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Preservation of circadian rhythms by the protein folding chaperone, BiP
dc.contributor.authorPickard, Adam
dc.contributor.authorChang, Joan
dc.contributor.authorAlachkar, Nissrin
dc.contributor.authorCalverley, Ben
dc.contributor.authorGarva, Richa
dc.contributor.authorArvan, Peter
dc.contributor.authorMeng, Qing-Jun
dc.contributor.authorKadler, Karl E.
dc.date.accessioned2020-03-17T18:31:58Z
dc.date.availableWITHHELD_4_MONTHS
dc.date.available2020-03-17T18:31:58Z
dc.date.issued2019-06
dc.identifier.citationPickard, Adam; Chang, Joan; Alachkar, Nissrin; Calverley, Ben; Garva, Richa; Arvan, Peter; Meng, Qing-Jun; Kadler, Karl E. (2019). "Preservation of circadian rhythms by the protein folding chaperone, BiP." The FASEB Journal 33(6): 7479-7489.
dc.identifier.issn0892-6638
dc.identifier.issn1530-6860
dc.identifier.urihttps://hdl.handle.net/2027.42/154424
dc.description.abstractDysregulation of collagen synthesis is associated with disease progression in cancer and fibrosis. Collagen synthesis is coordinated with the circadian clock, which in cancer cells is, curiously, deregulated by endoplasmic reticulum (ER) stress. We hypothesized interplay between circadian rhythm, collagen synthesis, and ER stress in normal cells. Here we show that fibroblasts with ER stress lack circadian rhythms in gene expression upon clock‐synchronizing time cues. Overexpression of binding immunoglobulin protein (BiP) or treatment with chemical chaperones strengthens the oscillation amplitude of circadian rhythms. The significance of these findings was explored in tendon, where we showed that BiP expression is ramped preemptively prior to a surge in collagen synthesis at night, thereby preventing protein misfolding and ER stress. In turn, this forestalls activation of the unfolded protein response in order for circadian rhythms to be maintained. Thus, targeting ER stress could be used to modulate circadian rhythm and restore collagen homeostasis in disease.—Pickard, A., Chang, J., Alachkar, N., Calverley, B., Garva, R., Arvan, P., Meng, Q.‐J., Kadler, K. E. Preservation of circadian rhythms by the protein folding chaperone, BiP. FASEB J. 33, 000–000 (2019). www.fasebj.org
dc.publisherFederation of American Societies for Experimental Biology
dc.publisherWiley Periodicals, Inc.
dc.subject.other4PBA
dc.subject.otherER stress
dc.subject.otherPer2::luc
dc.subject.otherUDCA
dc.subject.othercollagen
dc.titlePreservation of circadian rhythms by the protein folding chaperone, BiP
dc.typeArticle
dc.rights.robotsIndexNoFollow
dc.subject.hlbsecondlevelBiology
dc.subject.hlbtoplevelScience
dc.description.peerreviewedPeer Reviewed
dc.description.bitstreamurlhttps://deepblue.lib.umich.edu/bitstream/2027.42/154424/1/fsb2fj201802366rr.pdf
dc.identifier.doi10.1096/fj.201802366RR
dc.identifier.sourceThe FASEB Journal
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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