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Multiplex stress resistance in cells from long‐lived dwarf mice
dc.contributor.authorMurakami, Shin
dc.contributor.authorSalmon, Adam
dc.contributor.authorMiller, Richard A.
dc.date.accessioned2020-03-17T18:28:56Z
dc.date.available2020-03-17T18:28:56Z
dc.date.issued2003-08
dc.identifier.citationMurakami, Shin; Salmon, Adam; Miller, Richard A. (2003). "Multiplex stress resistance in cells from long‐lived dwarf mice." The FASEB Journal 17(11): 1565-1576.
dc.identifier.issn0892-6638
dc.identifier.issn1530-6860
dc.identifier.urihttps://hdl.handle.net/2027.42/154324
dc.description.abstractMutations that extend nematode longevity by interference with IGF‐I/insulin sensing pathways also lead to resistance to multiple forms of stress. Here, we report that skin‐derived fibroblasts from Snell dwarf mice, already known to show increased longevity and delayed aspects of aging, are resistant to multiple forms of cellular stress, including UV light, heat, paraquat, H2O2, and the toxic metal cadmium. The findings suggest that increases in cellular resistance to stress may mediate extended longevity in mammals.
dc.publisherWiley Periodicals, Inc.
dc.publisherAcademic Press
dc.subject.otherfibroblasts
dc.subject.otherdwarf mouse
dc.subject.othercellular stress resistance
dc.subject.otheraging
dc.titleMultiplex stress resistance in cells from long‐lived dwarf mice
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/154324/1/fsb2fj021092fje-sup-0001-S1.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/154324/2/fsb2fj021092fje.pdf
dc.identifier.doi10.1096/fj.02-1092fje
dc.identifier.sourceThe FASEB Journal
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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