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Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long‐lived mutant mice
dc.contributor.authorPanici, Jacob A.
dc.contributor.authorHarper, James M.
dc.contributor.authorMiller, Richard A.
dc.contributor.authorBartke, Andrzej
dc.contributor.authorSpong, Adam
dc.contributor.authorMasternak, Michal M.
dc.date.accessioned2020-03-17T18:28:47Z
dc.date.available2020-03-17T18:28:47Z
dc.date.issued2010-12
dc.identifier.citationPanici, Jacob A.; Harper, James M.; Miller, Richard A.; Bartke, Andrzej; Spong, Adam; Masternak, Michal M. (2010). "Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long‐lived mutant mice." The FASEB Journal 24(12): 5073-5079.
dc.identifier.issn0892-6638
dc.identifier.issn1530-6860
dc.identifier.urihttps://hdl.handle.net/2027.42/154320
dc.description.abstractHypopituitary Ames dwarf mice were injected either with growth hormone (GH) or thyroxine for a 6‐wk period to see whether this intervention would reverse their long life span or the resistance of their cells to lethal stresses. Ames dwarf mice survived 987 ± 24 d (median), longer than nonmutant control mice (664±48), but GH‐injected dwarf mice did not differ from controls (707 ± 9). Fibroblast cells from Ames dwarf mice were more resistant to cadmium than cells from nonmutant controls (LD50 values of 9.98±1.7 and 3.9±0.8, respectively), but GH injections into Ames dwarf mice restored the normal level of cadmium resistance (LD50 = 5.8±0.9). Similar restoration of normal resistance was observed for fibroblasts exposed to paraquat, methyl methanesulfonate, and rotenone (P<0.05 in each case for contrast of GH‐treated vs. untreated dwarf mice;P<0.05 for dwarf vs. nonmutant control mice.) T4 injections into Ames dwarf mice, in contrast, did not restore normal life span. We conclude that the remarkable life‐span extension of Ames dwarf mice, and the stress resistance of cells from these mice, depends on low levels of GH exposure in juvenile and very young adult mice.—Panici, J. A., Harper, J. M., Miller, R. A., Bartke, A., Spong, A., Masternak, M. M. Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long‐lived mutant mice. FASEB J. 24, 5073–5079 (2010). www.fasebj.org
dc.publisherWiley Periodicals, Inc.
dc.subject.otherAmes dwarf
dc.subject.otherstress resistance
dc.subject.otheraging
dc.titleEarly life growth hormone treatment shortens longevity and decreases cellular stress resistance in long‐lived mutant mice
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/154320/1/fsb2fj10163253.pdf
dc.identifier.doi10.1096/fj.10.163253
dc.identifier.sourceThe FASEB Journal
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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