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Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst
dc.contributor.authorObrosova, Irina G.
dc.contributor.authorMabley, Jon G.
dc.contributor.authorZsengellér, Zsuzsanna
dc.contributor.authorCharniauskaya, Tamara
dc.contributor.authorAbatan, Omorodola I.
dc.contributor.authorGroves, John T.
dc.contributor.authorSzabó, Csaba
dc.date.accessioned2020-03-17T18:28:54Z
dc.date.available2020-03-17T18:28:54Z
dc.date.issued2005-03
dc.identifier.citationObrosova, Irina G.; Mabley, Jon G.; Zsengellér, Zsuzsanna ; Charniauskaya, Tamara; Abatan, Omorodola I.; Groves, John T.; Szabó, Csaba (2005). "Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst." The FASEB Journal 19(3): 1-21.
dc.identifier.issn0892-6638
dc.identifier.issn1530-6860
dc.identifier.urihttps://hdl.handle.net/2027.42/154323
dc.description.abstractNitrosative stress, that is, enhanced peroxynitrite formation, has been documented in both experimental and clinical diabetic neuropathy (DN), but its pathogenetic role remains unexplored. This study evaluated the role for nitrosative stress in two animal models of type 1 diabetes: streptozotocin‐diabetic mice and diabetic NOD mice. Control (C) and streptozotocin‐diabetic (D) mice were treated with and without the potent peroxynitrite decomposition catalyst FP15 (5 mg kg−1 d−1) for 1 wk after 8 wk without treatment. Sciatic nerve nitrotyrosine (a marker of peroxynitrite‐induced injury) and poly(ADP‐ribose) immunoreactivities were present in D and absent in C and D+FP15. FP15 treatment corrected sciatic motor and hind‐limb digital sensory nerve conduction deficits and sciatic nerve energy state in D, without affecting those variables in C. Nerve glucose and sorbitol pathway intermediate concentrations were similarly elevated in D and D+FP15 vs C. In diabetic NOD mice, a 7‐day treatment with either 1 or 3 mg kg−1 d−1 FP15 reversed increased tail‐flick latency (a sign of reduced pain sensitivity); the effect of the higher dose was significant as early as 3 days after beginning of the treatment. In conclusion, nitrosative stress plays a major role in DN in, at least, type 1 diabetes. This provides the rationale for development of agents counteracting peroxynitrite formation and promoting peroxynitrite decomposition, and their evaluation in DN.
dc.publisherKluwer Academic/Plenum Publishers
dc.publisherWiley Periodicals, Inc.
dc.subject.othertail-flick latency
dc.subject.otherstreptozotocin-diabetic rats
dc.subject.otherpoly(ADP-ribose) polymerase
dc.subject.otherNOD mice
dc.subject.othernerve
dc.subject.otherconduction deficit
dc.titleRole for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/154323/1/fsb2fj041913fje-sup-0001.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/154323/2/fsb2fj041913fje.pdf
dc.identifier.doi10.1096/fj.04-1913fje
dc.identifier.sourceThe FASEB Journal
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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