View Item 

Show simple item record

Evidence for a functional role of the second C5a receptor C5L2
dc.contributor.authorGao, Hongwei
dc.contributor.authorNeff, Thomas A.
dc.contributor.authorGuo, Ren‐feng
dc.contributor.authorSpeyer, Cecilia L.
dc.contributor.authorSarma, J. Vidya
dc.contributor.authorTomlins, Scott
dc.contributor.authorMan, Yunfang
dc.contributor.authorRiedemann, Niels C.
dc.contributor.authorHoesel, L. Marco
dc.contributor.authorYounkin, Ellen
dc.contributor.authorZetoune, Firas S.
dc.contributor.authorWard, Peter A.
dc.date.accessioned2020-03-17T18:31:34Z
dc.date.available2020-03-17T18:31:34Z
dc.date.issued2005-06
dc.identifier.citationGao, Hongwei; Neff, Thomas A.; Guo, Ren‐feng ; Speyer, Cecilia L.; Sarma, J. Vidya; Tomlins, Scott; Man, Yunfang; Riedemann, Niels C.; Hoesel, L. Marco; Younkin, Ellen; Zetoune, Firas S.; Ward, Peter A. (2005). "Evidence for a functional role of the second C5a receptor C5L2." The FASEB Journal 19(8): 1003-1005.
dc.identifier.issn0892-6638
dc.identifier.issn1530-6860
dc.identifier.urihttps://hdl.handle.net/2027.42/154410
dc.description.abstractDuring experimental sepsis in rodents after cecal ligation and puncture (CLP), excessive C5a is generated, leading to interactions with C5aR, loss of innate immune functions of neutrophils, and lethality. In the current study, we have analyzed the expression of the second C5a receptor C5L2, the putative â defaultâ or nonsignaling receptor for C5a. Rat C5L2 was cloned, and antibody was developed to C5L2 protein. After CLP, blood neutrophils showed a reduction in C5aR followed by its restoration, while C5L2 levels gradually increased, accompanied by the appearance of mRNA for C5L2. mRNA for C5L2 increased in lung and liver during CLP. Substantially increased C5L2 protein (defined by binding of 125Iâ antiâ C5L2 IgG) occurred in lung, liver, heart, and kidney after CLP. With the use of serum ILâ 6 as a marker for sepsis, infusion of antiâ C5aR dramatically reduced serum ILâ 6 levels, while antiâ C5L2 caused a nearly fourfold increase in ILâ 6 when compared with CLP controls treated with normal IgG. When normal blood neutrophils were stimulated in vitro with LPS and C5a, the antibodies had similar effects on release of ILâ 6. These data provide the first evidence for a role for C5L2 in balancing the biological responses to C5a.
dc.publisherFederation of American Societies for Experimental Biology
dc.publisherWiley Periodicals, Inc.
dc.subject.otherILâ 6
dc.subject.othercecal ligation and puncture
dc.titleEvidence for a functional role of the second C5a receptor C5L2
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/154410/1/fsb2fj043424fje.pdf
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/154410/2/fsb2fj043424fje-sup-0040.pdf
dc.identifier.doi10.1096/fj.04-3424fje
dc.identifier.sourceThe FASEB Journal
dc.identifier.citedreferenceHuberâ Lang, M. S., Sarma, J. V., McGuire, S. R., Lu, K. T., Guo, R. F., Padgaonkar, V. A., Younkin, E. M., Laudes, I. J., Riedemann, N. C., Younger, J. G., et al. ( 2001 ) Protective effects of antiâ C5a peptide antibodies in experimental sepsis. FASEB J. 15, 568 â 570
dc.identifier.citedreferenceShin, H. S., Snyderman, R., Friedman, E., Mellors, A., and Mayer, M. M. ( 1968 ) Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement. Science 162, 361 â 363
dc.identifier.citedreferenceHuberâ Lang, M., Sarma, V. J., Lu, K. T., McGuire, S. R., Padgaonkar, V. A., Guo, R. F., Younkin, E. M., Kunkel, R. G., Ding, J., Erickson, R., et al. ( 2001 ) Role of C5a in multiorgan failure during sepsis. J. Immunol. 166, 1193 â 1199
dc.identifier.citedreferenceGuo, R. F., Riedemann, N. C., Bernacki, K. D., Sarma, V. J., Laudes, I. J., Reuben, J. S., Younkin, E. M., Neff, T. A., Paulauskis, J. D., Zetoune, F. S., et al. ( 2003 ) Neutrophil C5a receptor and the outcome in a rat model of sepsis. FASEB J. 17, 1889 â 1891
dc.identifier.citedreferenceCzermak, B. J., Sarma, V., Pierson, C. L., Warner, R. L., Huberâ Lang, M., Bless, N. M., Schmal, H., Friedl, H. P., and Ward, P. A. ( 1999 ) Protective effects of C5a blockade in sepsis. Nat. Med. 5, 788 â 792
dc.identifier.citedreferenceHuberâ Lang, M. S., Younkin, E. M., Sarma, J. V., McGuire, S. R., Lu, K. T., Guo, R. F., Padgaonkar, V. A., Curnutte, J. T., Erickson, R., and Ward, P. A. ( 2002 ) Complementâ induced impairment of innate immunity during sepsis. J. Immunol. 169, 3223 â 3231
dc.identifier.citedreferenceStevens, J. H., O’Hanley, P., Shapiro, J. M., Mihm, F. G., Satoh, P. S., Collins, J. A., and Raffin, T. A. ( 1986 ) Effects of antiâ C5a antibodies on the adult respiratory distress syndrome in septic primates. J. Clin. Invest. 77, 1812 â 1816
dc.identifier.citedreferenceHangen, D. H., Stevens, J. H., Satoh, P. S., Hall, E. W., O’Hanley, P. T., and Raffin, T. A. ( 1989 ) Complement levels in septic primates treated with antiâ C5a antibodies. J. Surg. Res. 46, 195 â 199
dc.identifier.citedreferenceGerard, N. P., Hodges, M. K., Drazen, J. M., Weller, P. F., and Gerard, C. ( 1989 ) Characterization of a receptor for C5a anaphylatoxin on human eosinophils. J. Biol. Chem. 264, 1760 â 1766
dc.identifier.citedreferenceGerard, N. P., and Gerard, C. ( 1991 ) The chemotactic receptor for human C5a anaphylatoxin. Nature 349, 614 â 617
dc.identifier.citedreferenceZwirner, J., Fayyazi, A., and Gotze, O. ( 1999 ) Expression of the anaphylatoxin C5a receptor in nonâ myeloid cells. Mol. Immunol. 36, 877 â 884
dc.identifier.citedreferenceHaviland, D. L., McCoy, R. L., Whitehead, W. T., Akama, H., Molmenti, E. P., Brown, A., Haviland, J. C., Parks, W. C., Perlmutter, D. H., and Wetsel, R. A. ( 1995 ) Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung. J. Immunol. 154, 1861 â 1869
dc.identifier.citedreferenceFloreani, A. A., Heires, A. J., Welniak, L. A., Millerâ Lindholm, A., Clarkâ Pierce, L., Rennard, S. I., Morgan, E. L., and Sanderson, S. D. ( 1998 ) Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5aâ mediated release of ILâ 8 upon exposure to cigarette smoke. J. Immunol. 160, 5073 â 5081
dc.identifier.citedreferenceSchieferdecker, H. L., Schlaf, G., Koleva, M., Gotze, O., and Jungermann, K. ( 2000 ) Induction of functional anaphylatoxin C5a receptors on hepatocytes by in vivo treatment of rats with ILâ 6. J. Immunol. 164, 5453 â 5458
dc.identifier.citedreferenceWetsel, R. A. ( 1995 ) Expression of the complement C5a anaphylatoxin receptor (C5aR) on nonâ myeloid cells. Immunol. Lett. 44, 183 â 187
dc.identifier.citedreferenceGasque, P., Singhrao, S. K., Neal, J. W., Gotze, O., and Morgan, B. P. ( 1997 ) Expression of the receptor for complement C5a (CD88) is upâ regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system. Am. J. Pathol. 150, 31 â 41
dc.identifier.citedreferenceChenoweth, D. E., and Hugli, T. E. ( 1978 ) Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes. Pro. Natl. Acad. Sci. USA. 75, 3943 â 3947
dc.identifier.citedreferenceNataf, S., Davoust, N., Ames, R. S., and Barnum, S. R. ( 1999 ) Human T cells express the C5a receptor and are chemoattracted to C5a. J. Immunol. 162, 4018 â 4023
dc.identifier.citedreferenceRiedemann, N. C., Guo, R. F., Neff, T. A., Laudes, I. J., Keller, K. A., Sarma, V. J., Markiewski, M. M., Mastellos, D., Strey, C. W., Pierson, C. L., et al. ( 2002 ) Increased C5a receptor expression in sepsis. J. Clin. Invest. 110, 101 â 108
dc.identifier.citedreferenceOkinaga, S., Slattery, D., Humbles, A., Zsengeller, Z., Morteau, O., Kinrade, M. B., Brodbeck, R. M., Krause, J. E., Choe, H. R., Gerard, N. P., et al. ( 2003 ) C5L2, a nonsignaling C5A binding protein. Biochemistry 42, 9406 â 9415
dc.identifier.citedreferenceKalant, D., Cain, S. A., Maslowska, M., Sniderman, A. D., Cianflone, K., and Monk, P. N. ( 2003 ) The chemoattractant receptorâ like protein C5L2 binds the C3a desâ Arg77/acylationâ stimulating protein. J. Biol. Chem. 278, 11123 â 11129
dc.identifier.citedreferenceCain, S. A., and Monk, P. N. ( 2002 ) The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a desâ Arg(74). J. Biol. Chem. 277, 7165 â 7169
dc.identifier.citedreferenceOhno, M., Hirata, T., Enomoto, M., Araki, T., Ishimaru, H., and Takahashi, T. A. ( 2000 ) A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells. Mol. Immunol. 37, 407 â 412
dc.identifier.citedreferenceFarzan, M., Schnitzler, C. E., Vasilieva, N., Leung, D., Kuhn, J., Gerard, C., Gerard, N. P., and Choe, H. ( 2001 ) Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor. J. Exp. Med. 193, 1059 â 1066
dc.identifier.citedreferenceMorgan, E. L., Ember, J. A., Sanderson, S. D., Scholz, W., Buchner, R., Ye, R. D., and Hugli, T. E. ( 1993 ) Antiâ C5a receptor antibodies. Characterization of neutralizing antibodies specific for a peptide, C5aRâ (9â 29), derived from the predicted aminoâ terminal sequence of the human C5a receptor. J. Immunol. 151, 377 â 388
dc.identifier.citedreferenceRiedemann, N. C., Guo, R. F., Hollmann, T. J., Gao, H., Neff, T. A., Reuben, J. S., Speyer, C. L., Sarma, J. V., Wetsel, R. A., et al. ( 2004 ) Regulatory role of C5a in LPSâ induced ILâ 6 production by neutrophils during sepsis. FASEB J. 18, 370 â 372.
dc.identifier.citedreferenceWard, P. A., Riedemann, N. C., Guo, R. F., Huberâ Lang, M., Sarma, J. V. and Zetoune, F. S. ( 2003 ) Antiâ complement strategies in experimental sepsis. Scand. J. Infect. Dis. 35, 601 â 603.
dc.identifier.citedreferenceNaik, N., Giannini, E., Brouchon, L., and Boulay, F. ( 1997 ) Internalization and recycling of the C5a anaphylatoxin receptor: evidence that the agonistâ mediated internalization is modulated by phosphorylation of the Câ terminal domain. J. Cell Sci. 110, 2381 â 2390.
dc.identifier.citedreferenceGiannini, E., and Boulay, F. ( 1995 ) Phosphorylation, dephosphorylation, and recycling of the C5a receptor in differentiated HL60 cells. J. Immunol. 154, 4055 â 4064.
dc.identifier.citedreferenceVan Epps, D. E., Simpson, S., Bender, J. G., and Chenoweth, J. E. ( 19900. Regulation of C5a and formyl peptide receptor expression on human polymorphonuclear leukocytes. J. Immunol. 144, 1062 â 1068.
dc.identifier.citedreferenceWard, P. A. ( 2004 ) The dark side of C5a in sepsis. Nat. Rev. Immunol. 4, 133 â 142
dc.identifier.citedreferenceRiedemann, N. C., Guo, R. F., and Ward, P. A. ( 2003 ) Novel strategies for the treatment of sepsis. Nat. Med. 9, 517 â 524
dc.identifier.citedreferenceCochrane, C. G., and Mullerâ Eberhard, H. J. ( 1968 ) The derivation of two distinct anaphylatoxin activities from the third and fifth components of human complement. J. Exp. Med. 127, 371 â 386
dc.identifier.citedreferenceGoldstein, I. M., and Weissmann, G. ( 1974 ) Generation of C5â derived lysosomal enzymeâ releasing activity (C5a) by lysates of leukocyte lysosomes. J. Immunol. 113, 1583 â 1588
dc.identifier.citedreferenceSacks, T., Moldow, C. F., Craddock, P. R., Bowers, T. K., and Jacob, H. S. ( 1978 ) Oxygen radicals mediate endothelial cell damage by complementâ stimulated granulocytes. An in vitro model of immune vascular damage. J. Clin. Invest. 61, 1161 â 1167
dc.identifier.citedreferenceSchumacher, W. A., Fantone, J. C., Kunkel, S. E., Webb, R. C., and Lucchesi, B. R. ( 1991 ) The anaphylatoxins C3a and C5a are vasodilators in the canine coronary vasculature in vitro and in vivo. Agents Actions 34, 345 â 349
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
fsb2fj043424fje.pdf
Size:
1.313MB
Format:
PDF
View/Open
Name:
fsb2fj043424fje-sup-0040.pdf
Size:
191.9KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe its collections in a way that respects the people and communities who create, use, and are represented in them. We encourage you to Contact Us anonymously if you encounter harmful or problematic language in catalog records or finding aids. More information about our policies and practices is available at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.