American College of Cardiology/American Heart Association Task Force on Practice Guidelines; Obesity Society. ( 2014 ) 2013 AHA/ ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Obesity Society. J. Am. Coll. Cardiol. 63 ( 25 Pt B ), 2985 – 3023. Erratum in: J. Am. Coll. Cardiol. 2014;63(25 Pt B), 3029–3030 | |
dc.identifier.citedreference | Bray, G. A., and Gray, D. S. ( 1988 ) Obesity. Part I‐pathogenesis. West. J. Med. 149, 429 – 441 | |
dc.identifier.citedreference | Madden, N. ( 2015 ) Obesity weighing down U.S. economy, study finds [electronic version]. WashingtonTimes. Retrieved September 19, 2016, from http://www.washingtontimes.com/news/2015/may/13/obesity‐weighing‐down‐us‐economy‐study‐finds/ | |
dc.identifier.citedreference | Cunningham, J. W., and Wiviott, S. D. ( 2014 ) Modern obesity pharmacotherapy: weighing cardiovascular risk and benefit. Clin. Cardiol. 37, 693 – 699 | |
dc.identifier.citedreference | Patel, D. ( 2015 ) Pharmacotherapy for the management of obesity. Metabolism 64, 1376 – 1385 | |
dc.identifier.citedreference | Smith, S.R., Weissman, N.J., Anderson, C.M., Sanchez, M., Chuang, E., Stubbe, S., Bays, H., Shanahan, W. R., and Behavioral, M.; Behavioral Modification and Lorcaserin for Overweight and Obesity Management (BLOOM) Study Group. ( 2010 ) Multicenter, placebo‐controlled trial of lorcaserin for weight management. N. Engl. J. Med. 363, 245 – 256 | |
dc.identifier.citedreference | Mercken, E. M., Carboneau, B. A., Krzysik‐Walker, S. M., and de Cabo, R. ( 2012 ) Of mice and men: the benefits of caloric restriction, exercise, and mimetics. Ageing Res. Rev. 11, 390 – 398 | |
dc.identifier.citedreference | Lee, Y. K., and Cowan, C. A. ( 2013 ) White to brite adipocyte transition and back again. Nat. Cell Biol. 15, 568 – 569 | |
dc.identifier.citedreference | Moisan, A., Lee, Y. K., Zhang, J. D., Hudak, C. S., Meyer, C. A., Prummer, M., Zoffmann, S., Truong, H. H., Ebeling, M., Kiialainen, A., Gérard, R., Xia, F., Schinzel, R. T., Amrein, K. E., and Cowan, C. A. ( 2015 ) White‐to‐brown metabolic conversion of human adipocytes by JAK inhibition. Nat. Cell Biol. 17, 57 – 67 | |
dc.identifier.citedreference | Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y. K., Palma, M.J., Calhoun, S., Georgiadi, A., Chen, M. H., Ramachandran, V. S., Larson, M. G., Bouchard, C., Rankinen, T., Souza, A. L., Clish, C. B., Wang, T. J., Estall, J. L., Soukas, A. A., Cowan, C. A., Spiegelman, B. M., and Gerszten, R. E. ( 2014 ) b‐Aminoisobutyric acid induces browning of white fat and hepatic b‐oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 19, 96 – 108 | |
dc.identifier.citedreference | Fan, W., Atkins, A.R., Yu, R.T., Downes, M., and Evans, R.M. ( 2013 ) Road to exercise mimetics: targeting nuclear receptors in skeletal muscle. J. Mol. Endocrinol. 51, T87 – T100 | |
dc.identifier.citedreference | Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y. X., Banayo, E., Mihaylova, M.M., Nelson, M.C., Zou, Y., Juguilon, H., Kang, H., Shaw, R. J., and Evans, R. M. ( 2008 ) AMPK and PPARdelta agonists are exercise mimetics. Cell 134, 405 – 415 | |
dc.identifier.citedreference | Bhardwaj, P., Du, B., Zhou, X. K., Sue, E., Giri, D., Harbus, M.D., Falcone, D. J., Hudis, C. A., Subbaramaiah, K., and Dannenberg, A. J. ( 2015 ) Estrogen protects against obesity‐induced mammary gland inflammation in mice. Cancer Prev. Res. (Phila.) 8, 751 – 759 | |
dc.identifier.citedreference | Luglio, H. F. ( 2014 ) Estrogen and body weight regulation in women: the role of estrogen receptor alpha (ER‐a) on adipocyte lipolysis. Acta Med. Indones. 46, 333 – 338 | |
dc.identifier.citedreference | Davis, K.E., Carstens, E.J., Irani, B. G., Gent, L. M., Hahner, L. M., and Clegg, D. J. ( 2014 ) Sexually dimorphic role of G protein‐coupled estrogen receptor (GPER) in modulating energy homeostasis. Horm. Behav. 66, 196 – 207 | |
dc.identifier.citedreference | Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F.C., Palmer, E. L., Tseng, Y. H., Doria, A., Kolodny, G. M., and Kahn, C. R. ( 2009 ) Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 360, 1509 – 1517 | |
dc.identifier.citedreference | Wang, Y., Shoemaker, R., Thatcher, S. E., Batifoulier‐Yiannikouris, F., English, V. L., and Cassis, L. A. ( 2015 ) Administration of 17b‐estradiol to ovariectomized obese female mice reverses obesity‐hypertension through an ACE2‐dependent mechanism. Am. J. Physiol. Endocrinol. Metab. 308, e1066–e1075 | |
dc.identifier.citedreference | Salamanca, S., and Uphouse, L. ( 1992 ) Estradiol modulation of the hyperphagia induced by the 5‐HT1A agonist, 8‐OH‐DPAT. Pharmacol. Biochem. Behav. 43, 953 – 955 | |
dc.identifier.citedreference | Musatov, S., Chen, W., Pfaff, D. W., Mobbs, C.V., Yang, X.J., Clegg, D. J., Kaplitt, M. G., and Ogawa, S. ( 2007 ) Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Proc. Natl. Acad. Sci. USA 104, 2501 – 2506 | |
dc.identifier.citedreference | Santollo, J., and Eckel, L. A. ( 2013 ) Oestradiol decreases melanin‐concentrating hormone (MCH) and MCH receptor expression in the hypothalamus of female rats. J. Neuroendocrinol. 25, 570 – 579 | |
dc.identifier.citedreference | Rivera, H. M., Santollo, J., Nikonova, L. V., and Eckel, L. A. ( 2012 ) Estradiol increases the anorexia associated with increased 5‐HT(2C) receptor activation in ovariectomized rats. Physiol. Behav. 105, 188 – 194 | |
dc.identifier.citedreference | Dierks‐Ventling, C., and Bieri‐Bonniot, F. ( 1977 ) Stimulation of RNA polymerase I and II activities by 17 beta‐estradiol receptor on chick liver chromatin. Nucleic Acids Res. 4, 381 – 395 | |
dc.identifier.citedreference | Kuiper, G. G., Enmark, E., Pelto‐Huikko, M., Nilsson, S., and Gustafsson, J. A. ( 1996 ) Cloning of a novel receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. USA 93, 5925 – 5930 | |
dc.identifier.citedreference | Revankar, C. M., Cimino, D. F., Sklar, L. A., Arterburn, J. B., and Prossnitz, E. R. ( 2005 ) A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307, 1625 – 1630 | |
dc.identifier.citedreference | Yoshii, T., Yamada, M., Minami, T., Tsunoda, T., Sasaki, M., Kondo, Y., Satoh, S., and Terauchi, Y. ( 2015 ) The effects of bazedoxifene on bone, glucose, and lipid metabolism in postmenopausal women with type 2 diabetes: an exploratory pilot study. J. Clin. Med. Res. 7, 762 – 769 | |
dc.identifier.citedreference | Meyer, M. R., Fredette, N. C., Howard, T. A., Hu, C., Ramesh, C., Daniel, C., Amann, K., Arterburn, J. B., Barton, M., and Prossnitz, E. R. ( 2014 ) G protein‐coupled estrogen receptor protects from atherosclerosis. Sci. Rep. 4, 7564 | |
dc.identifier.citedreference | Yepuru, M., Eswaraka, J., Kearbey, J. D., Barrett, C. M., Raghow, S., Veverka, K. A., Miller, D. D., Dalton, J. T., and Narayanan, R. ( 2010 ) Estrogen receptor‐beta‐selective ligands alleviate high‐fat diet‐ and ovariectomy‐induced obesity in mice. J. Biol. Chem. 285, 31292–31303 | |
dc.identifier.citedreference | Jungbauer, A., and Medjakovic, S. ( 2014 ) Phytoestrogens and the metabolic syndrome. J. SteroidBiochem. Mol. Biol. 139, 277 – 289 | |
dc.identifier.citedreference | Weigt, C., Hertrampf, T., Kluxen, F. M., Flenker, U., Hülsemann, F., Fritzemeier, K. H., and Diel, P. ( 2013 ) Molecular effects of ER alpha‐and beta‐selective agonists on regulation of energy homeostasis in obese female Wistar rats. Mol. Cell. Endocrinol. 377, 147 – 158 | |
dc.identifier.citedreference | Heine, P. A., Taylor, J. A., Iwamoto, G. A., Lubahn, D. B., and Cooke, P. S. ( 2000 ) Increased adipose tissue in male and female estrogen receptor‐alpha knockout mice. Proc. Natl. Acad. Sci. USA 97, 12729–12734 | |
dc.identifier.citedreference | Cooke, P. S., Heine, P. A., Taylor, J. A., and Lubahn, D. B. ( 2001 ) The role of estrogen and estrogen receptor‐alpha in male adipose tissue. Mol. Cell. Endocrinol. 178, 147 – 154 | |
dc.identifier.citedreference | Ivanova, T., and Beyer, C. ( 2000 ) Ontogenetic expression and sex differences of aromatase and estrogen receptor‐alpha/beta mRNA in the mouse hippocampus. Cell Tissue Res. 300, 231 – 237 | |
dc.identifier.citedreference | Karolczak, M., and Beyer, C. ( 1998 ) Developmental sex differences in estrogen receptor‐beta mRNA expression in the mouse hypothalamus/preoptic region. Neuroendocrinology 68, 229 – 234 | |
dc.identifier.citedreference | Chiang, S. H., Chang, L., and Saltiel, A. R. ( 2006 ) TC10 and insulin‐stimulated glucose transport. Methods Enzymol. 406, 701 – 714 | |
dc.identifier.citedreference | Foryst‐Ludwig, A., Clemenz, M., Hohmann, S., Hartge, M., Sprang, C., Frost, N., Krikov, M., Bhanot, S., Barros, R., Morani, A., Gustafsson, J. A., Unger, T., and Kintscher, U. ( 2008 ) Metabolic actionsof estrogen receptor beta (ERbeta) are mediated by a negative cross‐talk with PPARgamma. PLoS Genet. 4, e1000108 | |
dc.identifier.citedreference | Burke, L. K., Doslikova, B., D’Agostino, G., Garfield, A. S., Farooq, G., Burdakov, D., Low, M. J., Rubinstein, M., Evans, M. L., Billups, B., and Heisler, L. K. ( 2014 ) 5‐HT obesity medication efficacy via POMC activation is maintained during aging. Endocrinology 155, 3732 – 3738 | |
dc.identifier.citedreference | Thomsen, W. J., Grottick, A. J., Menzaghi, F., Reyes‐Saldana, H., Espitia, S., Yuskin, D., Whelan, K., Martin, M., Morgan, M., Chen, W., Al‐Shamma, H., Smith, B., Chalmers, D., and Behan, D. ( 2008 ) Lorcaserin, a novel selective human 5‐hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization. J. Pharmacol. Exp. Ther. 325, 577 – 587 | |
dc.identifier.citedreference | Smith, B.M., Smith, J. M., Tsai, J. H., Schultz, J. A., Gilson, C.A., Estrada, S. A., Chen, R. R., Park, D. M., Prieto, E. B., Gallardo, C. S., Sengupta, D., Dosa, P. I., Covel, J. A., Ren, A., Webb, R. R., Beeley, N. R., Martin, M., Morgan, M., Espitia, S., Saldana, H. R., Bjenning, C., Whelan, K.T., Grottick, A.J., Menzaghi, F., and Thomsen, W. J. ( 2008 ) Discovery and structure‐activity relationship of (1R)‐8‐chloro‐2,3,4,5tetrahydro‐1‐methyl‐1H‐3‐benzazepine (lorcaserin), a selective serotonin 5‐HT2C receptor agonist for the treatment of obesity. J. Med. Chem. 51, 305 – 313 | |
dc.identifier.citedreference | An, S., Han, J. I., Kim, M. J., Park, J. S., Han, J. M., Baek, N. I., Chung, H. G., Choi, M. S., Lee, K. T., and Jeong, T. S. ( 2010 ) Ethanolic extracts of Brassica campestris spp. rapa roots prevent high‐fat diet‐ induced obesity via beta(3) ‐adrenergic regulation of white adipocyte lipolytic activity. J. Med. Food 13, 406 – 414 | |
dc.identifier.citedreference | Ingalls, A. M., Dickie, M. M., and Snell, G. D. ( 1950 ) Obese, a new mutation in the house mouse. J. Hered. 41, 317 – 318 | |
dc.identifier.citedreference | Wu, J., Boström, P., Sparks, L. M., Ye, L., Choi, J. H., Giang, A. H., Khandekar, M., Virtanen, K. A., Nuutila, P., Schaart, G., Huang, K., Tu, H., Van Marken Lichtenbelt, W. D., Hoeks, J., Enerbéck, S., Schrauwen, P., and Spiegelman, B. M. ( 2012 ) Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150, 366 – 376 | |
dc.identifier.citedreference | Harms, M., and Seale, P. ( 2013 ) Brown and beige fat: development, function and therapeutic potential. Nat. Med. 19, 1252 – 1263 | |
dc.identifier.citedreference | Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.J., Enerbéck, S., and Nuutila, P. ( 2009 ) Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 360, 1518 – 1525 | |
dc.identifier.citedreference | Wang, W., Kissig, M., Rajakumari, S., Huang, L., Lim, H. W., Won, K. J., and Seale, P. ( 2014 ) Ebf2 is a selective marker of brown and beige adipogenic precursor cells. Proc. Natl. Acad. Sci. USA 111, 14466–14471 | |
dc.identifier.citedreference | Lidell, M. E., Seifert, E. L., Westergren, R., Heglind, M., Gowing, A., Sukonina, V., Arani, Z., Itkonen, P., Wallin, S., Westberg, F., Fernandez‐Rodriguez, J., Laakso, M., Nilsson, T., Peng, X. R., Harper, M. E., and Enerbéck, S. ( 2011 ) The adipocyte‐expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function. Diabetes 60, 427 – 435 | |
dc.identifier.citedreference | Hao, Q., Yadav, R., Basse, A. L., Petersen, S., Sonne, S.B., Rasmussen, S., Zhu, Q., Lu, Z., Wang, J., Audouze, K., Gupta, R., Madsen, L., Kristiansen, K., and Hansen, J.B. ( 2015 ) Transcriptomeprofiling of brown adipose tissue during cold exposure reveals extensive regulation of glucose metabolism. Am. J. Physiol. Endocrinol. Metab. 308, e380–e392 | |
dc.identifier.citedreference | Gnad, T., Scheibler, S., von Kügelgen, I., Scheele, C., Kilióde, A., Hoffmann, L. S., Reverte‐Salisa, L., Horn, P., Mutlu, S., El‐Tayeb, A., Kranz, M., Deuther‐Conrad, W., Brust, P., Lidell, M. E., Betz, M. J., Enerbéck, S., Schrader, J., Yegutkin, G. G., Müller, C. E., and Pfeifer, A. ( 2014 ) Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors. Nature 516, 395 – 399 | |
dc.identifier.citedreference | Liang, J., Xu, Z.X., Ding, Z., Lu, Y., Yu, Q., Werle, K. D., Zhou, G., Park, Y. Y., Peng, G., Gambello, M. J., and Mills, G. B. ( 2015 ) Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance. Nat. Commun. 6, 7926 | |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.