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Protection of innate immunity by C5aR antagonist in septic mice
dc.contributor.authorHuber‐lang, Markus S.
dc.contributor.authorRiedeman, Niels C.
dc.contributor.authorSarma, J. Vidya
dc.contributor.authorYounkin, Ellen M.
dc.contributor.authorMcGuire, Stephanie R.
dc.contributor.authorLaudes, Ines J.
dc.contributor.authorLu, Kristina T.
dc.contributor.authorGuo, Ren‐feng
dc.contributor.authorNeff, Thomas A.
dc.contributor.authorPadgaonkar, Vaishalee A.
dc.contributor.authorLambris, John D.
dc.contributor.authorSpruce, L.
dc.contributor.authorMastellos, D.
dc.contributor.authorZetoune, Firas S.
dc.contributor.authorWard, Peter A.
dc.date.accessioned2020-03-17T18:29:59Z
dc.date.available2020-03-17T18:29:59Z
dc.date.issued2002-10
dc.identifier.citationHuber‐lang, Markus S. ; Riedeman, Niels C.; Sarma, J. Vidya; Younkin, Ellen M.; McGuire, Stephanie R.; Laudes, Ines J.; Lu, Kristina T.; Guo, Ren‐feng ; Neff, Thomas A.; Padgaonkar, Vaishalee A.; Lambris, John D.; Spruce, L.; Mastellos, D.; Zetoune, Firas S.; Ward, Peter A. (2002). "Protection of innate immunity by C5aR antagonist in septic mice." The FASEB Journal 16(12): 1567-1574.
dc.identifier.issn0892-6638
dc.identifier.issn1530-6860
dc.identifier.urihttps://hdl.handle.net/2027.42/154360
dc.description.abstractInnate immune functions are known to be compromised during sepsis, often with lethal consequences. There is also evidence in rats that sepsis is associated with excessive complement activation and generation of the potent anaphylatoxin C5a. In the presence of a cyclic peptide antagonist (C5aRa) to the C5a receptor (C5aR), the binding of murine 125Iâ C5a to murine neutrophils was reduced, the in vitro chemotactic responses of mouse neutrophils to mouse C5a were markedly diminished, the acquired defect in hydrogen peroxide (H2O2) production of C5aâ exposed neutrophils was reversed, and the lung permeability index (extravascular leakage of albumin) in mice after intrapulmonary deposition of IgG immune complexes was markedly diminished. Mice that developed sepsis after cecal ligation/puncture (CLP) and were treated with C5aRa had greatly improved survival rates. These data suggest that C5aRa interferes with neutrophil responses to C5a, preventing C5aâ induced compromise of innate immunity during sepsis, with greatly improved survival rates after CLP.â Huberâ Lang, M. S., Riedeman, N. C., Sarma, J. V., Younkin, E. M., McGuire, S. R., Laudes, I. J., Lu, K. T., Guo, R.â F., Neff, T. A., Padgaonkar, V. A., Lambris, J. D., Spruce, L., Mastellos, D., Zetoune, F. S., Ward, P. A. Protection of innate immunity by C5aR antagonist in septic mice. FASEB J. 16, 1567â 1574 (2002)
dc.publisherWiley Periodicals, Inc.
dc.subject.otheroxidative burst
dc.subject.othersepsis
dc.subject.otherneutrophil
dc.subject.otherblood clearance
dc.titleProtection of innate immunity by C5aR antagonist in septic mice
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/154360/1/fsb2fj020209com.pdf
dc.identifier.doi10.1096/fj.02-0209com
dc.identifier.sourceThe FASEB Journal
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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