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Adverse functions of IL‐17A in experimental sepsis
dc.contributor.authorFlierl, Michael A.
dc.contributor.authorRittirsch, Daniel
dc.contributor.authorGao, Hongwei
dc.contributor.authorHoesel, Laszlo M.
dc.contributor.authorNadeau, Brian A.
dc.contributor.authorDay, Danielle E.
dc.contributor.authorZetoune, Firas S.
dc.contributor.authorSarma, J. Vidya
dc.contributor.authorHuber-Lang, Markus S.
dc.contributor.authorFerrara, James L. M.
dc.contributor.authorWard, Peter A.
dc.date.accessioned2020-03-17T18:29:41Z
dc.date.available2020-03-17T18:29:41Z
dc.date.issued2008-07
dc.identifier.citationFlierl, Michael A.; Rittirsch, Daniel; Gao, Hongwei; Hoesel, Laszlo M.; Nadeau, Brian A.; Day, Danielle E.; Zetoune, Firas S.; Sarma, J. Vidya; Huber-Lang, Markus S.; Ferrara, James L. M.; Ward, Peter A. (2008). "Adverse functions of IL‐17A in experimental sepsis." The FASEB Journal 22(7): 2198-2205.
dc.identifier.issn0892-6638
dc.identifier.issn1530-6860
dc.identifier.urihttps://hdl.handle.net/2027.42/154352
dc.description.abstractIL‐17A is a proinflammatory cytokine produced by a variety of cells. In the current study, we examined the role of IL‐17A in sepsis induced in mice by cecal ligation and puncture (CLP). IL‐17A levels, which rose time‐dependently in plasma after CLP, were not affected in the absence of αβ T cells or neutrophils. In sharp contrast, γδ T cell‐knockout or γδ T cell‐depleted mice displayed baseline IL‐17A plasma levels after CLP. Neutralization of IL‐17A by two different antibodies improved sepsis (survival from ~10% to nearly 60%). Unexpectedly, antibody treatment was protective, even when administration of anti‐IL‐17A was delayed for up to 12 h after CLP. These protective effects of IL‐17A blockade were associated with substantially reduced levels of bacteremia together with significant reductions of systemic proinflammatory cytokines and chemokines in plasma. In vitro incubation of mouse peritoneal macrophages with lipopolysaccharide (LPS) in the copresence of IL‐17A substantially increased the production of TNF‐α, IL‐1β, and IL‐6 by these cells. These data suggest that, during experimental sepsis, γδ T cell‐derived IL‐17A promotes high levels of proinflammatory mediators and bacteremia, resulting in enhanced lethality. IL‐17A may be a potential therapeutic target in sepsis.—Flierl, M. A., Rittirsch, D., Gao, H., Hoesel, L. M., Nadeau, B. A., Day, D. E., Zetoune, F. S., Sarma, J. V., Huber‐Lang, M. S., Ferrara, J. L. M., Ward, P. A. Adverse functions of IL‐17A in experimental sepsis. FASEB J. 22, 2198–2205 (2008)
dc.publisherWiley Periodicals, Inc.
dc.subject.otherchemokines
dc.subject.othercolony-forming units
dc.subject.othersurvival
dc.subject.otherT cells
dc.subject.othery8
dc.subject.othercytokines
dc.titleAdverse functions of IL‐17A in experimental sepsis
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/154352/1/fsb2fj07105221.pdf
dc.identifier.doi10.1096/fj.07-105221
dc.identifier.sourceThe FASEB Journal
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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